7 results match your criteria: "Centre Hospitalier Duchenne[Affiliation]"
Introduction: In 2013, rituximab was approved in France for the treatment of ANCA-associated vasculitis (AAV). The aim of the study was to compare the treatment and health events of adult incident patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), included before rituximab approval (over 2010-2012, Group 1) and those included after rituximab approval (over 2014-2017, Group 2).
Method: Data were extracted from the French National Health Insurance database (SNDS) including outpatient health care consumption and hospital discharge forms.
First-Line LV5FU2 with or without Aflibercept in Patients with Non-Resectable Metastatic Colorectal Cancer: A Randomized Phase II Trial (PRODIGE 25-FFCD-FOLFA).
Cancers (Basel)
April 2024
Department of Cancer Medicine, Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif CEDEX, France.
Fluropyrimidine monotherapy is an option for some patients with inoperable metastatic colorectal cancer. Unlike bevacizumab, the addition of aflibercept, an antibody acting as an anti-angiogenic agent, has never been evaluated in this context. The aim of the study was to determine whether aflibercept could increase the efficacy of fluoropyrimidine monotherapy without increasing toxicity.
View Article and Find Full Text PDFDigital tool to identify and monitor regorafenib-associated hand-foot skin reactions: A proof-of-concept study protocol.
Dig Liver Dis
August 2023
Gustave Roussy, Paris Saclay University, 39 Rue Camille Desmoulins, 94800 Villejuif, Paris, France.
Article Synopsis
- The FACET study is a clinical trial aimed at assessing an electronic device suite's effectiveness in detecting hand-foot skin reactions in patients with metastatic colorectal cancer who are on regorafenib treatment.
- The study involves 38 patients across six centers in France, monitored over two treatment cycles (about 56 days) with tools like connected insoles and a mobile app to gather patient feedback and educational resources.
- The trial seeks to enhance the usability of the device suite before a larger study and also discusses potential challenges in using digital tools in everyday medical practice.
Simple Aspiration versus Drainage for Complete Pneumothorax: A Randomized Noninferiority Trial.
Am J Respir Crit Care Med
June 2023
Service d'accueil des urgences.
Article Synopsis
- Management of first episodes of primary spontaneous pneumothorax (air in the chest cavity) is debated, with this study comparing simple aspiration and chest tube drainage as treatment methods.
- The trial involved 402 adults aged 18-50 and measured lung expansion 24 hours post-treatment, finding a higher failure rate in the aspiration group (29%) compared to the chest tube group (18%).
- Despite higher failure rates, the aspiration method resulted in less overall pain and fewer complications, with recurrence rates of pneumothorax being 20% for aspiration and 27% for drainage.
Epidemiology of granulomatosis with polyangiitis and microscopic polyangiitis in adults in France.
J Autoimmun
December 2022
Hôpital Cochin, Paris, France.
Background: Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are rare systemic necrotizing vasculitis. The national incidence and prevalence of GPA/MPA and patient mortality remain unknown in France. A real-life study using retrospective data from the French National Health Data System was set up to describe the epidemiology and demographic characteristics of hospitalized GPA and MPA patients, overall and by disease.
View Article and Find Full Text PDFAn unexpected cause of cardiomyopathy revealed by arrhythmias and conduction disorders in an athlete.
Int J Cardiol
December 2015
Département de Cardiologie, Pôle Cardio-vasculaire et Pulmonaire, Centre Hospitalier Régional et Universitaire de Lille, Lille, France; Faculté de Médecine, Université de Lille2, Lille, France.
[A case of primary herpetic eye disease].
J Fr Ophtalmol
May 2012
Service d'ophtalmologie, centre hospitalier Duchenne, BP 609, 62321 Boulogne-sur-Mer cedex, France.
Herpetic eye disease is very common. However, primary infections are most frequently asymptomatic. We report herein a case of a 15-year-old male whose diagnosis of primary herpetic infection was delayed and who initially had unsuitable treatment that aggravated the symptoms.
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