6 results match your criteria: "Centre National de Référence des Bordetelles[Affiliation]"

PFGE and pertactin gene sequencing suggest limited genetic variability within the Finnish Bordetella parapertussis population.

J Med Microbiol

December 2003

National Public Health Institute, Department of Human Microbial Ecology and Inflammation1 and Turku Graduate School of Biomedical Sciences, University of Turku2, Turku, Finland 3Department of Pediatrics, Turku University Hospital, Turku, Finland 4Department of Medical Microbiology, University of Turku, Turku, Finland 5Unité des Bordetella, Centre National de Référence des Bordetelles, Institut Pasteur, Paris, France.

The outer-membrane protein pertactin (Prn) of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica is believed to function as an adhesin and is an important immunogen. The emergence of B. pertussis and B.

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Because of recent concern that whole-cell pertussis vaccination can drive antigenic divergence of circulating isolates of Bordetella pertussis, we compared 12 clinical isolates of B. pertussis collected in Japan, the first country to introduce acellular pertussis vaccines, with the vaccine strain. We used pulsed-field gel electrophoresis, sequencing of ptx and prn genes and expression of fimbriae.

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Within a period of 2 1/2 years, Bordetella bronchiseptica was isolated four times from a 79-year-old woman with bronchopneumonia. We have demonstrated by pulsed-field gel electrophoresis that this infection was related to contact with infected rabbits. The initial human B.

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Bordetella pertussis expresses factors such as filamentous hemagglutinin, agglutinogens, pertactin, and pertussis toxin, which participate in bacterial adhesion; pertussis toxin, dermonecrotic toxin, lipopolysaccharide, and tracheal cytotoxin, which are responsible for toxic effects; and adenylate cyclase-hemolysin, which is required to initiate infection. By using a murine respiratory model, we showed that the RGD sequences of filamentous hemagglutinin and pertactin are important for bacterial persistence. However, mutants deficient in filamentous hemagglutinin and agglutinogens or in pertactin and the RGD sequence of filamentous hemagglutinin behaved as did wild-type B.

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