Curcumin Encapsulated into Biocompatible Co-Polymer PLGA Nanoparticle Enhanced Anti-Gastric Cancer and Anti-Helicobacter Pylori Effect.

Background: The current disadvantages (high cost, toxicity, resistance) of chemotherapy for gastric cancer opted people for alternative therapy from natural source. Curcumin (natural product) possess multiple biological activities but low bio-availability limits their uses as therapeutic. The Nano-formulation of curcumin increased the bioavailability and productivity of anti-cancer and anti-bacterial properties.

Bioavailability and risk assessment of trace metals in sediments of a high-altitude eutrophic lake, Ooty, Tamil Nadu, India.

Ooty lake, in the southern part of India, has raised huge concern about the role of metals in a lake due to increasing anthropogenic activities. Present study is aimed at understanding fate of trace metals in a lake's sediment. Sixteen sediment samples collected from bottom of the lake at various locations during March 2017 were analysed for trace metals cobalt, chromium, copper, iron, lead, manganese, nickel and zinc.

Deciphering foot-and-mouth disease (FMD) virus-host tropism.

The pattern of interactions between foot and mouth disease (FMD) viral protein 1 (VP1) with susceptible and resistant host integrins were deciphered. The putative effect of site-directed mutation on alteration of interaction is illustrated using predicted and validated 3D structures of VP1, mutated VP1 and integrins of , and . Strong interactions were observed between FMDV-VP1 protein motifs at conserved tripeptide, Arg-Gly-Asp RGD and at domain SIPLQ in alpha-integrin of Notably, site-directed mutation in FMDV-VP1 protein led to complete loss of interaction between FMD-VP1 protein and integrin, which confirmed the active role of arginine-glycine-aspartic acid (RGD) domain.

The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis.

NF-κB is a transcription factor involved in the regulation of multiple physiological and pathological cellular processes, including inflammation, cell survival, proliferation, and cancer cell metastasis. NF-κB is frequently hyperactivated in several cancers, including triple-negative breast cancer. Here we show that NF-κB activation in breast cancer cells depends on the presence of the CHORDC1 gene product Morgana, a previously unknown component of the IKK complex and essential for IκBα substrate recognition.

Biomass burning in Indo-China peninsula and its impacts on regional air quality and global climate change-a review.

Although, many biomass burning (BB) emissions products (particulate matter and trace gases) are believed to be trans-boundary pollutants that originates from India and China (the two most populous countries in Asia), the information about BB emission and related contents is limited for Indo-China Peninsula (ICP) region. This motivated us to review this region pertaining to BB emission. The main objective of the review is to document the current status of BB emission in ICP region.

An insight into the photophysical properties of amide hydrogen bonded N-(benzo[d]thiazol-2-yl) acetamide crystals.

Three distinct, hydrogen bond associated N-(benzo[d]thiazol-2-yl) acetamides were synthesized by refluxing benzothiazoles with acetic acid. The nature of the assemblies was characteristic to the substituent in the benzothiazole moiety. In N-(benzo[d]thiazol-2-yl)acetamide, water acts as a bridge for forming three hydrogen bonds, as an acceptor to amide NH, and donors to carbonyl of amide and thiazole nitrogen assembles of three different N-(benzo[d]thiazol-2-yl)acetamide molecules.

Transcript Quantification of Genes Involved in Steviol Glycoside Biosynthesis in Stevia rebaudiana Bertoni by Real-Time Polymerase Chain Reaction (RT-PCR).

Stevia (Stevia rebaudiana Bertoni) is a medicinal plant having sweet, diterpenoid glycosides known as steviol glycosides which are 200-300 times sweeter than sucrose (0.4 % solution). They are synthesized mainly in the leaves via plastid localized 2-C-methyl-D-erythrose-4-phosphate pathway (MEP pathway).

Micropropagation and Biomass Production of True-to-Type Stevia rebaudiana Bertoni.

Here we describe an efficient micropropagation protocol for Stevia rebaudiana Bertoni. We present experiments carried out to optimize the suitable media for in vitro shoot multiplication and root induction and to study the effect of culture vessel on shoot multiplication. Among all different media tested for in vitro shoot multiplication, hormone-free liquid medium is most suitable.

Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes.

Establishing c-Myc's (Myc) role in liver regeneration has proven difficult particularly since the traditional model of partial hepatectomy may provoke an insufficiently demanding proliferative stress. We used a model of hereditary tyrosinemia whereby the affected parenchyma can be gradually replaced by transplanted hepatocytes, which replicate 50-100-fold, over several months. Prior to transplantation, livers from myc-/- (KO) mice were smaller in young animals and larger in older animals relative to myc+/+ (WT) counterparts.

Water-soluble, luminescent ZnTe quantum dots: supersaturation-controlled synthesis and self-assembly into nanoballs, nanonecklaces and nanowires.

A supersaturation-controlled aqueous synthesis route has been developed for ZnTe quantum dots (QDs) with high monodispersity, size tunability, stability, band-edge luminescence (full-width at half-maximum (FWHM) 10-12 nm) and negligibly small Stokes' shift (2-4 nm). The degree of supersaturation of the initial reaction mixture was varied by increasing the reagent concentration, but keeping the molar ratio Zn(2+) : thioglycolic acid : Te(2-) constant at 1 : 2.5 : 0.

Biological mosquito control is affected by alternative prey.

Background: Mosquitofish were introduced to several countries of the tropics and subtropics as biological agents for the control of mosquito larvae. Meanwhile, they became a threat to native communities and fish worldwide, similar to other invasive species through resource competition, overexploitation, or habitat alteration. We investigated prey selectivity patterns of (mosquitofish) preying on larvae of the two Indian major carps ( and ) in the presence of varied proportions of alternative prey (rotifers, cladocerans, chironomid and mosquito larvae) under laboratory conditions.

Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities.

On the basis of the potent inhibitory activity of neplanocin A (1) against S-adenosylhomocysteine (AdoHcy) hydrolase, we analyzed the comprehensive structure-activity relationships by modifying the adenine and carbasugar moiety of 1 to find the pharmacophore in the active site of the enzyme. The introduction of 7-deazaadenine instead of adenine eliminated the inhibitory activity against the AdoHcy hydrolase, while 3-deazaadenine maintained the inhibitory activity of the enzyme, indicating that N-7 is essential for its role as a hydrogen bonding acceptor. The substitution of hydrogen at the 6'-position with fluorine increased the inhibitory activity of the enzyme.

Current status of persistent organic pesticides residues in air, water, and soil, and their possible effect on neighboring countries: a comprehensive review of India.

Though the use of pesticides has offered significant economic benefits by enhancing the production and yield of food and fibers and the prevention of vector-borne diseases, evidence suggests that their use has adversely affected the health of human populations and the environment. Pesticides have been widely distributed and their traces can be detected in all areas of the environment (air, water and soil). Despite the ban of DDT and HCH in India, they are still in use, both in domestic and agricultural settings.

Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke.

Stroke is a severe neurological disorder characterized by the abrupt loss of blood circulation into the brain resulting into wide ranging brain and behavior abnormalities. The present study was designed to evaluate molecular mechanism by which sesamin (SES) induces neuroprotection in mouse model of ischemic stroke. The results of this study demonstrate that SES treatment (30 mg/kg bwt) significantly reduced infarction volume, lipid per-oxidation, cleaved-caspase-3 activation, and increased GSH activity following MCAO in adult male mouse.

Chimeric murine interferon regulatory factor-2 (IRF-2) binds to IRF-E (IRF binding element), VREβ (virus response element) but not to VREα1.

Interferon regulatory factor-2 (IRF-2) is a multifunctional transcription factor having gene activation, repression and synergistic effect in conjunction with IRF-1. IRF-2 is also involved in type I IFN signalling by repressing INFβ gene. So far, the molecular mechanism of its DNA binding activity remains elusive.

Treatment of wastewater and restoration of aquatic systems through an eco-technology based constructed treatment wetlands - a successful experience in Central India.

In the last couple of decades constructed wetlands (CWs) have drawn considerable interest in Central India. CWs offer an effective means of integrating wastewater treatment and resource enhancement, often at competitive cost in comparison to conventional wastewater treatments, with additional benefits of Green Urban Landscaping and wildlife habitat. This paper describes treatment performances and the design of some Sub Surface Flow CWs (SSFCW) and Artificial Floating Islands (AFIs) in Central India.

L-glutamine and L-glutamic acid facilitate successful agrobacterium infection of recalcitrant tea cultivars.

The first step in Agrobacterium tumefaciens infection of plants is the establishment of cell-cell contact between the two partners. However, failure to establish such contact makes many plants and explants recalcitrant to A. tumefaciens infection.

Trace metal fractionation in the Pichavaram mangrove-estuarine sediments in southeast India after the tsunami of 2004.

The geochemistry of coastal sediments of southern India was altered after the tsunami in 2004. A five-step sequential extraction procedure was applied to assess the effects of tsunami on mobility and redistribution of selected elements (Cd, Cr, Cu, Fe, Mn, Ni, Pb, and Zn). Ten surface sediments and three cores were analyzed for different metal fractions (exchangeable, carbonate, reduced, oxidized, and residual).

In vitro plant propagation of Catharanthus roseus and assessment of genetic fidelity of micropropagated plants by RAPD marker assay.

An investigation was carried out to develop an efficient micropropagation protocol for Catharanthus roseus. Experiments were conducted to optimize suitable media for in vitro shoot multiplication and root induction. Out of the different media compared for in vitro shoot multiplication, Murashige and Skoog (MS) medium supplemented with 1 mg/l of 6-benzylaminopurine and 0.