6 results match your criteria: "Centre Cochin University Hospital[Affiliation]"
Rapid rEcognition of COrticosteRoiD resistant or sensitive Sepsis (RECORDS): study protocol for a multicentre, placebo-controlled, biomarker-guided, adaptive Bayesian design basket trial.
BMJ Open
March 2023
General Intensive Care Unit, Hopital Raymond-Poincare, Garches, France
Article Synopsis
- The RECORDS trial investigates how different adult patients with sepsis respond to corticosteroids by categorizing them into distinct groups based on their likelihood of responding to treatment.
- It is a large, placebo-controlled study that includes 1800 adults with conditions like pneumonia and septic shock, randomly assigning them to receive either corticosteroids or placebo for 7 to 10 days.
- The primary goal is to assess the impact of corticosteroids on mortality and organ dysfunction after 90 days, with the findings expected to be shared at conferences and published in scientific journals.
Seasonal burden of severe influenza virus infection in the critically ill patients, using the Assistance Publique-Hôpitaux de Paris clinical data warehouse: a pilot study.
Ann Intensive Care
July 2021
Unité de Santé Publique, INSERM, Institut Pierre Louis d'Epidemiologie et de Sante Publique, Hopital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, 75012, Paris, France.
Article Synopsis
- The flu surveillance system in France is inconsistent across regions, highlighting the need for better data tracking during flu seasons.
- An exploratory study analyzed the impact of influenza on adult critical care patients at AP-HP during the 2017-2018 season, with findings showing low vaccination rates and high mortality among ICU patients.
- By using clinical data from electronic medical records, hospitals could improve patient management and enhance capacity for treating severe respiratory diseases, emphasizing the importance of real-time data in critical care settings.
Case Report: Takotsubo Syndrome Associated With Novel Coronavirus Disease 2019.
Front Cardiovasc Med
February 2021
Assistance Publique - Hôpitaux de Paris, Centre Cochin University Hospital, Intensive Care Medicine Department, Paris, France.
Takotsubo cardiomyopathy is triggered by emotional or physical stress. It is defined as a reversible myocardial dysfunction, usually with apical ballooning aspect due to apical akinesia associated with hyperkinetic basal left ventricular contraction. Described in cases of viral infections such as influenza, only few have been reported associated with novel coronavirus disease 2019 (COVID-19) in the recent pandemic.
View Article and Find Full Text PDFGraft Versus Host Disease Associated with Immune Checkpoint Inhibitors: A Pharmacovigilance Study and Systematic Literature Review.
Front Pharmacol
February 2021
Sorbonne Université, Clinical Investigations Center Paris-Est, AP.HP.6 Pitie-Salpetriere University Hospital, INSERM, Paris, France.
In patients with allogenic hematopoietic stem cell transplantation (allo-HSCT), immune-checkpoint inhibitors (ICI) are used to treat malignancy recurrence. However, ICI are also associated with graft vs. host disease (GVHD).
View Article and Find Full Text PDFT-piece versus pressure-support ventilation for spontaneous breathing trials before extubation in patients at high risk of reintubation: protocol for a multicentre, randomised controlled trial (TIP-EX).
BMJ Open
November 2020
Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Poitiers, Poitiers, France.
Introduction: In intensive care unit (ICU), the decision of extubation is a critical time because mortality is particularly high in case of reintubation. To reduce that risk, guidelines recommend to systematically perform a spontaneous breathing trial (SBT) before extubation in order to mimic the postextubation physiological conditions. SBT is usually performed with a T-piece disconnecting the patient from the ventilator or with low levels of pressure-support ventilation (PSV).
View Article and Find Full Text PDFSensitivity of point-of-care IgM and IgG test in critically ill patients with SARS-Cov-2.
Crit Care
September 2020
Intensive Care Medicine Department, AP.HP.Centre Cochin University Hospital, Paris, France.