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Diagnosis of brucellosis: Combining tests to improve performance.

PLoS Negl Trop Dis

September 2024

Virulence Bactérienne et Infections Chroniques, INSERM U1047, Univ Montpellier, Service de Microbiologie et Hygiène Hospitalière, Centre National de Reference des brucelloses, CHU Nîmes, Nîmes, France.

Introduction: Brucellosis, a zoonotic infectious disease caused by bacteria of the genus Brucella, remains a significant global health concern in many parts of the world. Traditional diagnostic methods, including serological tests, suffer from limitations, including low sensibility and high false-positive rates, emphasizing the need for improved diagnostic strategies. In this study, we aimed to optimize diagnostic accuracy by reevaluating serological tests and exploring novel diagnostic algorithms.

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