Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial.

Background: The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to cytoreductive surgery has been associated with encouraging survival results in some patients with colorectal peritoneal metastases who were eligible for complete macroscopic resection. We aimed to assess the specific benefit of adding HIPEC to cytoreductive surgery compared with receiving cytoreductive surgery alone.

Methods: We did a randomised, open-label, phase 3 trial at 17 cancer centres in France.

[Severe bacterial keratitis. A clinical, epidemiologic, and microbiologic study].

Introduction: The aim of this study was to report the epidemiologic and microbiologic features and to define the risk factors of hospitalized cases of bacterial keratitis in the Toulouse University Hospital Center of Ophthalmology (France).

Methods: This was a retrospective study including all cases of serious bacterial keratitis hospitalized between January 2006 and November 2007. Epidemiologic, microbiologic, and clinical factors such as age, reasons for hospitalization, visual loss, and risk factors were described.

Anti-IE1 CD4+ T-cell clones kill peptide-pulsed, but not human cytomegalovirus-infected, target cells.

Cellular immunity plays a major role in the control of human cytomegalovirus (HCMV) infection. CD4(+) T lymphocytes have been shown to contribute to this function but their precise role is a matter of debate. Although CD4(+) T cells have been shown to kill target cells through the perforin/granzyme pathway, whether HCMV-specific CD4(+) T cells are capable of killing HCMV-infected targets has not yet been documented.

[Seroepidemiology of toxoplasmosis in Niamey, Niger].

A seroepidemiological survey of toxoplasmosis was carried out in Niamey, Niger, in 1992. Three hundred and seventy-one sera from 200 females and 171 males were tested by indirect immunofluorescence assay for IgG. Using a cut-off value of 12 UI, 67 sera (18%) were positive.

[From heart to brain and from brain to heart: impact of an anticoagulant treatment with aspirin in secondary prevention].

Aspirin given as a platelet antiaggregant has been shown to be effective for secondary prevention both in cardiology (myocardial infarction, uncontrolled angina pectoris, coronary bypass, etc.) and in neurology (after a cerebral vascular event or an episode of temporary ischaemia). For example, the risk of non-fatal recurrence is reduced by 31% after myocardial infarction and by 22% after cerebral vascular events.

[Osteosynthesis using micro-plates in fractures of the orbital floor].

The exploration of orbital floor in case of blow-out fractures shows frequently only one or two important fragments. This fact leads us to realize osteosyntheses with titanium micro-plates in this kind of fractures. This was done for ten patients by transconjunctival approach.

Influence of the menopause and aging on spinal density in French women.

Dual photon absorptiometry (DPA) was used to measure the bone mineral density (BMD) of the lumbar spine in 510 normal women from the south of France. Long-term precision was 2.2%.