Antidiabetic and hypolipidemic activities of eburicoic acid, a triterpenoid compound from , by regulation of Akt phosphorylation, gluconeogenesis, and PPARα in streptozotocin-induced diabetic mice.

The study is designed to examine the potential effects and underlying mechanisms of eburicoic acid (TRR), a compound from , in streptozotocin (STZ)-induced diabetic mice. Diabetic mice were randomly divided into six groups and given TRR orally by gavage (at three dosage rates) or fenofibrate (Feno) (250 mg kg body weight) or metformin (Metf) (300 mg kg body weight) or vehicle for 2 weeks. STZ-induced diabetic mice were found to have increased blood glucose, HbA1, plasma triglyceride (TG) and total cholesterol (TC) levels, but reduced blood insulin, adiponectin, and leptin levels as compared with the CON group.