Synergistic anticancer activity of resveratrol with cisplatin and carboplatin in A549 lung adenocarcinoma cells.

Background: This study looked at the efficacy of combining the phytochemical resveratrol with the anticancer drugs cisplatin and carboplatin on lung adenocarcinoma cell lines.

Materials And Methods: We used MTT assay and generation of Reactive Oxygen Species levels using molecular fluorogenic probe 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA) to investigate the effects of resveratrol in combination with cisplatin and carboplatin on the proliferation and viability of cells and levels of reactive oxygen species (ROS).

Results: Resveratrol has an anti-proliferative effect on A549 lung cancer cells, inhibiting cell proliferation in a dose and time-dependent manner.

Exploring the effect of epigallocatechin gallate on non small cell lung cancer.

Introduction: Human epidemiological studies have shown that diets rich in plant polyphenols have beneficial effects on various diseases including cancer. Epigallocatechin Gallate, a flavonoid polyphenol molecule, has been shown to be both chemotherapeutic and chemo-preventive in the treatment of several forms of cancer, including lung cancer. 80% of cancers of the lungs are non-small cell lung cancers.

Realization of a green-emitting pyrosilicate-structured Er-activated YSiO phosphor: a systematic study of opto-electronic characteristics and thermal stability for lighting applications.

A series of green-emitting Y SiO:Er phosphors ( = 1-7 mol%) have been successfully synthesized using a straightforward gel-combustion method facilitated by urea. X-ray diffraction analysis provided specific patterns for samples, confirming a consistent triclinic phase across erbium-doped structures compared to undoped structures. Studies using TEM and EDX were conducted to identify the surface-related characteristics and chemical composition of the synthesized nanophosphor, respectively.

Cool green-emissive YSiO:Tb nanophosphor: auto-combustion synthesis and structural and photoluminescence characteristics with good thermal stability for lighting applications.

A cheap, versatile, sustainable and energy-efficient gel-combustion method was applied to develop a series of green-emitting down-converted YSiO:Tb (YPS:Tb) nanophosphors. Employing XRD-based Rietveld refinement approach, the phase purity and crystallographic evaluation of the produced phosphor were conducted, revealing a triclinic crystal with 1̄ space group. EDX and TEM analyses were performed on the synthesized samples to determine their elemental composition and morphological properties.

Developments in conducting polymer-, metal oxide-, and carbon nanotube-based composite electrode materials for supercapacitors: a review.

Supercapacitors are the latest development in the field of energy storage devices (ESDs). A lot of research has been done in the last few decades to increase the performance of supercapacitors. The electrodes of supercapacitors are modified by composite materials based on conducting polymers, metal oxide nanoparticles, metal-organic frameworks, covalent organic frameworks, MXenes, chalcogenides, carbon nanotubes (CNTs), In comparison to rechargeable batteries, supercapacitors have advantages such as quick charging and high power density.

Folate conjugated albumin as a targeted nanocarrier for the delivery of fisetin: and biological studies.

Fisetin (FST), a natural flavonoid compound derived from various fruits and vegetables, including apple, strawberry, and onion, demonstrates potential for a wide range of pharmaceutical applications, including potential anticancer properties. However, challenges such as low bioavailability, poor aqueous solubility, and limited permeability restrict the use of FST in the pharmaceutical sector. Nowadays, targeted nanomedicines have garnered attention to overcome limitations associated with phytochemicals, including FST.

A Comprehensive Review of the Diverse Spectrum Activity of 1,2,3-Triazole-linked Isatin Hybrids.

Heterocyclic compounds containing 1,2,3-triazole and isatin as core structures have emerged as promising drug candidates due to their diverse biological activities such as anti-cancer, antifungal, antimicrobial, antitumor, anti-epileptic, antiviral, and more. The presence of 1,2,3-triazoles and isatin heterocycles in these hybrids, both individually known for their medicinal significance, has increasingly piqued the interest of drug discovery researchers, as they seek to delve deeper into their extensive pharmacological potential for enhancing therapeutic efficacy. Moreover, these hybrid compounds are synthetically accessible using readily available materials.

A green light emissive LaSrAlO:Er nanocrystalline material for solid state lighting: crystal phase refinement and down-conversion photoluminescence with high thermal stability.

The present study reveals the structural and optoelectronic characteristics of a down-converted (DC) green luminous Er doped LaSrAlO phosphor that was produced by employing an efficient and reliable gel-combustion process assisted with urea as a fuel. Using Rietveld refinement of diffraction data, the crystal structure and phase formation were examined. The surface morphology and elemental configuration of the phosphor were analyzed TEM and EDX spectroscopy, respectively.

Unlocking therapeutic potential: integration of drug repurposing and immunotherapy for various disease targeting.

Drug repurposing, also known as drug repositioning, entails the application of pre-approved or formerly assessed drugs having potentially functional therapeutic amalgams for curing various disorders or disease conditions distinctive from their original remedial indication. It has surfaced as a substitute for the development of drugs for treating cancer, cardiovascular diseases, neurodegenerative disorders, and various infectious diseases like Covid-19. Although the earlier lines of findings in this area were serendipitous, recent advancements are based on patient centered approaches following systematic, translational, drug targeting practices that explore pathophysiological ailment mechanisms.

How to identify a smoker: a salient crystallographic approach to detect thiocyanate content.

There is an increasing demand for monitoring environmental pollutants and the control requires new sensing materials with better sensitivity, selectivity and reliability. In this study, a series of Co clusters incorporating various flexible polyhydroxyamine ligands are explored, with the first report of thiocyanate recognition triggered by crystal formation using a Co crystal (1). For this, we have fortunately synthesized three new mixed metal Co clusters with fascinating structural features.