30 results match your criteria: "Centre ChronoS[Affiliation]"

Pupillary response to blue light as a biomarker of seasonal pattern in Major Depressive Episode: A clinical study using pupillometry.

Psychiatry Res

December 2024

Département de psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Bichat - Claude Bernard, F-75018 Paris, France; Université Paris Cité, NeuroDiderot, Inserm, FHU I2-D2, F-75019 Paris, France; Centre ChronoS, GHU Paris - Psychiatrie & Neurosciences, 1 rue Cabanis, 75014 Paris, France; CNRS UPR 3212 & Strasbourg University, Institute for Cellular and Integrative Neurosciences, F-67000, Strasbourg, France. Electronic address:

Depressive disorders are characterized by disturbances in light signal processing. More specifically, an alteration of the melanopsin response is suggested. The post-illumination pupillary response (PIPR) to blue light (post-blue PIPR) is increasingly used as a marker of the activity of intrinsically photosensitive melanopsin ganglion cells (ipRGCs).

View Article and Find Full Text PDF

Risk of admission to hospital for self-harm after admission to hospital for COVID-19: French nationwide longitudinal study.

BJPsych Open

December 2024

Non Communicable Diseases and Trauma Division, Santé publique France, Paris, France; Department of Psychiatry, AP-HP, Louis Mourier Hospital, Paris, France; and INSERM Team 1 - UMR1266, Institute of Psychiatry and Neurosciences, Université de Paris, Paris, France.

Background: Assessing the risk of subsequent self-harm after hospitalisation for COVID-19 is critical for mental health care planning during and after the pandemic.

Aims: This study aims to compare the risk of admission to hospital for self-harm within 12 months following a COVID-19 hospitalisation during the first half of 2020, with the risk following hospitalisations for other reasons.

Method: Using the French administrative healthcare database, logistic regression models were employed to analyse data from patients admitted to hospitals in metropolitan France between January and June 2020.

View Article and Find Full Text PDF

Cerebral blood flow in attention deficit hyperactivity disorder: A systematic review.

Neuroscience

December 2024

Centre ChronoS, GHU Paris - Psychiatry & Neurosciences, Paris, France; Department of Psychiatry and Addictology, AP-HP, GHU Paris Nord, DMU Neurosciences, Bichat-Claude Bernard Hospital, Paris, France; Université Paris Cité, NeuroDiderot, Inserm, Paris, France.

Article Synopsis
  • * The review included 20 studies with a total of 2,232 participants, showing common patterns of hypoperfusion in certain brain regions during rest and hyperperfusion during cognitive tasks in those with ADHD.
  • * Key findings indicate that while certain areas like the prefrontal cortex often experience reduced blood flow at rest, other regions may show increased blood flow during tasks, suggesting the need for further research to understand these variations better.
View Article and Find Full Text PDF
Article Synopsis
  • Clozapine is effective for treatment-resistant schizophrenia but can cause significant side effects, notably excessive daytime sleepiness, which is a form of hypersomnolence.
  • A systematic review examined how clozapine affects objective measures of hypersomnolence, analyzing six studies using various testing methods like polysomnography (PSG).
  • Initial findings showed clozapine led to longer sleep times and quicker sleep onset, but these effects did not last beyond 4-6 weeks, indicating a need for further long-term research on sleep patterns and wakefulness in clozapine-treated patients.
View Article and Find Full Text PDF

Sex differences in insomnia and hypersomnia complaints during major depressive episode: Results from a national sample.

J Affect Disord

January 2025

Université Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Corentin-Celton, DMU Psychiatrie et Addictologie, Département de Psychiatrie, Issy-les-Moulineaux, France; INSERM, Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR_S1266, Paris, France.

Article Synopsis
  • The study explores sex differences in sleep disturbances during major depressive episodes (MDE), finding that a high prevalence of sleep complaints exists for both genders, but with variations in types and associations.
  • Women showed higher rates of sleep issues and specific comorbidities like histrionic personality disorder, while men were more associated with mania and substance use disorders.
  • The research highlights the importance of tailored treatment approaches for men and women based on their unique profiles, despite the limitations of the cross-sectional design which doesn't establish causality.
View Article and Find Full Text PDF
Article Synopsis
  • Parasomnias and sleep-related movement disorders (SRMD) are sleep disorders that can be triggered by certain medications, and this study aimed to review the literature on this association from January 2020 to June 2023.
  • Over 900 records were examined, identifying 73 drugs linked to common drug-induced parasomnias like nightmares and sleepwalking, as well as SRMDs such as restless legs syndrome and bruxism.
  • The study discusses potential mechanisms behind these disorders related to various neurotransmitters, including the impact of antipsychotics, opioids, and medications affecting serotonin, noradrenergic, and dopamine pathways, highlighting gaps in drug labeling for these conditions.
View Article and Find Full Text PDF

States of consciousness and interoceptive hypersensibility: A study in patients with insomnia disorder.

J Sleep Res

August 2024

Department of Psychiatry and Addiction Medicine, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Bichat-Claude Bernard, Paris, France.

This exploratory study aimed to investigate the relationship between interoceptive sensibility and quality of consciousness in individuals with insomnia disorder, in order to understand how the modulation of internal states may contribute to modifying the experience of consciousness during sleep difficulties. A total of 37 patients with insomnia disorder (mean age = 46.05 ± 18.

View Article and Find Full Text PDF

Predictive factors of cognitive impairment in alcohol use disorder inpatients.

Addict Behav

November 2024

UFR de Médecine, Université Paris Cité, 85 boulevard Saint-Germain, 75006 Paris, France; Département de psychiatrie et d'addictologie, AP-HP, DMU Neurosciences, Hôpital Bichat - Claude Bernard, APHP GHU Nord, 46 rue Henri Huchard, 75018 Paris, France; Centre ChronoS, GHU Paris - Psychiatry & Neurosciences, 1 rue Cabanis, 75014 Paris, France; CNRS UPR 3212, Institute for Cellular and Integrative Neurosciences, Strasbourg, France.

Background: Cognitive impairments are common in patients with AUD and worsen the prognosis of addiction management. There are no clear guidelines for screening cognitive impairments in hospitalized patients with AUD.

Methods: Fifty-seven patients with an AUD history who were admitted to an acute hospital and assessed by the addiction care team were included.

View Article and Find Full Text PDF

Exploring actigraphy as a digital phenotyping measure: A study on differentiating psychomotor agitation and retardation in depression.

Acta Psychiatr Scand

July 2024

Département de Psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Bichat - Claude Bernard, Paris, France.

Introduction: Psychomotor activity stands out as a crucial symptom in characterizing behaviors associated with depression. This study aims to explore the potential of actigraphy as a tool for digital phenotyping in characterizing symptoms of psychomotor agitation and retardation, which are clinically challenging dimensions to capture, in patients diagnosed with major depressive episode (MDE) according to DSM-5 criteria.

Methods: We compared rest-activity circadian rhythm biomarkers measured by the Motion Watch 8 actigraphy between 58 (78.

View Article and Find Full Text PDF

Exploring emotional regulation in insomnia with and without major depressive episode.

J Sleep Res

June 2024

Centre ChronoS, Département de psychiatrie et d'addictologie, GHU Paris Nord, DMU Neurosciences, AP-HP, Hôpital Bichat - Claude Bernard, Paris, France.

Previous studies have highlighted the pivotal role of emotional regulation impairment in the progression of depressive and insomnia disorders, individually. Nevertheless, to date, no study has undertaken a direct comparison of the emotional profiles in individuals experiencing insomnia with or without major depressive episode (MDE). In this study, our objective was to closely examine multiple aspects of emotional regulation among individuals experiencing insomnia, with or without concurrent depression.

View Article and Find Full Text PDF

Modeling longitudinal relationships between sleep disturbances and depressed mood in postpartum: A cross-lagged panel design.

J Affect Disord

October 2024

Université Paris Cité, INSERM UMR1266, Institute of Psychiatry and Neurosciences, Team 1, Paris, France; Department of Psychiatry, AP-HP, Louis Mourier Hospital, F-92700 Colombes, France.

Background: This short communication explores the interrelationships between depressed mood and sleep disturbances in one-year postpartum period.

Methods: Utilizing data from the Interaction of Gene and Environment of Depression during PostPartum Cohort (IGEDEPP) involving 3310 French postpartum women, we employed a cross-lagged panel model (CLPM) to analyze the relationships between these two symptoms, across three time points (immediate postpartum [<1 week after delivery], early postpartum [<2 months after delivery], and late postpartum [2 months to 1 years after delivery]).

Results: Depressed mood significantly influences sleep disturbances in late postpartum (β = 0.

View Article and Find Full Text PDF

Excessive daytime sleepiness (EDS) is frequent among patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and can persist despite the optimal correction of respiratory events (apnea, hypopnea and respiratory efforts), using continuous positive airway pressure (CPAP) or mandibular advancement device. Symptoms like apathy and fatigue may be mistaken for EDS. In addition, EDS has multi-factorial origin, which makes its evaluation complex.

View Article and Find Full Text PDF

Introduction: Cannabis currently stands as the most prevalent illicit substance used by adolescents in France. Its use is associated with an elevated risk of developing psychiatric disorder, affecting neuro-cognitive development, or leading to psycho-social challenges in the long run. Cognitive-behavioral therapies (CBT) have emerged as a preferred approach for treating cannabis use disorders (CUD) in adults.

View Article and Find Full Text PDF

Digital therapeutic programs are emerging almost daily, offering the potential to reduce healthcare access inequalities by providing more flexible and accessible care options. However, as with traditional healthcare, the issue of patient engagement is fundamental, and the latest research have reported that fewer than 30% of users complete these programs in their entirety. Hence, many authors emphasize the importance of studying the role of therapeutic alliances specifically adapted to digital care.

View Article and Find Full Text PDF

[Insomnia and psychiatric disorders].

Rev Prat

March 2024

Département de psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU neurosciences, hôpital Bichat-Claude-Bernard, Paris, France Centre ChronoS, GHU Paris psychiatrie et neurosciences, Paris, France Université Paris Cité, NeuroDiderot, Inserm, Paris, France.

INSOMNIA AND PSYCHIATRIC DISORDERS. Insomnia is frequent in psychiatric disorders. In particular, insomnia can be a risk factor, as well as a comorbid condition, or a symptom and an early sign of psychiatric disorders.

View Article and Find Full Text PDF

Comparative study of sleep and circadian rhythms in patients presenting unipolar or bipolar major depressive episodes.

Psychiatry Res

April 2024

Département de Psychiatrie et D'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hopital Bichat Claude Bernard, 46 rue Henri Huchard, Paris F-75018, France; Université Paris Cité, NeuroDiderot, Inserm, FHU I2-D2, Paris F-75019, France; Centre ChronoS, GHU Paris, Psychiatry & Neurosciences, 1 rue Cabanis, Paris 75014, France. Electronic address:

Currently, there is a major challenge in distinguishing between unipolar and bipolar major depressive episode. A significant body of research has been dedicated to identifying biomarkers that can aid in this differentiation due to its crucial implications, particularly for therapeutic and prognostic purposes. Among the biomarkers of interest, markers related to sleep and circadian rhythms show promise and could potentially aid in making this distinction.

View Article and Find Full Text PDF

Circadian-like patterns in electrochemical skin conductance measured from home-based devices: a retrospective study.

Front Neurol

October 2023

Département de Psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Bichat-Claude Bernard, Paris, France.

In this study, we investigated the potential of electrochemical skin conductance (ESC) measurements gathered from home-based devices to detect circadian-like patterns. We analyzed data from 43,284 individuals using the Withings Body Comp or Body Scan scales, which provide ESC measurements. Our results highlighted a circadian pattern of ESC values across different age groups and countries.

View Article and Find Full Text PDF

The nightmare severity index (NSI): A short new multidimensional tool for assessing nightmares.

J Sleep Res

May 2024

Département d'Epidémiologie, Biostatistique et Recherche Clinique AP-HP, DMU PRISME, Hôpital Bichat - Claude Bernard, Paris, France.

This psychometric pilot study aims to evaluate a new multidimensional simple scale, named the nightmare severity index (NSI) - close to the existing insomnia (ISI) and hypersomnia (HSI) severity indexes. The NSI encompasses all main dimensions of nightmare disorder, evaluating four subdimensions: frequency, emotional impact, diurnal impact, and nocturnal impact of nightmares. The NSI was completed by a total of 102 patients.

View Article and Find Full Text PDF

Predictors of cognitive behavioral therapy for insomnia (CBT-I) effects in insomnia with major depressive episode.

Psychiatry Res

November 2023

Département de Psychiatrie et D'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Bichat - Claude Bernard, Paris F-75018, France; Université Paris Cité, NeuroDiderot, Inserm, FHU I2-D2, Paris F-75019, France; Centre ChronoS, GHU Paris - Psychiatrie & Neurosciences, 1 rue Cabanis, Paris 75014, France; CNRS UPR 3212, Institute for Cellular and Integrative Neurosciences, Strasbourg F-67000, France. Electronic address:

Insomnia plays a critical role in the onset and maintenance of Major Depressive Episode (MDE). Cognitive behavioral therapy for insomnia (CBT-I) can successfully improve the sleep of patients with insomnia and MDE. Nonetheless, the factors influencing CBT-I's effects in MDE remain uncertain.

View Article and Find Full Text PDF