96 results match your criteria: "Centre d'Anthropobiologie et de Génomique de Toulouse[Affiliation]"

Manual Hair Removal for Intraoral Flaps: a Simple Practice for Professional Education and Patient Cancer Care.

J Cancer Educ

October 2024

Département d'Odontologie, Université Paul Sabatier, Service d'Odontologie, Centre Hospitalier Universitaire, Laboratoire Centre d'Anthropobiologie Et de Génomique de Toulouse, 3 Chemin Des Maraîchers, 31400, Toulouse, France.

After resection of malignant tumors of the head and neck, reconstructions are commonly performed using surgical free flaps. In non-irradiated patients, hair may continue to grow at the reconstruction site after surgery, causing undesirable effects such as difficult to maintain oral hygiene, food and saliva accumulation, halitosis, dysphagia, moral distress, and impact on intimacy and sexuality. Until a standardized laser therapy protocol is available, manual depilation is an option that should not be underestimated to improve the patient's quality of life and available to every oral healthcare team.

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Article Synopsis
  • The horse family (equids) has a rich fossil record showing significant evolutionary changes over the last 55 million years, with a wealth of ancient genomes sequenced to understand their domestication history.
  • This study generated genome-wide data from 25 ancient equid specimens spanning 44,000 years in regions like Anatolia and Mongolia, revealing the presence of extinct species and new insights into their survival.
  • The research also identified genetic differences among Asian wild asses and a common genetic signature in wild asses across continents, raising questions about the role of specific genetic changes in the extinction of certain equid species.
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Long genetic and social isolation in Neanderthals before their extinction.

Cell Genom

September 2024

Lundbeck Foundation GeoGenetics Center, University of Copenhagen, 1350K Copenhagen, Denmark. Electronic address:

Article Synopsis
  • Neanderthal genomes from various Eurasian sites reveal that late European Neanderthals likely formed a single, interconnected population with little internal structure.
  • The discovery of "Thorin," a late Neanderthal from Grotte Mandrin in France, includes his unique dental fossils and provides insights into their culture around 50,000 to 42,000 years ago.
  • Thorin's genome indicates he was genetically isolated for about 50,000 years from other late Neanderthals, suggesting distinct lineage differences that could help explain their eventual disappearance.
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Origin and evolution of the bread wheat D genome.

Nature

September 2024

Plant Science Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.

Bread wheat (Triticum aestivum) is a globally dominant crop and major source of calories and proteins for the human diet. Compared with its wild ancestors, modern bread wheat shows lower genetic diversity, caused by polyploidisation, domestication and breeding bottlenecks. Wild wheat relatives represent genetic reservoirs, and harbour diversity and beneficial alleles that have not been incorporated into bread wheat.

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Background: Centromere function is highly conserved across eukaryotes, but the underlying centromeric DNA sequences vary dramatically between species. Centromeres often contain a high proportion of repetitive DNA, such as tandem repeats and/or transposable elements (TEs). Einkorn wheat centromeres lack tandem repeat arrays and are instead composed mostly of the two long terminal repeat (LTR) retrotransposon families RLG_Cereba and RLG_Quinta which specifically insert in centromeres.

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Reconstructing generation intervals over time.

Nat Rev Genet

November 2024

Centre d'Anthropobiologie et de Génomique de Toulouse, CNRS UMR 5288, Université Paul Sabatier, Faculté de Médecine Purpan, Toulouse, France.

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Cases of battery ingestion are well documented in the scientific literature, especially concerning button cell battery ingestion in children. In this instance, the authors present an atypical case of a young man who voluntarily ingested a cylindrical alkaline battery containing manganese. The patient died approximately a week later, despite not exhibiting any specific symptoms.

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  • * Analysis of blood pressure and plasma EDN3 levels in Coldblooded trotters and Standardbreds revealed that horses with a sub-elite haplotype had significantly higher blood pressure during exercise compared to those with an elite haplotype.
  • * The findings shed light on the genetic factors influencing athletic performance and vascular traits, suggesting that certain elite haplotypes were present in pre-domestication horses but became more common through selective breeding in modern horses.
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Widespread horse-based mobility arose around 2200 BCE in Eurasia.

Nature

July 2024

Centre d'Anthropobiologie et de Génomique de Toulouse, CNRS UMR 5288, Université Paul Sabatier, Faculté de Médecine Purpan, Toulouse, France.

Article Synopsis
  • - Horses transformed human mobility, but the timeline of their domestication and integration as transport is debated, with new genetic data being used to clarify this history.
  • - Analysis of 475 ancient horse genomes indicates that modern domestic horses were shaped by human intervention around 2200 BCE, after a domestication bottleneck began around 2700 BCE, leading to a significant expansion across Eurasia.
  • - Evidence also suggests that there was early horse husbandry in central Asia at Botai around 3500 BCE, prior to the establishment of contemporary horse bloodlines, challenging the notion of large herds being linked to migrations around 3000 BCE.
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The juvenile mandible is important in the investigation of ontogenetic and evolutionary changes among early hominins. We revisit the mandibular symphysis in juvenile specimens of Australopithecus africanus and Paranthropus robustus with two main contributions. First, we employ, for the first time, methods of computational anatomy to model complex symphyseal shape differences.

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  • The study analyzes 317 ancient genomes from Mesolithic and Neolithic periods across northern and western Eurasia to understand human migration impacts during the Holocene.* -
  • Findings show a significant genetic divide between eastern and western populations, with the west experiencing major gene replacement due to the introduction of farming, while the east maintained its hunter-gatherer ancestry longer.* -
  • The Yamnaya culture, which emerged around 5,000 BP, played a crucial role in spreading ancestry across western Eurasia, leading to significant genetic changes in European populations.*
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This study aimed to evaluate the feasibility of preclinical training, specifically in root canal preparation, using a virtual educational system equipped with an operating microscope. Ten postgraduate general dentistry trainees and practitioners undergoing postgraduate training in endodontics participated. The telesimulation course included three steps: theory, demonstration of practical work by the teacher and lastly practical training by the participants.

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Ancient chicken remains reveal the origins of virulence in Marek's disease virus.

Science

December 2023

Palaeogenomics Group, Institute of Palaeoanatomy, Domestication Research and the History of Veterinary Medicine, Ludwig-Maximilians-Universitat, Munich, Germany.

The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek's disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually.

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Zooarchaeological analyses of the skeletal remains of 52 animals unearthed in the courtyard of an Iron Age Tartessian building known as Casas del Turuñuelo (Badajoz, Spain) shed light on a massive sacrifice forming part of a series of rituals linked to the site's last period of activity and final abandonment. The rites took place towards the end of the 5th century BCE when both the building (intentionally destroyed) and the sacrificed animals were intentionally buried under a tumulus 90 m in diameter and 6 m high. The main objective of the zooarchaeological and microstratigraphic analyses was to determine the phasing of the sacrificial depositions.

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Introduction: Treating anterior restorations is a real challenge for a dentist and conventional protocols are not always applicable. The aim of this study is to determine different therapeutic to conducting anterior restorations in disabled people.

Case Report: We begin by presenting the case of a 23-year-old, handicapped man, who was brought in consultation to compensate for the loss of the left upper central incisor (#21).

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Imputed genomes of historical horses provide insights into modern breeding.

iScience

July 2023

Centre d'Anthropobiologie et de Génomique de Toulouse (CAGT), CNRS UMR 5288, Université Paul Sabatier, 37 Allées Jules Guesde, Bâtiment A, 31000 Toulouse, France.

Article Synopsis
  • Scientists studied the DNA of 430 horses from 73 breeds to learn about changes in horse genes over time.
  • They looked at special horses, like Clydesdales and Thoroughbreds, to see how modern horses are related to famous historical horses.
  • The research showed that some modern horses are more closely related to ancient horses, but there has also been a lot of inbreeding, which is when closely related horses breed together.
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The Y chromosome carries information about the demography of paternal lineages, and thus, can prove invaluable for retracing both the evolutionary trajectory of wild animals and the breeding history of domesticates. In horses, the Y chromosome shows a limited, but highly informative, sequence diversity, supporting the increasing breeding influence of Oriental lineages during the last 1500 years. Here, we augment the primary horse Y-phylogeny, which is currently mainly based on modern horse breeds of economic interest, with haplotypes (HT) segregating in remote horse populations around the world.

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Improving the extraction of ancient genomes from the dental pulp.

iScience

May 2023

Centre d'Anthropobiologie et de Génomique de Toulouse (CAGT), CNRS UMR5288, Université Paul Sabatier, 37 allées Jules Guesde, 31000 Toulouse, France.

Article Synopsis
  • * Researchers discovered that most ancient DNA is released within 60 minutes at 37°C, suggesting a quick pre-digestion process is beneficial.
  • * This method, combined with DNA capture techniques, enabled the analysis of 12 ancient bacteria from France related to pandemics in the 17th and 18th centuries.
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Comparison of muscle metabolomics between two Chinese horse breeds.

Front Vet Sci

May 2023

Laboratory of Animal (Poultry) Genetics Breeding and Reproduction, Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing, China.

With their enormous muscle mass and athletic ability, horses are well-positioned as model organisms for understanding muscle metabolism. There are two different types of horse breeds-Guanzhong (GZ) horses, an athletic breed with a larger body height (~148.7 cm), and the Ningqiang pony (NQ) horses, a lower height breed generally used for ornamental purposes-both inhabited in the same region of China with obvious differences in muscle content.

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A review of the pangenome: how it affects our understanding of genomic variation, selection and breeding in domestic animals?

J Anim Sci Biotechnol

May 2023

Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences (CAAS), Beijing, 100193, China.

Article Synopsis
  • A single reference genome cannot capture the genetic diversity of a species, particularly in domesticated animals which may have unique, population-specific sequences missing from current models.
  • The concept of a pangenome includes a complete set of DNA sequences from a species, highlighting both shared (core) and individual-specific (variable) sequences that influence traits and adaptability.
  • Advances in sequencing technologies and methods are set to enhance pangenome research, particularly in understanding structural variations and their connections to important traits in animals, offering future directions for evolution and breeding studies.
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Article Synopsis
  • Scientists study old animal bones to learn how people took care of animals a long time ago, but it’s hard because the bones are often broken and there aren’t clear signs of age.
  • *Using a special method called DNA methylation clocks, researchers can figure out how old some ancient animals were when they died.
  • *They also looked at DNA to understand if horses were castrated in the past, which helps reveal more about how people managed animals and their lives a long time ago.
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