One- or Two-Step Total Thyroidectomy for Cancer Indications: A 20-Year Retrospective Study from a Referral Center.

Background: The ATA guidelines suggest lobectomy as an option for select patients with thyroid cancer (TC), but some may need completion thyroidectomy because of unfavorable characteristics on the final pathology. This study aimed to compare postoperative morbidity of patients with TC who underwent total thyroidectomy in two steps (TT2) or one step (TT1).

Methods: This was a retrospective comparative study in a high-volume endocrine surgery center.

Evolution of minimally invasive liver surgery in France over the last decade.

Background: Despite evidence of benefits on postoperative outcomes, minimally invasive liver surgery (MILS) had a very low diffusion up to 2014, and recent evolution is unknown. Our aim was to analyze the recent diffusion and adoption of MILS and compare the trends in indications, extent of resection, and institutional practice with open liver surgery (OLS).

Methods: We analyzed the French nationwide, exhaustive cohort of all patients undergoing a liver resection in France between January 1, 2013 and December 31, 2022.

Clinical care pathways of patients with biliary tract cancer: A French nationwide longitudinal cohort study.

Background: Although the incidence of BTC is raising, national healthcare strategies to improve care lack. We aimed to explore patient clinical care pathways and strategies to improve biliary tract cancer (BTC) care.

Methods: We analysed the French National Healthcare database of all BTC inpatients between January 1, 2017 and December 31, 2021.

Optimal Transport Reconstruction of Baryon Acoustic Oscillations.

A weighted, semidiscrete, fast optimal transport (OT) algorithm for reconstructing the Lagrangian positions of protohalos from their evolved Eulerian positions is presented. The algorithm makes use of a mass estimate of the biased tracers and of the distribution of the remaining mass (the "dust") but is robust to errors in the mass estimates. Tests with state-of-art cosmological simulations show that if the dust is assumed to have a uniform spatial distribution, then the shape of the OT-reconstructed pair correlation function of the tracers is very close to linear theory, enabling subpercent precision in the baryon acoustic oscillation distance scale that depends weakly, if at all, on a cosmological model.

Association between the LRP1B and APOE loci and the development of Parkinson's disease dementia.

Parkinson's disease is one of the most common age-related neurodegenerative disorders. Although predominantly a motor disorder, cognitive impairment and dementia are important features of Parkinson's disease, particularly in the later stages of the disease. However, the rate of cognitive decline varies among Parkinson's disease patients, and the genetic basis for this heterogeneity is incompletely understood.

Automatic segmentation of white matter hyperintensities: validation and comparison with state-of-the-art methods on both Multiple Sclerosis and elderly subjects.

Different types of white matter hyperintensities (WMH) can be observed through MRI in the brain and spinal cord, especially Multiple Sclerosis (MS) lesions for patients suffering from MS and age-related WMH for subjects with cognitive disorders and/or elderly people. To better diagnose and monitor the disease progression, the quantitative evaluation of WMH load has proven to be useful for clinical routine and trials. Since manual delineation for WMH segmentation is highly time-consuming and suffers from intra and inter observer variability, several methods have been proposed to automatically segment either MS lesions or age-related WMH, but none is validated on both WMH types.

Multiscale mathematical modeling of the hypothalamo-pituitary-gonadal axis.

Although the fields of systems and integrative biology are in full expansion, few teams are involved worldwide into the study of reproductive function from the mathematical modeling viewpoint. This may be due to the fact that the reproductive function is not compulsory for individual organism survival, even if it is for species survival. Alternatively, the complexity of reproductive physiology may be discouraging.

Multi-scale modelling of ovarian follicular development: From follicular morphogenesis to selection for ovulation.

In this review, we present multi-scale mathematical models of ovarian follicular development that are based on the embedding of physiological mechanisms into the cell scale. During basal follicular development, follicular growth operates through an increase in the oocyte size concomitant with the proliferation of its surrounding granulosa cells. We have developed a spatio-temporal model of follicular morphogenesis explaining how the interactions between the oocyte and granulosa cells need to be properly balanced to shape the follicle.