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Low perforin expression in CD8+ T lymphocytes during the acute phase of severe SARS-CoV-2 infection predicts long COVID.
Front Immunol
November 2022
Institute of Human Genetics, Unité Mixte de Recherche 9002 (UMR9002), Centre National de Recherche Scientifique (CNRS) and Montpellier University, Montpellier, France.
Article Synopsis
- T cell cytotoxicity is crucial for fighting antiviral infections like SARS-CoV-2, especially in determining the severity of acute disease and the development of long COVID.
- A study measured the levels of perforin in T cells from hospitalized COVID-19 patients and found that perforin-positive T cells were more prevalent compared to healthy controls, but this did not relate to disease severity or mortality.
- Interestingly, high levels of perforin-positive T8 cells during the acute phase could predict long COVID symptoms one year later, suggesting that enhancing T cell activity early on might reduce the chances of prolonged health issues post-infection.