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163 results match your criteria: "Centre Hospitalier Universitaire de Sherbrooke (CHUS)[Affiliation]"
Front Cell Dev Biol
November 2024
Department of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
J Soc Cardiovasc Angiogr Interv
November 2024
Population Health Research Institute, Hamilton, Ontario, Canada.
J Rheumatol
December 2024
P. Dagenais, MD, PhD, Department of Medicine, Rheumatology Division, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Objective: Following Health Canada's knowledge translation framework, we report the results of a clinical audit from 2012 to 2015 followed by a multidisciplinary, nurse-led gout care protocol with a treat-to-target (T2T) strategy implemented in April 2018.
Methods: A clinical audit with chart reviewing was completed for adults with gout and urate-lowering therapy (ULT) indication at the Centre Hospitalier Universitaire de Sherbrooke. A nurse-led treatment algorithm using allopurinol was then developed.
Curr Oncol
November 2024
Department of Hemato-Oncology, Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke University, Sherbrooke, QC J1H-5N4, Canada.
Background: Immunotherapy is the cornerstone of treatment for many cancers. The effectiveness of immunotherapy in hospitalized patients is unknown due to the exclusion of this fragile population from clinical trials. This study evaluates the efficacy of immunotherapy in fragile hospitalized patients.
View Article and Find Full Text PDFAppl Physiol Nutr Metab
October 2024
School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Musculoskeletal injury (MSKi), depression, anxiety, and burnout place a considerable burden on emergency services personnel and healthcare providers (HCP). Physical fitness is related to both mental and physical health in these populations, but females in these are hugely underrepresented in this literature. As female representation in first-responder and HCP roles increases, the need for female-specific research is needed.
View Article and Find Full Text PDFBMC Neurol
October 2024
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
J Clin Oncol
October 2024
Division of Radiation Oncology, Department of Oncology, McMaster University and Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton, ON, Canada.
Pharmaceutics
September 2024
Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, St. George Campus, Toronto, ON M5S 1A8, Canada.
The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint constitutes an inhibitory pathway best known for its regulation of cluster of differentiation 8 (CD8) T cell-mediated immune responses. Engagement of PD-L1 with PD-1 expressed on CD8 T cells activates downstream signaling pathways that culminate in T cell exhaustion and/or apoptosis. Physiologically, these immunosuppressive effects exist to prevent autoimmunity, but cancer cells exploit this pathway by overexpressing PD-L1 to facilitate immune escape.
View Article and Find Full Text PDFEur Urol
September 2024
Saint John Regional Hospital (MM), Saint John, New Brunswick, Canada.
Cancer Med
September 2024
Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, Quebec, Canada.
BMJ Open Gastroenterol
August 2024
Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
Objective: Gut microbes and microbe-dependent metabolites (eg, tryptophan-kynurenine-serotonin pathway metabolites) have been linked to systemic inflammation, but the microbiota-metabolite-inflammation axis remains uncharacterised in children. Here we investigated whether gut microbiota features and circulating metabolites (both microbe-dependent and non-microbe-dependent metabolites) associated with circulating inflammation markers in children.
Methods: We studied children from the prospective Gen3G birth cohort who had data on untargeted plasma metabolome (n=321 children; Metabolon platform), gut microbiota (n=147; 16S rRNA sequencing), and inflammation markers (plasminogen activator inhibitor-1 (PAI-1), monocyte chemoattractant protein-1, and tumour necrosis factor-α) measured at 5-7 years.
Genetics
October 2024
Centre Hospitalier Universitaire de Québec Research Center and Faculty of Medicine, Laval University, Québec City, QC G1V 4G2, Canada.
Hereditary tyrosinemia type 1 is an autosomal recessive disorder caused by mutations (pathogenic variants) in fumarylacetoacetate hydrolase, an enzyme involved in tyrosine degradation. Its loss results in the accumulation of toxic metabolites that mainly affect the liver and kidneys and can lead to severe liver disease and liver cancer. Tyrosinemia type 1 has a global prevalence of approximately 1 in 100,000 births but can reach up to 1 in 1,500 births in some regions of Québec, Canada.
View Article and Find Full Text PDFObesity (Silver Spring)
October 2024
Centre de Recherche du Centre hospitalier universitaire de Sherbrooke (CHUS), Sherbrooke, Québec, Canada.
Objective: This study aimed to identify whether cord blood DNA methylation at specific loci is associated with neonatal adiposity, a key risk factor for childhood obesity.
Methods: An epigenome-wide association study was conducted using the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study as a discovery sample. Linear regression models adjusted for maternal and offspring covariates and cell counts were used to analyze associations between neonatal adiposity as measured by sum of three skinfold thicknesses and cord blood DNA methylation.
FEBS J
October 2024
Ottawa Institute of Systems Biology, University of Ottawa, Canada.
Maintaining cellular homeostasis in the face of stress conditions is vital for the overall well-being of an organism. Reactive oxygen species (ROS) are among the most potent cellular stressors and can disrupt the internal redox balance, giving rise to oxidative stress. Elevated levels of ROS can severely affect biomolecules and have been associated with a range of pathophysiological conditions.
View Article and Find Full Text PDFPediatr Obes
September 2024
Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, Quebec, Canada.
Objective: This study identified metabolite modules associated with adiposity and body fat distribution in childhood using gold-standard measurements.
Methods: We used cross-sectional data from 329 children at mid-childhood (age 5.3 ± 0.
Aging Cell
August 2024
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Worldwide trends to delay childbearing have increased parental ages at birth. Older parental age may harm offspring health, but mechanisms remain unclear. Alterations in offspring DNA methylation (DNAm) patterns could play a role as aging has been associated with methylation changes in gametes of older individuals.
View Article and Find Full Text PDFAm J Cardiol
July 2024
Population Health Research Institute, Hamilton, Ontario, Canada; Hamilton Health Sciences, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:
Evidence regarding the comparative efficacy of the different methods to determine the significance of coronary stenoses in the catheterization laboratory is lacking. We aimed to compare all available methods guiding the decision to perform percutaneous coronary intervention (PCI). We searched Medline, Embase, and CENTRAL until October 5, 2023.
View Article and Find Full Text PDFEuroIntervention
May 2024
Population Health Research Institute, Hamilton, Canada.
Sci Transl Med
March 2024
Département de Pharmacologie-Physiologie, Institut de Pharmacologie de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here, we showed that defects in the endothelial cell (EC) compartment of the vascular stem cell niche in mouse models of Duchenne MD, laminin α2-related MD, and collagen VI-related myopathy were associated with inefficient mobilization of MuSCs after tissue damage. Using chemoinformatic analysis, we identified the 13-amino acid form of the peptide hormone apelin (AP-13) as a candidate for systemic stimulation of skeletal muscle ECs.
View Article and Find Full Text PDFAm J Cardiol
June 2024
Department of Medicine, Population Health Research Institute McMaster University, Hamilton, Ontario, Canada.
Our objective was to evaluate the clinical effectiveness of the SYNERGY stent (Boston Scientific Corporation, Marlborough, Massachusetts) in patients with ST-elevation myocardial infarction (STEMI). The only drug-eluting stent approved for treatment of STEMI by the Food and Drug Administration is the Taxus stent (Boston Scientific) which is no longer commercially available, so further data are needed. The CLEAR (Colchicine and spironolactone in patients with myocardial infarction) SYNERGY stent registry was embedded into a larger randomized trial of patients with STEMI (n = 7,000), comparing colchicine versus placebo and spironolactone versus placebo.
View Article and Find Full Text PDFFASEB J
March 2024
Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.
Reactive oxygen species (ROS) are among the most severe types of cellular stressors with the ability to damage essential cellular biomolecules. Excess levels of ROS are correlated with multiple pathophysiological conditions including neurodegeneration, diabetes, atherosclerosis, and cancer. Failure to regulate the severely imbalanced levels of ROS can ultimately lead to cell death, highlighting the importance of investigating the molecular mechanisms involved in the detoxification procedures that counteract the effects of these compounds in living organisms.
View Article and Find Full Text PDFJ Neuroradiol
June 2024
Department of Radiology, Radiation Oncology and Nuclear Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada. Electronic address:
Background And Purpose: To evaluate the reliability and accuracy of nonaneurysmal perimesencephalic subarachnoid hemorrhage (NAPSAH) on Noncontrast Head CT (NCCT) between numerous raters.
Materials And Methods: 45 NCCT of adult patients with SAH who also had a catheter angiography (CA) were independently evaluated by 48 diverse raters; 45 raters performed a second assessment one month later. For each case, raters were asked: 1) whether they judged the bleeding pattern to be perimesencephalic; 2) whether there was blood anterior to brainstem; 3) complete filling of the anterior interhemispheric fissure (AIF); 4) extension to the lateral part of the sylvian fissure (LSF); 5) frank intraventricular hemorrhage; 6) whether in the hypothetical presence of a negative CT angiogram they would still recommend CA.
Radiology
February 2024
From the School of Engineering, Cardiff University, Cardiff, United Kingdom (P.W., E.S.); OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany (A.Z., S.L.); National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Fetscherstrasse 74, PF 41 Dresden 01307, Germany (A.Z.); Institute of Informatics, University of Applied Sciences and Arts Western Switzerland (HES-SO), Sierre, Switzerland (V.A., R.S., H.M., A.D.); Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY (A.P.A., A.I.); Department of Computer Science, Université de Sherbrooke, Sherbrooke, QC, Canada (A.A., M.A.L.L., M.V.); Center for Artificial Intelligence and Data Science for Integrated Diagnostics (AI2D) and Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Philadelphia, Pa (B.B., S.B., S.P.); Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (B.B., S.B., S.P.); Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (B.B., S.B., S.P.); Division of Computational Pathology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Ind (B.B., S.B., S.P.); Department of Medical Physics, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy (A.B., F.M.); Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, the Netherlands (R.B.); Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy (L.B., N.D., J.L.); Institut Curie, Université PSL, Inserm U1288, Laboratoire d'Imagerie Translationnelle en Oncologie, Orsay, France (I.B., C.N., F.O.); Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom (G.J.R.C., V.G., C.G.R.); Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland (F.D., H.S.G., M.G., S.T.); Department of Radiology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom (V.G.); LaTIM, INSERM, UMR 1101, Université de Bretagne-Occidentale, Brest, France (M. Hatt, F.T.); Technological Virtual Collaboration (TECVICO Corp), Vancouver, Canada (M. Hosseinzadeh, M.R.S.); Department of Electrical and Computer Engineering, Tarbiat Modares University, Tehran, Iran (M. Hosseinzadeh); Department of Radiation Oncology, University of California San Francisco, San Francisco, Calif (O.M., T.U.); Departments of Radiology and Physics, University of British Columbia, Vancouver, Canada (A.R.); Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran (S.M.R.); Repository Unit, Cancer Research UK National Cancer Imaging Translational Accelerator, United Kingdom (C.G.R.); Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada (M.R.S., F.Y.); Department of Nuclear Medicine, Universitätsklinikum Augsburg, Augsburg, Germany (A.S.); Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland (I.S., H.Z.); Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (I.S.); Department of Diagnostic Imaging, Oncological Radiotherapy, and Hematology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy (V.V.); Department of Radiological and Hematological Sciences, Università Cattolica del Sacro Cuore-Milano, Milan, Italy (V.V.); Department of Radiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands (J.J.M.v.G.); Department of Radiology, UMC Utrecht, Utrecht, the Netherlands (J.J.M.v.G.); Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, Canada (M.V.); and Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital (CHUV), Lausanne, Switzerland (A.D.).
Filters are commonly used to enhance specific structures and patterns in images, such as vessels or peritumoral regions, to enable clinical insights beyond the visible image using radiomics. However, their lack of standardization restricts reproducibility and clinical translation of radiomics decision support tools. In this special report, teams of researchers who developed radiomics software participated in a three-phase study (September 2020 to December 2022) to establish a standardized set of filters.
View Article and Find Full Text PDFJ Biomech
January 2024
Department of Health, Kinesiology and Applied Physiology, Concordia University, Montreal, Canada. Electronic address:
It remains unclear whether paraspinal muscle fatty infiltration in low back pain (LBP) is i) solely intramuscular, ii) is lying outside the epimysium between the muscle and fascial plane (epimuscular) or iii) or combination of both, as imaging studies often use different segmentation protocols that are not thoroughly described. Epimuscular fat possibly disturbs force generation of paraspinal muscles, but is seldomly explored. This project aimed to 1) compare epimuscular fat in participants with and without chronic LBP, and 2) determine whether epimuscular fat is different across lumbar spinal levels and associated with BMI, age, sex and LBP status, duration or intensity.
View Article and Find Full Text PDF