363 results match your criteria: "Centre Hospitalier Universitaire de Dijon[Affiliation]"

Foramen tympanicum: tomographic study of a large cohort of Europeans.

Surg Radiol Anat

December 2024

Department of Plastic Reconstructive and Hand Surgery, Department of Oral and Maxillofacial Surgery, Dijon University Hospital, Boulevard de Lattre de Tassigny, 21000, Dijon, France.

Purpose: The foramen tympanicum (FT) is an anatomical variation of the tympanic part of the temporal bone located in the anteroinferior part of the external auditory pore (EAP) and posteromedial to the temporomandibular joint (TMJ). The FT is most often asymptomatic, but it can be symptomatic in rare cases. The prevalence of FT varies widely in the literature.

View Article and Find Full Text PDF

Introduction: French medical students can access occupational medicine after passing the residency examination. Few studies have looked at the lack of attractiveness of occupational medicine, contributing to the demographic decline of occupational physicians (OPs). The purpose of this study was to explore the stereotypes of OPs by their colleagues at different levels of formation to understand the determinants of the current lack of attractiveness.

View Article and Find Full Text PDF

Cerebral blood flow in attention deficit hyperactivity disorder: A systematic review.

Neuroscience

December 2024

Centre ChronoS, GHU Paris - Psychiatry & Neurosciences, Paris, France; Department of Psychiatry and Addictology, AP-HP, GHU Paris Nord, DMU Neurosciences, Bichat-Claude Bernard Hospital, Paris, France; Université Paris Cité, NeuroDiderot, Inserm, Paris, France.

Article Synopsis
  • * The review included 20 studies with a total of 2,232 participants, showing common patterns of hypoperfusion in certain brain regions during rest and hyperperfusion during cognitive tasks in those with ADHD.
  • * Key findings indicate that while certain areas like the prefrontal cortex often experience reduced blood flow at rest, other regions may show increased blood flow during tasks, suggesting the need for further research to understand these variations better.
View Article and Find Full Text PDF
Article Synopsis
  • Interstitial lung diseases (ILDs) are complex and diverse conditions that affect both children and adults, with limited treatment options and a challenging diagnosis process often requiring invasive techniques.
  • The RARE-ILD initiative is a collaborative effort by experts to develop innovative non-invasive diagnostic methods and biomarkers, leveraging artificial intelligence for improved data analysis and understanding of ILDs across different ages.
  • The eurILDreg project collects extensive patient data using various assessments and technology, with an aim to enhance research, improve patient care, and potentially revolutionize the management of ILDs for up to 4,000 patients and 100,000 biospecimens.
View Article and Find Full Text PDF
Article Synopsis
  • This study investigated the relationship between sleep apnea syndrome (SAS) and the dosage/timing of opioid substitution treatments (OST) in patients using methadone or buprenorphine for opioid use disorder.
  • It included a retrospective analysis of adult patients who received these treatments over several years, assessing their apnea-hypopnea index (AHI) alongside treatment data.
  • The findings indicated that higher doses of methadone, particularly taken in the evening, were linked to more severe SAS, while no significant association was found between buprenorphine doses and AHI, suggesting buprenorphine might be a better alternative for patients with SAS.
View Article and Find Full Text PDF

Introduction: First-line oxygenation strategy in patients with acute hypoxaemic respiratory failure consists in standard oxygen or high-flow nasal oxygen therapy. Clinical practice guidelines suggest the use of high-flow nasal oxygen rather than standard oxygen. However, findings remain contradictory with a low level of certainty.

View Article and Find Full Text PDF
Article Synopsis
  • - Cancers are the leading cause of death for people living with HIV, but there is limited nationwide data on cancer rates among this population.
  • - A study analyzed data from Estonia (2004-2021) involving 7,011 individuals with HIV, finding that HPV-associated cancers made up 21.4% of all cancer cases, with significantly higher risk ratios for both men and women living with HIV.
  • - The findings highlight the urgent need for better screening, vaccination efforts, and adherence to antiretroviral therapy to address the increased risk of HPV-related cancers among people with HIV.
View Article and Find Full Text PDF

Real-world data for marginal zone lymphoma patients in the French REALYSA cohort: The REALMA study.

Hematol Oncol

November 2024

Université Paris Cité, Assistante Publique Hôpitaux de Paris, Hôpital Saint-Louis, Service d'Hémato-Oncologie, Paris, France.

Marginal Zone Lymphoma (MZL) comprises three subtypes: extranodal MZL (EMZL), splenic MZL (SMZL) and nodal MZL (NMZL). Since clinical trials have limited representativeness, there is a need for real-world data (RWD) evidence in MZL. Real-world data in Lymphoma and survival in Adults (REALYSA) is a prospective multicentric French cohort of newly diagnosed lymphoma patients.

View Article and Find Full Text PDF

Background: Transarterial chemoembolization (TACE) is recommended as a palliative treatment for patients of the B stage of the Barcelona Clinic Liver Cancer (BCLC) classification.

Aims: To identify clinical, biological, and radiological predictors of survival in patients undergoing TACE and develop a pre-therapeutic prognostic score.

Methods: 191 adult cirrhotic patients treated for HCC with TACE at the University Hospital (UH) of Clermont-Ferrand (France) from 2007-2017 were retrospectively included.

View Article and Find Full Text PDF

Introduction: Parastomal hernias are a challenging complication of digestive ostomies. Ileal-conduit parastomal hernias after cystectomy have specific aspects. The aim of this study was to describe the incidence and natural history of ileal-conduit parastomal hernias in order to guide their management, as well as to identify risk factors to prevent them.

View Article and Find Full Text PDF

Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).

Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to compare the effectiveness of subconjunctival triamcinolone acetonide injections with intravitreal dexamethasone implants in reducing central macular thickness in patients with uveitic and postoperative macular edema.
  • An open-label, multicenter trial involved 106 adults who were randomly assigned to receive either treatment; the main measure was the change in central macular thickness after 2 months.
  • Results indicated that triamcinolone is likely as effective as dexamethasone, particularly for postoperative edema, with no significant differences in side effects, but conclusive non-inferiority was not established at the 2-month mark.
View Article and Find Full Text PDF

Antibody-mediated rejection (ABMR) remains one of the main causes of long-term graft failure after kidney transplantation, despite the development of powerful immunosuppressive therapy. A detailed understanding of the complex interaction between recipient-derived immune cells and the allograft is therefore essential. Until recently, ABMR mechanisms were thought to be solely caused by adaptive immunity, namely, by anti-human leucocyte antigen (HLA) donor-specific antibody.

View Article and Find Full Text PDF
Article Synopsis
  • Factor XI deficiency is a rare bleeding disorder, and it's hard to predict how much a person will bleed based on their Factor XI levels.
  • A study looked at pregnant women with low Factor XI levels to see how they were managed during childbirth and their experiences with pain relief methods like epidurals and spinals.
  • The results showed that a lot of women had successful pain relief procedures without complications, and it was suggested that it's safe to use these methods if Factor XI levels are above 30 IU/dL.
View Article and Find Full Text PDF
Article Synopsis
  • Advances in lymphoma treatment have made assessing health-related quality of life (HRQoL) crucial for newly diagnosed patients, yet there's limited information on their HRQoL profiles at diagnosis.
  • A study involving 3922 adults with various lymphoma types utilized three validated EORTC questionnaires to evaluate HRQoL at diagnosis, achieving high completion rates between 84% and 88%.
  • Findings highlighted significant impairments in global health status across lymphoma subtypes, with factors like gender, performance status, and B symptoms affecting HRQoL, providing valuable insights for future research and clinical practices.
View Article and Find Full Text PDF

Objectives: Avacopan, a selective C5aR1 inhibitor, recently emerged as a glucocorticoid (GCs) sparing agent in ANCA-associated vasculitis (AAV). We aim to evaluate the tolerance and efficacy of avacopan given outside randomized clinical trials or with severe kidney involvement.

Methods: In this multicentre retrospective study, we reviewed the clinical charts of patients with AAV and contraindication to high dose of GCs who received avacopan 30 mg b.

View Article and Find Full Text PDF

Development and validation of the DBS-PS (Deep Brain Stimulation-Perception Scale): Assessing parkinsonian patients' expectations to prevent post-operative disappointment?

J Neurol Sci

July 2024

Université de Lille, INSERM, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, LICEND, NS-PARK/FCRIN Network, Lille, France; CHU Lille, Neurology and Movement Disorders Department, Reference Center for Parkinson's Disease, NS-PARK/FCRIN Network, Lille, France.

Article Synopsis
  • Recent studies indicate that understanding the preoperative expectations of Parkinson's disease patients undergoing deep brain stimulation (DBS) can enhance treatment outcomes, but there are limited validated tools to measure these expectations.
  • The DBS-PS (Deep Brain Stimulation - Perception Scale) was developed as an 11-item self-administered questionnaire, divided into three domains: expectations for PD, social-life and leisure, and intimate life, and validated through exploratory factor analysis and item response theory.
  • The study showed that the DBS-PS has good reliability and validity, making it a practical tool for assessing patient expectations in clinical practice, which may help in cognitive restructuring before surgery.
View Article and Find Full Text PDF

Orbital radiotherapy for Graves' ophthalmopathy is an example of non-oncological radiotherapy. First introduced in the 1930s, this treatment has become widely used since the 1980s with several studies showing proof of both effectiveness and safety: a decrease of soft tissue involvement in 70 to 80% of patients and an improvement of ocular mobility in 30 to 80% of patients. Nowadays, it's one of the second line treatment options recognized by the European Group on Graves' orbitopathy in the management of a moderate to severe and active disease after failure of glucocorticoids.

View Article and Find Full Text PDF
Article Synopsis
  • A study was conducted across 49 ICUs in France to investigate the clinical outcomes and severity of severe Pneumocystis jirovecii pneumonia (PJP), focusing on how delayed antibiotic treatment and corticosteroid therapy affect patient survival.
  • The study included 158 patients, mainly admitted due to acute respiratory failure, and found high mortality rates (31.6% in ICU, 40.5% at 6 months), with delayed antibiotic treatment beyond 96 hours linked to a significantly higher risk of death.
  • The results indicate that most patients did not receive preventive antibiotic therapy before needing intensive care, and both delayed antibiotic treatment and the use of corticosteroids worsened mortality rates in those with severe PJP.
View Article and Find Full Text PDF

Objectives: Nontuberculous mycobacteria (NTM) bone and joint infections (BJIs) are uncommon. We evaluated the characteristics of BJIs and identified differences according to immune status.

Methods: We performed a multicenter retrospective study in France involving patients with documented NTM BJI over a 9-year period.

View Article and Find Full Text PDF

Objective: To evaluate efficacy and safety outcomes of the Xen 45 gel stent implant over 24 months of follow-up.

Methods: A retrospective analysis of prospectively collected data from the Fight Glaucoma Blindness observational registry. Complete success (CS) was defined as intraocular pressure (IOP) reduction ≥20% from preoperative and an IOP ≤18 mm Hg and ≥6 mm Hg with no secondary procedure at 2 years and without IOP-lowering medications.

View Article and Find Full Text PDF

Background: Postoperative complications, particularly respiratory complications, are of significant clinical concern in patients undergoing elective thoracic surgery. Dexamethasone (DXM), commonly administered to prevent postoperative nausea and vomiting (PONV), has potential anti-inflammatory effects that might be beneficial in reducing these complications. We aimed to investigate whether intraoperative DXM administration could mitigate the occurrence of respiratory complications following elective thoracic surgery.

View Article and Find Full Text PDF

Background: Despite improved patency with newer-generation nitinol stents, one-half of patients will require secondary interventions for in-stent restenosis (ISR). The best treatment strategy remains unclear. This study aimed to compare drug-coated balloons (DCBs) used alone or in association with excimer laser atherectomy (ELA) to simple percutaneous transluminal angioplasty (PTA) in the treatment of femoropopliteal-ISR.

View Article and Find Full Text PDF
Article Synopsis
  • ! Red blood cell transfusions can lead to fluid overload, particularly in patients with heart failure (HF) who experience acute myocardial infarction (AMI). * ! In a study involving 658 patients, those with HF had higher rates of major adverse cardiovascular events (MACE) within 30 days and 1 year, as well as new-onset HF. * ! A liberal transfusion strategy was linked to increased all-cause mortality in HF patients, with a significant number of early deaths attributed to heart failure itself, indicating that transfusion practices may need to be reconsidered in this population. * !
View Article and Find Full Text PDF

Triplet chemotherapy with or without bevacizumab as first line treatment for metastatic colorectal cancer: An AGEO multicenter real-world study.

Dig Liver Dis

September 2024

Department of Medical Oncology, Centre Léon Bérard, Lyon, France; Association des Gastro-Entérologues Oncologues (AGEO), France. Electronic address:

Background: Prior trials validated triplet chemotherapy (Tri-CT) with bevacizumab as first line treatment for metastatic colorectal cancer (mCRC) but real-world data are scarce and practices remain heterogeneous.

Aims: To evaluate Tri-CT +/- bevacizumab efficacy and safety, and to identify factors influencing treatment decisions.

Methods: The COLOTRIP retrospective study enrolled mCRC patients treated from 2014 to 2019 in 14 French centers.

View Article and Find Full Text PDF