Investigation of the detoxification effect of on -induced acute toxicity in rats using a HPLC-Q-TOF/MS-based metabolomics approach.

, a traditional Chinese medicine (TCM), has been widely used to treat paraplegia, facial nerve palsy and myasthenia gravis. However, its clinical application is greatly limited due to its fatal toxicity. To investigate the acute toxicity of and the detoxification effect of , a high-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF/MS) based urinary metabolomics method was developed in this study.