Transanal irrigation is a better choice for bowel dysfunction in adults with Spina bifida: A randomised controlled trial.

Aim: To compare transanal irrigation with conservative bowel management for the treatment of bowel dysfunction in Spina bifida (SB) patients.

Methods: Patients with SB and bowel dysfunction were randomly assigned to receive either transanal irrigation or conservative bowel management. The effectiveness of the treatment was defined as a decrease of 4 points in the neurogenic bowel dysfunction (NBD) score at week 10.

Prevalence and risk factors for scoliosis in adults with closed and open spina bifida: A large, cross-sectional study.

Background: Scoliosis develops in a proportion of children with myelomeningocele; however, little is known about scoliosis in adulthood and in other forms of spina bifida (SB).

Objectives: The aims of this study were to describe the prevalence of scoliosis and identify risk factors for its development in a large cohort of adults with open and closed SB.

Methods: This was a cross-sectional study of data from 580 adults with SB attending their first consultation at a French multidisciplinary referral centre for SB.

Altered epithelial barrier functions in the colon of patients with spina bifida.

Our objectives were to better characterize the colorectal function of patients with Spina Bifida (SB). Patients with SB and healthy volunteers (HVs) completed prospectively a standardized questionnaire, clinical evaluation, rectal barostat, colonoscopy with biopsies and faecal collection. The data from 36 adults with SB (age: 38.

Defecation disorders in Spina Bifida: Realistic goals and best therapeutic approaches.

Aims: Spina Bifida (SB) is a rare congenital condition that frequently impairs the neurological control of both fecal continence and defecation. Several therapeutic strategies have been proposed but impact assessment is lacking. Our objectives were to quantify the symptomatic improvement and to determine the optimal strategy in this rare condition where randomized controlled trials are difficult to conduct.

Bowel Dysfunction Related to Spina Bifida: Keep It Simple.

Background: Although care of urological disorders in spina bifida is well established, there is yet no agreement on a standardized approach to bowel dysfunction in this population.

Objective: The purpose of this study was to assess bowel dysfunction using validated instruments and the risk factors in adults with spina bifida.

Design: A multidisciplinary team prospectively collected patient data, focusing on anorectal and urological symptoms.

Fecal incontinence in patients with spina bifida: The target is the rectum.

Aims: The prevalence rate of severe fecal incontinence (FI) in adults with spina bifida (SB) is high. The physiological basis of FI in SB has not been clearly established, which contributes to inadequate care. The aim was to better characterize a large cohort of adults with special consideration of anorectal physiology.

[The role of urinary markers in the assessment and follow-up of lower urinary tract disorders: a literature review].

Objectives: To conduct a literature review on the role of urinary biomarkers in the initial assessment and follow-up of lower urinary tract symptoms.

Methods: A literature review was conducted in August 2014 using the Medline/Pubmed database limiting the search to work in English or French.

Results: Most studies were of level of evidence 2 or 3 (prospective cohort, controlled or not) and mainly about overactive bladder and bladder pain syndrome.