84 results match your criteria: "Centre INRIA de l'Université de Rennes[Affiliation]"

Polypharmacy (PP) and hyperpolypharmacy (HPP), are prevalent among cancer patients and are associated with an increased risk of drug-drug interactions (DDI) and potentially inappropriate medications (PIM). This study aimed to characterize PP, HPP, DDI, and PIM in patients with hematological malignancies hospitalized for hematopoietic stem cell transplantation (HSCT) by introducing a novel metric: cumulative drug exposure. Clinical data warehouse (CDW) records were employed to develop algorithms that quantified patients' cumulative exposure to these prescribing determinants during hospitalization.

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  • * Using a cohort of over 3,600 participants, researchers measured levels of specific antibodies and assessed SARS-CoV-2 infection outcomes over the next six months.
  • * Results showed that higher anti-Spike IgG antibody levels correlated with reduced infection risk in the control group, but this was not the case for individuals in specific patient populations.
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Background: Choroid plexus (ChP) enlargement is an emerging radiological biomarker in multiple sclerosis (MS).

Objectives: This study aims to assess ChP volume in a large cohort of patients with radiologically isolated syndrome (RIS) versus healthy controls (HC) and explore its relationship with other brain volumes, disease activity, and biological markers.

Methods: RIS individuals were included retrospectively and compared with HC.

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  • A study analyzed the impact of status epilepticus (SE) on in-hospital mortality and costs using a large French health insurance database from 2015 to 2019, focusing on patient demographics, causes, and healthcare expenses.
  • Among 52,487 patients, 21.8% died in the hospital, with increasing mortality risks associated with older age, acute causes, tumors, and multiple comorbidities, while mechanical ventilation also significantly affected mortality.
  • The average cost per SE hospitalization was around €6,517, highlighting a strong correlation between factors leading to higher mortality and increased healthcare costs, indicating a need for further research on long-term implications.
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Meta-analyses of phase I dose-finding studies: Application for the development of protein kinase inhibitors in oncology.

Res Synth Methods

November 2024

Univ Rennes, CHU Rennes, Inserm, Centre d'investigation clinique de Rennes (CIC1414), Service de Pharmacologie Clinique, Institut de Recherche en Santé, Environnement et Travail (Irset), UMR S 1085, EHESP, Rennes, France.

This study aimed to assess the feasibility of applying two recent phase I meta-analyses methods to protein kinase inhibitors (PKIs) developed in oncology and to identify situations where these methods could be both feasible and useful. This ancillary study used data from a systematic review conducted to identify dose-finding studies for PKIs. PKIs selected for meta-analyses were required to have at least five completed dose-finding studies involving cancer patients, with available results, and dose escalation guided by toxicity assessment.

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Background: This study aimed to compare the humoral responses to mRNA COVID-19 vaccination in people living with HIV (PWH) and HIV-negative individuals.

Methods: We included PWH with an undetectable viral load under ART and HIV-negative participants from the French nationwide ANRS COV-POPART cohort who had received two doses of vaccine as a primary vaccination. We compared humoral response between controls and PWH, stratified by CD4 cell count (<200/mm and ≥200/mm CD4 cell counts) at 1, 6, and 12 months after primary vaccination.

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Quantifying Apathy in Late-Life Depression: Unraveling Neurobehavioral Links Through Daily Activity Patterns and Brain Connectivity Analysis.

Biol Psychiatry Cogn Neurosci Neuroimaging

July 2024

Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France; Centre d'Investigation Clinique 1414, Centre Hospitalier Universitaire de Rennes, Institut National de la Santé et de la Recherche Médicale (INSERM), Rennes, France; Université de Rennes, Inria, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France; Faculté de Médecine, Rennes Université, Rennes, France.

Article Synopsis
  • A study explored the links between motor activity patterns, apathy, and brain connectivity in older adults with late-life depression to improve predictions for conditions like dementia.
  • Using actimetry, resting-state fMRI, and diffusion MRI, researchers assessed 38 participants and identified two key activity patterns related to apathy: mean diurnal activity and early chronotype.
  • The study found that both patterns were associated with notable brain network connectivity but did not establish a significant connection with microstructural brain metrics.
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Structural Brain Connectivity and Treatment Improvement in Mood Disorder.

Brain Connect

May 2024

Univ Rennes, Inria, CNRS, IRISA, INSERM, Empenn U1228 ERL, Rennes, France.

The treatment of depressive episodes is well established, with clearly demonstrated effectiveness of antidepressants and psychotherapies. However, more than one-third of depressed patients do not respond to treatment. Identifying the brain structural basis of treatment-resistant depression could prevent useless pharmacological prescriptions, adverse events, and lost therapeutic opportunities.

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Generators of space-time dynamics in bioimaging have become essential to build ground truth datasets for image processing algorithm evaluation such as biomolecule detectors and trackers, as well as to generate training datasets for deep learning algorithms. In this contribution, we leverage a stochastic model, called birth-death-move (BDM) point process, in order to generate joint dynamics of biomolecules in cells. This particle-based stochastic simulation method is very flexible and can be seen as a generalization of well-established standard particle-based generators.

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In July 2023, the Center of Excellence in Respiratory Pathogens organized a two-day workshop on infectious diseases modelling and the lessons learnt from the Covid-19 pandemic. This report summarizes the rich discussions that occurred during the workshop. The workshop participants discussed multisource data integration and highlighted the benefits of combining traditional surveillance with more novel data sources like mobility data, social media, and wastewater monitoring.

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Background: Epidemiological data reveal that 45% of persons with multiple sclerosis (PwMS) in France are more than 50 years. This population more than 50 is more susceptible to cancer, and this risk may be increased by frequent use of immunosuppressive drugs. Consequently, concerns have arisen about the potential increased risk of cancer in PwMS and how patients should be screened and managed in terms of cancer risk.

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Increasing evidence shows that flaws in machine learning (ML) algorithm validation are an underestimated global problem. In biomedical image analysis, chosen performance metrics often do not reflect the domain interest, and thus fail to adequately measure scientific progress and hinder translation of ML techniques into practice. To overcome this, we created Metrics Reloaded, a comprehensive framework guiding researchers in the problem-aware selection of metrics.

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Validation metrics are key for tracking scientific progress and bridging the current chasm between artificial intelligence research and its translation into practice. However, increasing evidence shows that, particularly in image analysis, metrics are often chosen inadequately. Although taking into account the individual strengths, weaknesses and limitations of validation metrics is a critical prerequisite to making educated choices, the relevant knowledge is currently scattered and poorly accessible to individual researchers.

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Global exact optimisations for chloroplast structural haplotype scaffolding.

Algorithms Mol Biol

February 2024

GenScale, Centre Inria de l'Université de Rennes, IRISA, 263 Avenue Général Leclerc, 35700, Rennes, France.

Background: Scaffolding is an intermediate stage of fragment assembly. It consists in orienting and ordering the contigs obtained by the assembly of the sequencing reads. In the general case, the problem has been largely studied with the use of distances data between the contigs.

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[Management of an amnesic patient].

Rev Prat

December 2023

CHU de Rennes, service de neurologie, centre mémoire de ressources et de recherche, Rennes ; Inria, CNRS, Inserm, IRISA UMR 6074, Empenn U1228, université de Rennes, Rennes, France.

MANAGEMENT OF AN AMNESIC PATIENT. Until the early 1980s, neuropsychological rehabilitation of amnesic syndromes was limited to extensive repeated practice ('cognitive drill'). The ineffectiveness of these methods is now acknowledged, if the therapeutic target concerns daily life.

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Connectivity patterns of the core resting-state networks associated with apathy in late-life depression.

J Psychiatry Neurosci

November 2023

From the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David).

Background: Apathy is associated with reduced antidepressant response and dementia in late-life depression (LLD). However, the functional cerebral basis of apathy is understudied in LLD. We investigated the functional connectivity of 5 resting-state networks (RSN) hypothesized to underlie apathy in LLD.

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  • The study investigates fluid intake in ICU patients at risk of negative outcomes due to excessive fluid balance, highlighting the need for fluid optimization beyond traditional resuscitation.
  • Conducted across multiple ICUs in France and Spain, it recorded the types and volumes of fluids administered to patients needing vasopressors or invasive ventilation over a 24-hour period.
  • Results indicate that only 36% of the total fluid volume was essential for body fluid homeostasis, with significant variations in fluid administration based on the specific ICU, suggesting a strong center effect on fluid management practices.
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We present and share a large database containing electroencephalographic signals from 87 human participants, collected during a single day of brain-computer interface (BCI) experiments, organized into 3 datasets (A, B, and C) that were all recorded using the same protocol: right and left hand motor imagery (MI). Each session contains 240 trials (120 per class), which represents more than 20,800 trials, or approximately 70 hours of recording time. It includes the performance of the associated BCI users, detailed information about the demographics, personality profile as well as some cognitive traits and the experimental instructions and codes (executed in the open-source platform OpenViBE).

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Assessment of minimal residual disease in acute lymphoblastic leukemia by immune repertoire NGS requires spiking CDR3 sequences at known quantities into the patient's sample. Recently, the EuroClonality-NGS group released one of the most comprehensive protocols for this purpose. ARResT/Interrogate is a closed-source software for processing these NGS libraries, developed by this same group.

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Multi T1-weighted contrast imaging and T1 mapping with compressed sensing FLAWS at 3 T.

MAGMA

October 2023

Univ Rennes, CRLCC Eugene Marquis, Inserm, LTSI-UMR1099, LTSI, Campus de Beaulieu, Université de Rennes 1, 35042, Rennes, France.

Objective: The Fluid And White matter Suppression (FLAWS) MRI sequence provides multiple T1-weighted contrasts of the brain in a single acquisition. However, the FLAWS acquisition time is approximately 8 min with a standard GRAPPA 3 acceleration factor at 3 T. This study aims at reducing the FLAWS acquisition time by providing a new sequence optimization based on a Cartesian phyllotaxis k-space undersampling and a compressed sensing (CS) reconstruction.

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Article Synopsis
  • The study aims to utilize advanced computational tools to improve the management of multiple sclerosis (MS), particularly for relapsing-remitting MS (RRMS) patients.
  • Researchers analyzed phase 3 clinical trial data to compare the effectiveness of peg-interferon beta-1a against a placebo using various measures of disease activity.
  • They created a prototype decision support system called MS Vista that personalizes treatment efficacy information for patients and enhances communication between healthcare providers and patients.
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One-month humoral response following two or three doses of messenger RNA coronavirus disease 2019 vaccines as primary vaccination in specific populations in France: first results from the Agence Nationale Recherche contre le Sida (ANRS)0001S COV-POPART cohort.

Clin Microbiol Infect

March 2023

INSERM, F-CRIN, Reseau Innovative Clinical Research in Vaccinology (IREIVAC), Paris, France; Centre d'Investigation Clinique Cochin Pasteur, Hôpital Cochin/APHP, INSERM CIC 1417, Paris, France; Université de Paris, Paris, France.

Objectives: We aimed to investigate the 1-month humoral response to two or three doses of a messenger RNA coronavirus disease 2019 (COVID-19) vaccine as a primary vaccination regimen in specific populations compared with that in healthy adults.

Methods: Agence Nationale Recherche contre le Sida (ANRS)0001S-COV-POPART (NCT04824651) is a French nation-wide, multi-centre, prospective, observational cohort study assessing the immune response to COVID-19 vaccines routinely administered to 11 sub-groups of patients with chronic conditions and two control groups. Patients and controls who received at least two vaccine doses and whose results 1 month after the second dose were available were included.

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