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Cationic emulsions improves the delivery of oligonucleotides to leukemic P388/ADR cells in ascite.
J Control Release
May 2003
Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, UMR 8612, Université Paris XI, Centre d'Etudes Pharmaceutiques 5, Rue J B Clément 92296, Châtenay-Malabry, France.
The aim of this study was to investigate the in vivo ability of O/W cationic emulsions to deliver oligonucleotides (ON) in leukemic P388/ADR cells in ascite, after intraperitoneal (IP) administration in mice. Cationic emulsions were prepared by microfluidization as previously described by Teixeira et al. [Pharm.
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