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Diversifying the secretory routes in neurons.

Front Neurosci

October 2015

Cell Biology Department, Institut Curie, PSL Research University, UMR144 Paris, France ; Dynamics of Intracellular Organisation, Centre National de la Recherche Scientifique -UMR144 Paris, France.

Nervous system homeostasis and synaptic function need dedicated mechanisms to locally regulate the molecular composition of the neuronal plasma membrane and allow the development, maintenance and plastic modification of the neuronal morphology. The cytoskeleton and intracellular trafficking lies at the core of all these processes. In most mammalian cells, the Golgi apparatus (GA) is at the center of the biosynthetic pathway, located in the proximity of the microtubule-organizing center.

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