1,285 results match your criteria: "Centre Integre Universitaire de Sante et de Services Sociaux[Affiliation]"

Oculopharyngeal muscular dystrophy (OPMD) is a rare late-onset muscle disease with progressive dysphagia as a major symptom. The Dysphagiameter is a newly developed patient-reported outcome measure (PROM) to assess the severity of dysphagia and its impact in patients with OPMD. This article reports on item reduction and a first assessment of the Dysphagiameter's psychometrics properties, in a French and English-speaking population of individuals with OPMD.

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People living with chronic pain in Canada face difficult decisions and decisional conflict concerning their care: data from the national DECIDE-PAIN survey.

BMC Prim Care

December 2024

Université de Sherbrooke, Faculty of Medecine and Health Sciences, School of Rehabilitation, Research Centre of the CHUS, CIUSSS de l'Estrie-CHUS, Sherbrooke, Canada.

Background: Shared decision-making is an imperative in chronic pain care. However, we know little about the decision-making process, especially in primary care where most chronic pain care is provided. We sought to understand decisional needs of people living with chronic pain in Canada.

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 The absence of standardized reporting for sleep medicine exams across different laboratories can lead to misinterpretation, diagnostic inconsistencies, and suboptimal treatment strategies. This document seeks to establish guidelines for the development of sleep study reports, covering recordings from studies of types 1 to 4, and represents the official position of Associação Brasileira do Sono (ABS; Brazilian Sleep Association) on the standardization of polysomnography (PSG) and cardiorespiratory polygraphies.  The recommendations for the items to be reported in PSG records were developed by means of a Delphi study, comprised of two voting rounds.

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Treatment Approaches to Myasthenia Gravis and Obstructive Sleep Apnea: Case Report.

Sleep Sci

December 2024

Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil.

Article Synopsis
  • Myasthenia gravis (MG) is an autoimmune disease that causes muscle weakness due to the destruction of acetylcholine receptors at the neuromuscular junction.
  • Treatment for patients with both MG and obstructive sleep apnea (OSA) often includes positive pressure airway therapy, but adherence to this treatment can be challenging, leading to worse health outcomes.
  • This report focuses on a case study of a 50-year-old man with MG and OSA, examining how he responded to various treatment methods.
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Introduction: Unintentional therapeutic errors with bupropion are common. The impact of the timing of the second dose in a double dose exposure on adverse effects is not well studied. This study aims to compare adverse effects between double doses separated by <720 min and ≥720 min.

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Background Researcher and psychologist Kieron Philip O'Connor (1950-2019) pioneered the cognitive and behavioural approach at the Institut universitaire en santé mentale de Montréal (IUSMM). It was there that he began a career as a clinical researcher studying Tourette's syndrome (TS) and obsessive-compulsive and related disorder (OCD). At the time, apart from some behavioural approaches, little cognitive intervention was available to treat chronic tics and obsessive-compulsive disorder.

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Community-based physical activity programmes benefit persons with disabilities. However, there is a lack of evidence-based tools to support kinesiologists' training in such programmes. This study aimed to co-create and evaluate physical activity training modules for community-based adapted physical activity (APA) programmes.

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Background: Previous systematic reviews on fracture and fall prevention have generally shown no efficacy with calcium or vitamin D alone and conflicting findings with that of vitamin D combined with calcium. Despite these findings, increases in vitamin D and calcium prescriptions have been reported in many countries, as many clinicians, guidelines and regulatory agencies still largely recommend universal supplementation to adults.

Methods And Analysis: We will conduct a systematic review of randomised controlled trials on the efficacy of vitamin D and/or calcium in fracture and fall prevention.

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Objective: Suboptimal primary health care management of shoulder pain has been reported in previous studies. Implementing clinical practice guidelines (CPGs) recommendations using a theoretical approach is recommended to improve shoulder pain management. This study aims to identify determinants of implementing recommendations from shoulder CPGs to help develop an intervention based on the identified determinants.

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Background: Impaired growth in childhood can lead to poor cognitive development and low school performance. However, literature on the effects of stunting on school trajectory is very limited. The primary objective of this research was to estimate the age at which children start school according to levels of height-for-age z-score (stunting).

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Background: A significant proportion of individuals with disabilities in resource-limited countries require at least 1 assistive technology (AT) device to enhance their functioning and autonomy. However, there is limited evidence regarding the actual needs of AT users in these regions concerning the adequacy of ATs.

Objective: This research aims to assess the effects of ATs on AT users in a resource-limited country.

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Introduction: In 2011, the Canadian Institutes of Health Research launched a Strategy for Patient-Oriented Research (POR) for healthcare and academic institutions to increase patient participation in health research. POR considers patients and caregivers as partners with scientific investigators, healthcare professionals and administrative decision-makers. As POR becomes a standard worldwide, the how-to, practical aspects of POR integration in healthcare institutions remain uncharted territory.

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Tabletop Simulations in Medical Emergencies: A Scoping Review.

Simul Healthc

December 2024

From the Université de Montréal, Montréal, Québec, Canada (A.F., B.V., A.L., M.-A.M.-C., V.C., R.F.-S., Z.G.-T., S.B., L.-P.V., D.H.-J., F.L., M.I., R.D., S.C., A.C.); Hôpital du Sacré-Cœur de Montréal, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord-de-l'Île-de-Montréal, Montréal, Canada (A.F., V.C., Z.G.-T., S.B., L.-P.V., D.H.-J., F.L., R.D., A.C.); Hôpital de Saint-Eustache, Centre Intégré de Santé et de Services Sociaux des Laurentides, St-Eustache, Québec Canada (A.F., R.F.-S.); Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, Canada (B.V.); Center for Implementation Research, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (G.F.); Jewish General Hospital's Center for Nursing Research, Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Ouest-de-l'Île-de-Montréal, Montréal, Québec, Canada (G.F.); Hôpital Maisonneuve-Rosemont, Centre Intégré Universitaire de Santé et de Services Sociaux de l'Est-de-l'Île-de-Montréal, Montréal, Québec, Canada (M.I., A.C.); Centre de Recherche de l'Institut de Cardiologie de Montréal, Montréal, Québec, Canada (S.C.); Université de Genève, Genève, Suisse (M.B.); Hôpitaux Universitaires de Genève, Genève, Suisse (M.B.); Université Laval, Québec, Québec, Canada (R.F.); Hôpital de Lévis, Centre Intégré de Santé et de Services Sociaux de Chaudières-Appalaches, Lévis, Québec, Canada (R.F.); and Corporation d'Urgences-Santé, Montréal, Québec, Canada (A.C.).

Tabletop simulations (TTS) are a novel educational modality used in health care education. The objective of this scoping review was to describe the use of TTS in medical emergencies, specifically settings, specialties, participants, formats, and outcomes.We included 70 studies (33 descriptive studies [47%], 33 cohort studies [47%], and 2 randomized controlled trials [3%]), of which 65 reported positive results regarding reaction and learning educational outcomes (reaction: n = 37, 53%; learning: n = 25, 36%; behavior: n = 7, 10%; result: n = 1, 1%).

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Patient-Relevant Digital-Motor Outcomes for Clinical Trials in Hereditary Spastic Paraplegia Type 7: A Multicenter PROSPAX Study.

Neurology

December 2024

Division Translational Genomics of Neurodegenerative Diseases (L.B., A.T., D.M., M.S.), Hertie-Institute for Clinical Brain Research and Center for Neurology, and German Center for Neurodegenerative Diseases (DZNE) (L.B., A.T., D.M., K.D.-J., M.S., R.S.), University of Tübingen; Section Computational Sensomotorics (J.S., W.I.), Hertie Institute for Clinical Brain Research; Centre for Integrative Neuroscience (CIN) (J.S., W.I.); Department of Neurodegenerative Diseases (C.K.), Hertie-Institute for Clinical Brain Research and Center for Neurology, University of Tübingen; Center for Neurology and Hertie Institute for Clinical Brain Research (K.D.-J., R.S.), University Hospital Tübingen, Germany; Molecular Medicine (I.R., S.S.), IRCCS Fondazione Stella Maris, Pisa, Italy; Koç University (N.A.B.), Translational Medicine Research Center, KUTTAM-NDAL, Istanbul, Turkey; Sorbonne Université (G.C.), Paris Brain Institute, INSERM, CNRS, APHP, France; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (D.T.), University Hospital Essen, University of Duisburg-Essen, Germany; Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN) (C.G.), Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-St-Jean; Centre de recherche du Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-St-Jean (C.G.); Faculté de médecine et des sciences de la santé (C.G.), Université de Sherbrooke, Québec, Canada; Department of Neurology (B.P.C.v.d.W.), Radboud University Medical Center, Nijmegen, the Netherlands; and Division of Neurodegenerative Diseases (R.S.), Department of Neurology, Heidelberg University Hospital, Germany.

Article Synopsis
  • The study focuses on identifying valid digital-motor outcome measures using wearable sensors for spastic paraplegia type 7 (SPG7), a common spastic ataxia, aiming to reflect health aspects relevant to patients in early disease stages and suitable for multicenter trials.
  • Gait analysis was performed in 65 SPG7 patients and 50 healthy controls, where 18 out of 30 analyzed gait measures effectively discriminated between the two groups, even in mild disease stages.
  • Key findings highlighted that specific spatiotemporal variability measures strongly correlate with functional mobility and overall disease severity, indicating their potential as sensitive outcome measures for future trials.
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Improving Gout Care in a Canadian Academic Medical Center Through a Multidisciplinary, Nurse-Led Protocol.

J Rheumatol

March 2025

P. Dagenais, MD, PhD, Department of Medicine, Rheumatology Division, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.

Objective: Following Health Canada's knowledge translation framework, we report the results of a clinical audit from 2012 to 2015 followed by a multidisciplinary, nurse-led gout care protocol with a treat-to-target (T2T) strategy implemented in April 2018.

Methods: A clinical audit with chart reviewing was completed for adults with gout and urate-lowering therapy (ULT) indication at the Centre Hospitalier Universitaire de Sherbrooke. A nurse-led treatment algorithm using allopurinol was then developed.

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Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses.

Nat Biomed Eng

November 2024

Department of Microbiology and Infectiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke Cancer Research Institute, Université de Sherbrooke, Sherbrooke, Québec, Canada.

Article Synopsis
  • Optimizing oncolytic viruses for cancer treatment involves removing harmful genes and adding new ones to improve their ability to replicate and stimulate immune responses.
  • The complex nature of viral genomes and the difficulty of creating modified viruses have slowed progress in developing these therapies.
  • Researchers used a novel strategy involving antibiotics, transposon systems, and advanced sequencing to efficiently engineer safer and more effective oncolytic viruses by identifying useful genetic changes.
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Purpose: Hematopoietic cell transplantation (HCT) is a common treatment for people diagnosed with hematological cancers. However, it can cause side effects that may affect work participation. This scoping review aims to provide an overview of the factors that influence the work participation of hematological cancer survivors who have undergone HCT.

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Background: Scaling is typically discussed as a way to amplify or expand a health innovation. However, there is limited knowledge about the specific techniques that can enhance access to or improve the quality of innovations, aiming to increase their positive impacts for the public good. We sought to identify, compare, and contrast scaling frameworks to advance the science and practice of scaling.

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Addressing the topic of death is essential to empower healthcare professionals to work with people, but there is a lack of training in this area. This study presents the perceptions of students and educators regarding the use of metaphor and artistic creation to explore values, prejudices, emotions, and experiential knowledge related to death. The pedagogical innovation allowed students to reflect on and express their perceptions of death, while also experiencing a listening posture, thereby contributing to the development of communication skills, among others.

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Article Synopsis
  • Many patients visit the emergency department (ED) for musculoskeletal disorders, leading some hospitals to allow physiotherapists to manage these cases independently after initial triage.
  • A study analyzing data from a randomized clinical trial found that physiotherapists and emergency physicians had a high diagnostic agreement of 86.1%, with almost perfect concordance (Gwet's AC1: 0.84).
  • The main disagreement was that physiotherapists often suspected fractures, while emergency physicians identified ligament or meniscus issues, indicating a need for further research with a broader diagnosis range and diverse patient demographics.
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Article Synopsis
  • The study aimed to compare the quality of life (QoL) between prostate cancer patients who recover testosterone levels after androgen deprivation therapy (ADT) and those who do not.
  • The analysis involved 494 patients from a Phase III trial, looking at QoL measurements over time, with findings showing that patients with testosterone recovery reported a significantly better QoL compared to those without recovery.
  • Results indicated that testosterone recovery occurred faster in patients who underwent a shorter 18-month ADT regimen, and this recovery was linked to improvements in various QoL measures.
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Regional primary preadipocyte characteristics in humans with obesity and type 2 diabetes mellitus.

Heliyon

November 2024

Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, Quebec, Canada.

The excessive accumulation of adipose tissue in obesity appears to result in adipose tissue dysfunction perpetuating the onset of obesity-related diseases, including type 2 diabetes (T2DM). In humans, adipose tissue is stored in several depots including subcutaneous and visceral. These depots contribute to the pathology of obesity differently owing to differences in the tissue microenvironment, a main one being preadipocyte function.

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Background: Over 50% of individuals with aphasia face ongoing word-finding issues. Studies have found phonologically oriented therapy helpful for English speakers, but this has not yet been studied in French. It is essential to assess the effectiveness of such a therapy in French, considering the distinct linguistic typologies between both languages, which may impact the outcomes of phonologically oriented interventions.

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Editorial: Insights in Cushing's syndrome and disease, volume II.

Front Endocrinol (Lausanne)

October 2024

Department of Medicine, Division of Endocrinology, Centre Intégré Universitaire de Santé et de Services Sociaux de l'Estrie, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.

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"How can we help you?": results of a scoping review on the perceived needs of people living with chronic pain regarding physiotherapy.

BMC Health Serv Res

November 2024

School of rehabilitation, Faculty of medicine, Université de Montréal, PO Box 6128, Centre-Ville, Montreal, QC, H3C 3J7, Canada.

Background: Physiotherapy is effective to reduce pain and improve the quality of life of people living with chronic pain. To offer high-quality physiotherapy services, these services must be patient-centred and respond to patients' needs. However, few studies seem to target patients' perceived needs, whereas more studies tend to focus on needs assessed by healthcare experts, which are not always in line with patients' perceived needs.

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