1 results match your criteria: "Centre Hospitalier et Universitaire (CHU) Rangueil[Affiliation]"
Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-gamma production by invariant natural killer T cells.
Blood
March 2005
Institut National de la Santé et de la Recherche Médicale (INSERM) U589, Institut L. Bugnard, Centre Hospitalier et Universitaire (CHU) Rangueil, Toulouse, France.
Article Synopsis
- The mechanisms behind how gender affects immune responses are not well understood, particularly regarding the role of invariant natural killer T (iNKT) cells and their cytokine production.
- Research found that female mice produced significantly higher levels of interferon gamma (IFN-gamma) in response to the iNKT cell ligand alpha-galactosylceramide (alpha-GalCer) compared to male mice, indicating a hormone influence on immune responses.
- The study demonstrated that ovarian hormones, specifically estrogens, enhance IFN-gamma production in iNKT cells, suggesting that these hormones contribute to gender differences in immune responses.