436 results match your criteria: "Centre Régional de Dépistage Néonatal Hauts-de-France[Affiliation]"

The art and science of translucent color organic solar cells.

Nat Commun

January 2025

Department of Physics, Research Centre of Excellence for Organic Electronics and Institute of Advanced Materials, Hong Kong Baptist University, Hong Kong, China.

The artistic and scientific perspectives of the translucent color organic solar cells (OSCs), made with the emerging narrowband nonfullerene acceptors are explored. The translucent color OSCs, comprising a Fabry-Pérot microcavity optical coupling layer, have a power conversion efficiency of >15% and a maximum transparency of >20% for the three primary colors. The performance-color relationship of the translucent color OSCs is analyzed using a combination of high-throughput optical computing and experimental optimization, allowing light with desired color to pass through, while absorbing enough light to generate electricity.

View Article and Find Full Text PDF

Background: Aarskog-Scott syndrome (AAS) is a rare condition with multiple congenital anomalies, caused by hemizygote variants in the gene. Its description was based mostly on old case reports, in whom a molecular diagnosis was not always available, or on small series. The aim of this study was to better delineate the phenotype and the natural history of AAS and to provide clues for the diagnosis and the management of the patients.

View Article and Find Full Text PDF

Correction to: SERS characterization of aggregated and isolated bacteria deposited on silver-based substrates.

Anal Bioanal Chem

January 2025

Laboratoire de Physique de la Matière Condensée, CNRS, Ecole Polytechnique, Institut Polytechnique de Paris, 91120, Palaiseau, France.

View Article and Find Full Text PDF

Background: Cleft lip and/or palate is the most common congenital orofacial deformity, affecting 1/800 births. A thorough review of the literature has shown that children with cleft have poorer oral hygiene and dental health than other children, with higher levels of caries in both temporary and permanent teeth and poorer periodontal health. Cleft patients are treated by a multidisciplinary team that aims to provide comprehensive care from pre- or post-natal diagnosis to early adulthood and the end of growth.

View Article and Find Full Text PDF

Background: Intensive care units (ICUs) handle the most critical patients with a high risk of mortality. Due to those conditions, close monitoring is necessary and therefore, a large volume of data is collected. Collaborative ventures have enabled the emergence of large open access databases, leading to numerous publications in the field.

View Article and Find Full Text PDF

Objective: The objective of this study was to analyse the association between body composition and changes in health-related quality of life (HRQoL) of patients followed for hip and knee osteoarthritis (OA).

Methods: Longitudinal data from the Knee and Hip OsteoArthritis Long-term Assessments (KHOALA) cohort, a multicentre cohort of 878 patients with symptomatic knee and/or hip OA, were used. The main outcome criteria were changes in patient-reported outcomes measures, the Study Short Form-36 (physical functioning, pain, mental health and vitality) and the OsteoArthritis Knee and Hip Quality Of Life (OAKHQOL)(physical activity, pain and mental health).

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to standardize qPCR procedures for diagnosing Mucorales by examining factors that influence DNA extraction and PCR amplification efficiency.
  • Two panels of samples were distributed to 26 laboratories, and results showed that using larger serum volumes for DNA extraction and larger input volumes for PCR significantly improved detection sensitivity.
  • Findings highlight the importance of optimizing laboratory techniques to enhance diagnosis of Mucormycosis, a serious fungal infection, which is critical for timely treatment in vulnerable patients.
View Article and Find Full Text PDF

MRI-directed Micro-US-guided Transperineal Focal Laser Ablation for Localized Prostate Cancer: A 1-year Follow-up Study.

Radiology

December 2024

From the Departments of Radiology (F.C., A.L.) and Urology (M.G.), Clinique de l'Alma, 166 Rue de l'Université, 75007 Paris, France; Department of Urology, Amsterdam UMC location Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands (K.d.B., L.v.R.); and Department of Pathology, i-Path Institut de Pathologie des Hauts-de-France, Amiens, France (P.C.).

Background MRI-guided focal laser ablation (FLA) is a promising treatment in localized prostate cancer (PCa). MRI-guided micro-US FLA shows potential for outpatient use, but its clinical application remains unexplored. Purpose To evaluate the safety, feasibility, and 12-month functional and oncologic outcomes of MRI-guided micro-US transperineal FLA in localized PCa and to assess the accuracy of micro-US in showing lesions depicted at MRI with Prostate Imaging Reporting and Data System (PI-RADS) score of 3 or higher.

View Article and Find Full Text PDF

Background And Aims: Systemic sclerosis (SSc) is an autoimmune connective disease characterised by excessive extracellular matrix deposition and widespread skin and internal organ fibrosis including various cardiac manifestations. Heart involvement is one of the leading causes of death among patients with SSc. In this study, we aimed to assess the effect of various vasodilator treatments.

View Article and Find Full Text PDF

Spintronic terahertz emitters with integrated metallic terahertz cavities.

Nanophotonics

April 2024

Laboratoire de Physique de l'Ecole Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité, F-75005, Paris, France.

Spintronic terahertz emitters (STEs), based on optical excitation of nanometer thick ferromagnetic/heavy metal (FM/HM) heterojunctions, have become important sources for the generation of terahertz (THz) pulses. However, the efficiency of the optical-to-THz conversion remains limited. Although optical techniques have been developed to enhance the optical absorption, no investigations have studied the application of THz cavities.

View Article and Find Full Text PDF

Non-medical nitrous oxide misuse: From identifying a signal to unprecedented addictovigilance network communication.

Therapie

October 2024

INSERM, methodS in Patient-centered outcomes & HEalth ResEarch, Nantes université, CHU Nantes, 44000 Nantes, France. Electronic address:

Addictovigilance is a French health monitoring system, composed of 13 centres distributed across the national territory, that aims to monitor cases of abuse, misuse, or use disorders related to psychoactive substances. Fulfilling these missions requires a regional network that ensures efficient information flow, dissemination to health authorities, and subsequent downward communication to prevent risks. This was illustrated through the example of nitrous oxide misuse.

View Article and Find Full Text PDF

Objective: The objective of the present study was to develop a method for sampling and detecting an adenovirus-derived gene therapy (GT) vector on isolator worksurfaces.

Methods: We used a quantitative PCR (q-PCR) to detect the viral genome in standard dilutions of pure GT product and extracts of sampled surfaces. We compared three devices for surface sampling (a cotton compress, a cotton swab and a polyester flocked swab) and performed positive control, negative control and induced contamination tests for each.

View Article and Find Full Text PDF

Expression of concern for 'An 'on-demand' photothermal antibiotic release cryogel patch: evaluation of efficacy on an model for skin wound infection' by Léa Rosselle, , , 2020, , 5911-5919, https://doi.org/10.1039/D0BM01535K.

View Article and Find Full Text PDF

Association between acute exacerbation of chronic obstructive pulmonary disease and short-term exposure to ambient air pollutants in France.

Environ Health

November 2024

Department of Respiratory Disease and Critical Care Unit, University Hospital Center, Amiens-Picardie. 1, Rue du Professeur Christian Cabrol, Amiens-Cedex, 80054, France.

Article Synopsis
  • Ambient air pollution is a significant risk factor for chronic obstructive pulmonary disease (COPD), which is a leading cause of death globally, and this study investigated the link between daily air pollutant levels and emergency room visits for acute COPD exacerbations.
  • The research was conducted in Amiens, France, in 2017, analyzing 240 emergency room visits among 168 COPD patients and focusing specifically on pollutants like nitrogen dioxide, ozone, and particulate matter, while accounting for other factors like temperature and pollen allergies.
  • The results showed a notable correlation between daily emergency visits and particulate matter concentrations, while long-term exposure to air pollutants did not show a consistent link to more frequent COPD exacerbations.
View Article and Find Full Text PDF

Introduction: Transition of care from hospital to primary care has been recognised globally as a high-risk scenario for older patients' safety by the WHO. Indeed, sub-optimal care transitions are associated with increased mortality, morbidity and adverse events.Improving communication through timely and accurate clinical information transfer has been identified as a key component of optimal care transitions.

View Article and Find Full Text PDF

French AFU Cancer Committee Guidelines - Update 2024-2026 : Assessment of an adrenal incidentaloma and oncological management.

Fr J Urol

November 2024

Comité de Cancérologie de l'Association française d'urologie, Groupe organes génitaux externes, Maison de l'Urologie, 11, rue Viète, 75017 Paris, France; Sorbonne University, GRC 5 Predictive Onco-Uro, AP-HP, Urology, Pitié-Salpêtrière Hospital, 75013 Paris, France.

Introduction: The aim of this publication is to review the initial management procedure for adrenal incidentalomas, and where appropriate, to establish a carcinological management procedure for malignant adrenal tumours.

Materials And Methods: The multidisciplinary working group updated the CCAFU 2022 recommendations for the carcinological management of adrenal incidentalomas on the basis of a comprehensive PubMed review of the literature.

Results: Although the majority of adrenal masses are benign and nonfunctional, it is important to investigate them because of their serious endocrine potential, and because of certain cancers.

View Article and Find Full Text PDF

French AFU Cancer Committee Guidelines - Update 2024-2026: Testicular germ cell cancer.

Fr J Urol

November 2024

Comité de Cancérologie de l'Association Française d'Urologie, groupe organes génitaux externes, Maison de l'Urologie, 11, rue Viète, 75017 Paris, France; Sorbonne University, GRC 5 Predictive Onco-Uro, AP-HP, Urology, Pitié-Salpêtrière Hospital, 75013 Paris, France.

Article Synopsis
  • The objective of the review is to update guidelines for managing testicular germ cell tumors (TGT) based on recent literature from 2022.
  • Initial diagnosis involves clinical exam, serum marker levels (AFP, hCG, LDH), and imaging techniques like ultrasound and CT scans; treatment starts with inguinal orchiectomy which helps in defining the tumor stage and treatment approach.
  • For specific stages of the tumors, treatment strategies vary, including surveillance for stage I seminomas, risk-adapted options for stage I non-seminomatous tumors, and chemotherapy for metastatic cases, with additional measures like radiotherapy for certain seminoma stages.
View Article and Find Full Text PDF

French AFU Cancer Committee Guidelines-Update 2024-2026: Penile cancer.

Fr J Urol

November 2024

Comité de cancérologie de l'Association française d'urologie, groupe organes génitaux externes, Maison de l'urologie, 11, rue Viète, 75017 Paris, France; Sorbonne University, GRC 5 Predictive Onco-Uro, AP-HP, Urology, Pitié-Salpêtrière Hospital, 75013 Paris, France.

Article Synopsis
  • The objective of the study is to update guidelines for managing penile lesions and cancers.
  • A review of literature from 2022 indicates that 95% of infiltrating penile cancers are squamous cell carcinomas, often linked to HPV, and the treatment plan varies based on tumor risk classification.
  • Key recommendations emphasize the importance of evaluating lymph node involvement, using techniques like sentinel node biopsy for staging, and having surgery as the primary treatment method, sometimes alongside chemotherapy for advanced cases.
View Article and Find Full Text PDF

Bacteriological sampling in revision surgery: When, how, and with what therapeutic impact?

Orthop Traumatol Surg Res

November 2024

University of Lille, Hauts de France, F-59000 Lille, France; Northwest Reference Center for Osteoarticular Infections (Centre de Référence pour le traitement des Infections Ostéo-Articulaires Complexes Lille-Tourcoing: CRIOAC-G4), Rue Emile Laine, 59000 Lille, France; Service d'Orthopédie, Hôpital Salengro, Place de Verdun, CHU Lille, F-59000 Lille, France.

Bacteriological sampling in orthopedic revision surgery for arthroplasty or internal fixation raises several questions. 1) When? And should sampling be systematic? Sampling should not be systematic in revision surgery, but only in case of suspected infection, in which case empirical antibiotic regimen should be systematically implemented. 2) How? Which tissues, how many and what transport? Only deep samples, preferably taken without ongoing antibiotic therapy, allow reliable interpretation of results.

View Article and Find Full Text PDF

Background: The PEXIVAS (Plasma exchange and glucocorticoids in severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis) trial showed that a reduced-dose glucocorticoid regimen (redGC) was non-inferior to a standard-dose regimen (standGC) with respect to death or end-stage kidney disease (ESKD) in patients with ANCA-associated vasculitis (AAV). However, the primary endpoint did not include disease progression or relapse, cyclophosphamide was the main induction therapy and rituximab (RTX)-treated patients tended to have a higher risk of death or ESKD with redGC. We aimed to evaluate the real-world use of redGC.

View Article and Find Full Text PDF

Comparative performance analysis of Synovasure™ and Leukocyte Esterase assays for the diagnosis of periprosthetic infections in complex microbiological situations.

Orthop Traumatol Surg Res

November 2024

Centre de Référence Pour le Traitement des Infections Ostéo-Articulaires Complexes (CRIOAC), Avenue du Professeur-Emile-Laine, 59037 Lille-Tourcoing, France; Université Lille-Hauts de France, 59000 Lille, France; Service Universitaire des Maladies Infectieuses et du Voyageur, Hôpital Dron, 59200, Tourcoing, France.

Introduction: Osteoarticular infections (OAI) after prosthetic surgery have serious functional and economic consequences. Rapid tests for alpha-defensin (TAD) and leukocyte esterase (TLE) are two intra-articular markers involved in the diagnosis of OAIs. TLE cannot be applied in the presence of blood unless centrifugation is used, but the rate of "non-application" of the test for this reason is unknown in complex microbiological situations (discordant or negative puncture, ongoing antibiotic treatment).

View Article and Find Full Text PDF

Concurrent validity of Protokinetics movement analysis software for estimated centre of mass displacement and velocity during walking.

Gait Posture

January 2025

Laboratory of Industrial and Human Automation Control, Mechanical Engineering and Computer Science, UMR 8201-LAMIH, University Polytechnic Hauts-de-France, Valenciennes F-59313, France. Electronic address:

Article Synopsis
  • PKMAS, a new movement analysis software, estimates center of mass (COMe) displacement to aid in gait analysis for clinical and sports settings.
  • A study with 15 participants compared PKMAS’s COMe estimates to a more established VICON motion tracking system, revealing a significant mean bias in COMe displacement and mixed accuracy for velocity.
  • The findings suggest that while PKMAS shows some agreement in measuring displacement and velocity in certain directions, its results should be approached cautiously, especially for individuals with abnormal gait patterns.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the energy transfer properties of 2D titanium carbide MXene materials and explores their use in single-molecule biosensing for the first time.
  • DNA origami structures are employed to precisely position single dye molecules on the MXene surface, allowing for controlled experiments on energy transfer efficiency.
  • Findings demonstrate that MXenes can serve as effective nanorulers for measuring distances at the molecular level, showcasing their potential for biosensing applications that require high sensitivity to small distance changes.
View Article and Find Full Text PDF

[France's first "Pesticides and pediatric pathologies" consultation].

Rev Prat

October 2024

PériTox (UMR-I 01) ; UPJV/INERIS ; université de Picardie-Jules Verne, Amiens, France. Service de chirurgie de l'enfant, CHU Amiens-Picardie, Amiens, France.

Article Synopsis
  • France has established a new department called "Pesticides and Pediatric Pathologies" to assist children affected by severe health conditions linked to pesticide exposure.
  • This service targets families dealing with illnesses like leukemia, brain tumors, hypospadias, or cleft lip and palate where parental pesticide exposure is a factor.
  • The consultation provides support to navigate compensation options through the Pesticide Victims Compensation Fund.
View Article and Find Full Text PDF