2 results match your criteria: "Centre National de la Recherche Scientifique UPR9078[Affiliation]"
The gene encoding fibrinogen-beta is a target for retinoic acid receptor-related orphan receptor alpha.
Mol Endocrinol
October 2005
Centre National de la Recherche Scientifique UPR9078, Faculté de Médecine René Descartes Paris 5, site Necker, 75015 Paris, France.
Fibrinogen is a plasma protein synthesized by the liver. It is composed of three chains (alpha, beta, gamma). In addition to its main function as a coagulation factor, this acute phase protein is also a risk marker for atherosclerosis.
View Article and Find Full Text PDFThe gene encoding human retinoic acid-receptor-related orphan receptor alpha is a target for hypoxia-inducible factor 1.
Biochem J
November 2004
Centre National de La Recherche Scientifique UPR9078, IRNEM (Institut fédératif de recherche Necker Enfants-Malades), Faculté de Médecine Necker-Enfants Malades, 156 rue de Vaugirard, 75015 Paris, Cédex 15, France.
Retinoic acid-receptor-related orphan receptor (ROR) alpha is a nuclear receptor involved in many pathophysiological processes such as cerebellar ataxia, inflammation, atherosclerosis and angiogenesis. In the present study we first demonstrate that hypoxia increases the amount of Rora transcripts in a wide panel of cell lines derived from diverse tissues. In addition, we identified a functional promoter sequence upstream of the first exon of the human Rora gene, spanning -487 and -45 from the translation initiation site of RORalpha1.
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