1,285 results match your criteria: "Centre Integre Universitaire de Sante et de Services Sociaux[Affiliation]"

Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability.

Nat Aging

November 2024

Translational Neuroimaging Laboratory, McGill Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Centre intégré universitaire de santé et de services sociaux de l'Ouest-de-l'Île-de-Montréal, McGill University, Montreal, Quebec, Canada.

Article Synopsis
  • Recent advancements in Alzheimer's treatment now require verification of amyloid-β pathology using PET scans or cerebrospinal fluid, but blood tests could simplify this process.* -
  • A study involving nearly 7,000 individuals identified that the plasma biomarker p-tau217 can reliably indicate amyloid-β pathology, especially in patients with probable Alzheimer’s dementia.* -
  • The findings suggest that combining p-tau217 results with clinical assessments may allow for accurate diagnoses without the need for more invasive PET or CSF tests.*
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Management of opioid use disorder: 2024 update to the national clinical practice guideline.

CMAJ

November 2024

Department of Psychology and Neuroscience (Yakovenko, Belliveau, Fraleigh, Stewart); Department of Psychiatry (Yakovenko, Stewart), Dalhousie University, Halifax, NS; Research Centre of Centre Hospitalier de l'Université de Montréal (Mukaneza, Germé), Montréal, Que.; Department of Medicine (Bach, Wood), University of British Columbia; British Columbia Centre on Substance Use (Bach, Wood), Vancouver, BC; Waypoint Centre for Mental Health Care (Poulin); Department of Psychiatry (Poulin), University of Manitoba, Winnipeg, Man.; Addictions Divisions (Selby), Centre for Addition and Mental Health; Dalla Lana School of Public Health (Selby, Rehm), University of Toronto, Toronto, Ont.; Department of Family Medicine and Emergency Medicine (Goyer, Bruneau), Université de Montréal; Centre de recherche et d'aide pour narcomanes (Goyer), Centre intégré universitaire de santé et de services sociaux du Centre-Sud-del'Île-de Montréal, Montréal, Que.; Division of General Internal Medicine (Brothers), Department of Medicine, Dalhousie University, Halifax, NS; Addiction Medicine Consult Service, Mental Health & Addictions Program (Brothers), Nova Scotia Health; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health (Rehm), Toronto, Ont.; Department of Psychology (Hodgins), University of Calgary; Department of Psychology (Hodgins), Alberta Gambling Research Institute, Calgary, Alta.; Drug addiction service (Bruneau), Centre Hospitalier de l'Université de Montréal, Montréal, Que.

Article Synopsis
  • - The 2024 update of the 2018 National Guideline for Clinical Management of Opioid Use Disorder emphasizes the need for current scientific evidence to inform treatment practices for opioid use disorder in Canada.
  • - A comprehensive review from 2017 to 2023 was conducted to revise the guidelines, involving a national committee including those with personal experience in opioid use disorder, and ensuring quality through established methods.
  • - Key changes in the recommendations include recognizing methadone and buprenorphine as equally effective first-line treatments, introducing slow-release oral morphine as a second-line option, and highlighting that psychosocial interventions should be optional rather than mandatory.
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The main objective was to document the differences between drinking times and oral perception between liquids in individuals with dysphagia. A second objective was to assess variations in consistency categorization across instruments. A third objective was to explore the relationship between drinking time and dysphagia severity.

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Unlabelled: We aimed to measure the sustainability of health professionals' intention to have serious illness conversations with patients using the Serious Illness Conversation Guide (SICG) after individual-focused training versus team-based training. In a cluster randomised trial, we trained healthcare professionals in 40 primary care clinics and measured their intention to hold serious illness conversations immediately (T1), after 1 year (T2) and after 2 years (T3). Primary care clinics ( = 40) were randomly assigned to individual-focused training (comparator) or team-based training (intervention).

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Shared decision-making with patients with complex care needs: a scoping review.

BMC Prim Care

November 2024

Department of Family Medicine and Emergency Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.

Background: A number of patients have complex care needs that arise from interactions among multiple factors, such as multimorbidity, mental health issues, and social vulnerability. These factors influence decisions about healthcare and health services. Shared decision-making (SDM), a collaborative process between patients and professionals, is known to improve the quality of the decision-making process.

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First trimester circulating miR-194-5p and miR-1278 improve prediction of preeclampsia.

Pregnancy Hypertens

October 2023

Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences (FMHS), Université de Sherbrooke, Sherbrooke, Québec, Canada; Clinical Department of Laboratory Medicine, Centre intégré universitaire de santé et de services sociaux (CIUSSS) du Saguenay-Lac-St-Jean - Hôpital Universitaire de Chicoutimi, Saguenay, Québec, Canada; Centre de Recherche du Centre hospitalier universitaire de Sherbrooke (CR-CHUS), Sherbrooke, Québec, Canada. Electronic address:

Article Synopsis
  • The study aimed to find specific circulating microRNAs in the first trimester of pregnancy that are linked to preeclampsia (PE) and evaluate their predictive power across two different groups of women.
  • Researchers analyzed plasma samples from two cohorts and identified 73 microRNAs associated with PE, narrowing down to five that showed promise when tested in the second cohort.
  • The inclusion of specific microRNAs, particularly miR-194-5p and miR-1278, improved prediction models for assessing PE risk when combined with traditional risk factors, showing a notable increase in accuracy.
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Effect of a back-support exoskeleton on internal forces and lumbar spine stability during low load lifting task.

Appl Ergon

February 2025

Institut de recherche Robert Sauvé en santé et en sécurité du travail, Montréal, Canada; Center for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR), Institut universitaire sur la réadaptation en déficience physique de Montréal (IURDPM), Centre intégré universitaire de santé et de services sociaux du Centre-Sud-de-l'Ile-de-Montréal (CCSMTL), Canada. Electronic address:

This study assessed the effect of a small-torque generating passive back-support exoskeleton during a low demanding occupational task, namely a repetitive lifting/lowering of an empty crate between the knee and shoulder heights. A comprehensive set of outcomes was considered, ranging from the measured trunk muscle activation and trunk movement to the estimated muscle group forces/coordination, spine loading and spine stability, using a dynamic subject-specific EMG-assisted musculoskeletal model. The exoskeleton decreased back muscle activation and corresponding muscle forces in the lowering phase and reduced spinal loading at larger trunk flexion angles (decreased peak compression and shear forces by ∼ 15%).

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Background And Methods: The Zéro allergie research clinic (Saguenay, Canada) is a clinical and research initiative in oral immunotherapy (OIT) for managing IgE-mediated food allergy (FA). A total of 183 children with FA and 27 non-allergic siblings were recruited to date in the Zéro allergie cohort (ZAC) to better understand biological mechanisms underlying FA and OIT prognosis. The primary aims are to (a) better understand the genetic, epigenetic, transcriptomic, metabolomic, and microbial diversity associated with FA; (b) establish the multi-omics and microbial diversity profiles of children following OIT to identify predictive prognosis biomarkers, (c) make OIT more accessible to the population of the Saguenay-Lac-Saint-Jean region, and (d) build a biobank of data and biological material.

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Background: Poststroke aphasia (PSA) recovery shows high variability across individuals and at different time points. Although diffusion biomarkers from the ventral and dorsal streams have demonstrated strong predictive power for language outcomes, it is still unclear how these biomarkers relate to the various stages of PSA recovery. In this study, we aim to compare diffusion metrics and language measures as predictors of language recovery in a longitudinal cohort of participants with PSA.

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Active play allows children to develop social and cognitive skills, which could lead to higher school engagement. Little is known about the role of child socioemotional difficulty in these associations. This study aims to examine the interaction between active play and socioemotional difficulty in childhood and their prospective association with academic engagement in adolescence.

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Introduction: The COVID-19 pandemic has had a major impact on nursing staff, resulting in alarming turnover rates. As part of the Quebec (Canada) government's response to the pandemic, nurses have been offered exceptional financial incentives. Considering the cost of these measures, the current article presents the research protocol of a study aiming to explore the impact of financial incentives on full-time equivalent, and retention rates among the nursing staff in two healthcare settings in Quebec.

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Describing Clinical Nurse Specialist Practice: A Mixed-Methods Study.

Clin Nurse Spec

October 2024

Author Affiliations: Associate Professor and Susan E. French Chair in Nursing Research and Innovative Practice(Dr Kilpatrick), Ingram School of Nursing, Faculty of Medicine and Health Sciences, McGill University; Affiliate Faculty (Dr Kilpatrick), Canadian Centre for Advanced Practice Nursing Research (CCAPNR); and Regular Researcher (Dr Kilpatrick), Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Est-de-l'Île-de-Montréal-Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada; BScN Student, Ingram School of Nursing, Faculty of Medicine and Health Sciences, McGill University, Montréal (Ms Tewah); and Full Professor and Canadian Research Chair in the Economics of Infection Prevention and Control, Département des sciences infirmières, Université du Québec en Outaouais, Saint-Jérôme, Québec, Canada (Dr Tchouaket); University Lecturer (Dr Jokiniemi), Department of Nursing Science, Faculty of Health Sciences, University of Eastern Finland, Kuopio; and Associate Professor (Dr Bouabdillah), Département des sciences infirmières, Université du Québec à Trois-Rivières, Trois-Rivières; Director of Nursing (Dr Biron), McGill University Health Centre, Montréal; Assistant to the Director of Nursing (Ms Emed), Professional Practice and Academic Affairs, Jewish General Hospital, CIUSSS du Centre-Ouest-de-l'Île-de-Montréal; and Assistant Professor (Ms Emed), Ingram School of Nursing, Faculty of Medicine and Health Sciences, McGill University, Montréal; Director of Nursing (Ms Martel), Centre hospitalier universitaire (CHU) de Québec-Université Laval; Research Administrator (Ms Atallah), Susan E. French Chair in Nursing Research and Innovative Practice, Ingram School of Nursing, Faculty of Medicine and Health Sciences, McGill University; and Research Professional (Ms Jabbour), CIUSSS de l'Est-de-l'Île-de-Montréal-Hôpital Maisonneuve-Rosemont, Montréal, Québec; and Full Professor and Alba DiCenso Chair in Advanced Practice Nursing (Dr Bryant-Lukosius), School of Nursing, Faculty of Health Sciences, and Associate Member (Dr Bryant-Lukosius), Department of Medical Oncology, Juravinski Cancer Centre, McMaster University; and Codirector (Dr Bryant-Lukosius), Canadian Centre for Advanced Practice Nursing Research, and Health Sciences Centre, Hamilton, Ontario, Canada.

Purpose/aims: To describe clinical nurse specialist practice in Québec, Canada, and propose a dashboard to track role dimensions and outcomes.

Design: Sequential mixed-methods study across 6 sites in Québec (June 2021 to May 2022).

Methods: Phase 1: Focus groups (n = 8) and individual interviews (n = 3) were conducted to adapt a time and motion tool.

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Article Synopsis
  • - The metabolic syndrome (MetS) is a significant risk factor for serious health issues like cardiovascular disease and type 2 diabetes, and its rising prevalence due to lifestyle changes stresses the need for urgent action.
  • - Understanding MetS requires examining various factors such as genetic predisposition, insulin resistance, and inflammation, with common diagnostic tools focusing on abdominal obesity and related health indicators.
  • - Management of MetS emphasizes lifestyle changes like diet and exercise, alongside exploring new treatments, while the Primer advocates for a comprehensive approach involving clinicians, researchers, and policymakers to effectively address this public health challenge.
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Recommendations on the use of artificial intelligence in health promotion.

Prog Cardiovasc Dis

December 2024

HealthPartners Institute, Minneapolis, MN, USA; University of Minnesota, Dept. of Health Policy and Management, Minneapolis, MN, USA.

Article Synopsis
  • * A philosophical inquiry was conducted, exploring key questions about the relationship between humans and AI, trust issues, ethical concerns, and control of AI in health contexts.
  • * The resulting 11 recommendations emphasize a human-centric approach, suggesting workforce planning that incorporates AI and the importance of reporting serious AI-related incidents to regulatory authorities.
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Care trajectories and transitions at the end of life: a population-based cohort study.

Age Ageing

October 2024

Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.

Article Synopsis
  • End-of-life periods for people over 65 often involve ineffective use of healthcare services, impacting their health and quality of life, which hasn't been extensively studied.
  • The objective of this study was to categorize the care trajectories and transitions for older adults in the two years before they pass away, based on data from a health cohort study in Canada.
  • Researchers identified five distinct care trajectory groups, noting varying patterns of healthcare use, especially an increase near the end of life, with many individuals dying in hospitals and a notable proportion receiving palliative care.
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Background: Cannabis use can generate potential avoidable harms, hence the need for effective preventive measures and treatment. Studies show the efficacy of harm reduction (HR) in minimizing undesirable consequences associated with this use. Despite its proven efficacy, HR in cannabis use remains poorly applied by many health and social services (HSS) practitioners, especially with young people.

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Article Synopsis
  • Researchers explored the differences between "brain-first" and "body-first" types of Parkinson's disease by studying patients with isolated REM sleep behavior disorder (iRBD) and their periodic limb movements during sleep (PLMS).
  • Out of the 191 patients examined, 48.2% had a high PLMS index (PLMSi > 15), which was linked to better performance in executive functions despite poorer sleep quality.
  • The study suggests that higher PLMSi correlates with increased wakefulness and decreased overall sleep efficiency, indicating a potential connection between sleep disruptions and cognitive status in these patients.
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Background: Safety remains a significant concern for biologic drugs, and studies are needed to ensure a comparable safety profile for biosimilars and their legacy treatments. Using Canadian administrative health data from 2015-2019, we compared the incidence of serious infection between biosimilars and bio-originators initiators for etanercept and infliximab, two of the most commonly used biologics during this time.

Methods: We performed a retrospective cohort study using pan-Canadian data (except Quebec) from the National Prescription Drug Utilization Information System linked to hospitalization data.

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: Physical activity is an important protective factor throughout life. However, little research has observed the associations between the practice of physical activity and academic success longitudinally, and none have done so with a pan-Canadian sample. This article aims to examine the prospective associations between active leisure in middle childhood and academic achievement in emerging adulthood, for both boys and girls, beyond several family factors.

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Introduction: Worldwide, one in six individuals live with a disability. Many people continue to experience disabling situations, particularly when travelling. Travel can be an important part of the lives of many people, including people with disabilities.

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Very few empirically validated tools exist for assessing reactive attachment disorder (RAD) and disinhibited social engagement disorder (DSED). The RAD and DSED assessment interview (RADA), a semistructured diagnostic interview, was updated in 2018 from the CAPA-RAD interview to reflect the diagnostic criteria changes in the (5th ed.; ).

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Rationale: Practice context is known to influence the deployment of competencies. The COVID-19 pandemic created a major disruption in many practice contexts. The objective was to understand the lived experience of rehabilitation clinicians during a major disruption of their practice context, namely, the COVID-19 pandemic.

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