[Prostate cancer screening : to be recommended in 2024?].

The Prostate Specific Antigen (PSA) blood test is still the only screening tool for prostate cancer. It is recommended between the ages of 50 and 69 as part of a shared decision making process between a patient and his or her doctor using a decision aid, as the test carries a significant risk of overdiagnosis. If a patient wishes to be screened, either because he is at higher risk, or because he places greater importance on a modest reduction in cancer-related mortality, the frequency of screening depends on his age, family history, and whether he is part of a high-risk group.

[Red eye : common ocular pathologies in outpatient care].

Red eye is a common condition characterized by eye redness, often accompanied by itching, burning, pain, or discharge. This condition can be caused by a multitude of factors, ranging from minor irritations to severe infections. Red eyes are a frequent complaint in outpatient practice.

[Knee pain in primary care medicine : diagnostic and therapeutic approach].

Knee pain is one of the most common musculoskeletal complaints in primary care medicine. The leading causes of knee pain are osteoarthritis and musculoskeletal disorders. A careful history and a rigorous clinical examination usually enable a diagnosis to be made without the need for further investigations.

Removal of Meropenem and Piperacillin during Experimental Hemoadsorption with the HA380 Cartridge.

Introduction: Hemoadsorption can be used as adjunctive therapy for sepsis. However, there is limited evidence regarding its antibiotic removal. In this in vivo preclinical study, we aimed to evaluate the removal of meropenem and piperacillin with the HA380 hemoadsorption cartridge.

[Mild cognitive impairment: how to find your way around as general practitioners?].

This article explores the diagnosis of Mild Cognitive Impairment (MCI) in general practice. It examines the subtypes of MCI and their specific diagnostic criteria for different neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, fronto-temporal dementia and cerebrovascular disorders. It highlights the preferential use of the Montreal Cognitive Assessment (MoCA) over the Mini-Mental State Examination (MMSE) for detecting MCI.

[The challenge of the very elderly patient in intensive care].

Patients aged 80 years and older represent a growing proportion of admissions to intensive care units (ICU) and are burdened by high mortality rates. Due to the complexity of their medical and social needs, a holistic approach is essential. Collaboration between intensivists and geriatricians could improve the overall management of older patients.

Association of mid-regional pro-adrenomedullin with office and 24-h ambulatory blood pressure in a Swiss general population sample.

Objective: Adrenomedullin (ADM) is a potent vasodilator. The association between plasma ADM levels and blood pressure (BP) remains unclear. We assessed the association between mid-regional-pro-ADM (MR-proADM) and BP in a multicenter population- and family-based cohort.

Risk Factors for Recurrence after Surgical Resection of Sinonasal Inverted Papilloma.

 Sinonasal inverted papilloma (SNIP) is a rare benign epithelial tumor of the nasal cavity and paranasal sinuses that accounts for 0.4% and 4.7% respectively, of all tumors of this anatomical region.

Monitoring equity in the delivery of health services: a Delphi process to select healthcare equity indicators.

Aims Of The Study: Health equity is a key component of quality of care and an objective for a growing number of quality improvement projects for deontological, ethical, public health and economic reasons. To monitor equity in the delivery of health services in Switzerland, there is a need to implement valid, measurable and actionable equity indicators, along with vulnerability stratifiers such as migrant status, which could lead to differences in quality of care. The aim of this study was to develop a set of healthcare equity indicators and stratifiers targeting inpatient and outpatient populations and to test their feasibility.

Neurodevelopmental outcomes of infants after in utero exposure to SARS-CoV-2 or mRNA-COVID-19 vaccine compared with unexposed infants: a COVI-PREG prospective cohort study.

Objectives: Data are lacking regarding the long-term consequences of SARS-CoV-2 and COVID-19 mRNA vaccine on infants exposed in utero. We aimed to evaluate the neurodevelopment of infants exposed prenatally to SARS-CoV-2 or mRNA-COVID-19 vaccine during pregnancy at 12 months after birth.

Methods: Infants born to mothers exposed to SARS-CoV-2 or mRNA-COVID-19 vaccine during pregnancy, or unexposed to either the virus or the vaccine were enrolled from 2021 to 2023.

Nanofat Improves Vascularization and Tissue Integration of Dermal Substitutes without Affecting Their Biocompatibility.

Dermal substitutes require sufficient tissue integration and vascularization to be successfully covered with split-thickness skin grafts. To rapidly achieve this, we provide the proof of principle for a novel vascularization strategy with high translational potential. Nanofat was generated from subcutaneous adipose tissue of green fluorescence protein (GFP) C57BL/6J donor mice and seeded onto small samples (4 mm in diameter) of the clinically approved dermal substitute Integra.

[Malignant hypercalcemia].

Malignant hypercalcemia is the main metabolic complication of cancer. Clinical presentation varies from asymptomatic to a medical emergency. The main causes include parathyroid hormone-related protein production and bone metastases, while hypervitaminosis D and hyperparathyroidism are rarer causes.

Extrafollicular CD19CXCR5CD11c double negative 3 (DN3) B cells are significantly associated with disease activity in females with systemic lupus erythematosus.

Objective: B cells play a major role in the development and maintenance of systemic lupus erythematosus (SLE). Double negative (DN) B cells defined by the lack of surface expression of IgD and CD27 have attracted recent interest for their sensitivity to Toll-like receptor 7 (TLR7) ligands and their potential role in the production of autoantibodies. Here we aimed at investigating the possible association of DN B cells and their subsets with SLE disease activity specifically in female patients, in which TLR7 gene has been reported to escape X chromosome inactivation.

Differentiating MYCN-amplified RB1 wild-type retinoblastoma from biallelic RB1 mutant retinoblastoma using MR-based radiomics: a retrospective multicenter case-control study.

MYCN-amplified RB1 wild-type (MYCNRB1) retinoblastoma is a rare and aggressive subtype, often resistant to standard therapies. Identifying unique MRI features is crucial for diagnosing this subtype, as biopsy is not recommended. This study aimed to differentiate MYCNRB1 from the most prevalent RB1 retinoblastoma using pretreatment MRI and radiomics.

[Trial of labor and gynecological uterine scars : a narrative review].

The increasing number of women of childbearing age with gynecological uterine scars presents a significant clinical challenge. -Planning the route of birth for a subsequent pregnancy necessitates -careful consideration and should be the subject of an informed -discussion. Unfortunately, the heterogeneity of data in the literature with regards to gynecological uterine scars makes this choice -debatable.

[Neonatal Fc receptor : role and implications in maternal fetal medicine].

During pregnancy, the mother's IgG immunoglobulins cross the -placenta via the neonatal Fc receptor (FcRn), enabling the fetus to acquire passive immunity. In the presence of maternal allo- or auto-antibodies, placental transfer of these pathogenic antibodies mediated by FcRn can cause diseases in the fetus and/or the newborn. FcRn blockade therefore appears to be a therapeutic strategy in these high-risk pregnancies, firstly by reducing IgG recycling, -thereby reducing its concentration in the maternal circulation, and secondly by blocking placental transfer.

[Fertility preservation in women affected by a gynecologic carcinoma].

Gynecological cancers quite often affect young women who wish to preserve their fertility. In addition, with the advancement in age of first pregnancies, this problem has currently taken on a significant scale. Most often, fertility preservation is possible provided that the cancerous tumor is discovered at an early stage and of a non-aggressive histological nature.

[Current management of advanced high grade serous ovarian carcinomas].

Ovarian cancers are gynecological cancers with a poor prognosis. Most ovarian cancers are high-grade serous carcinomas. It is now accepted that they are very often tubal in origin.