977 results match your criteria: "Central South University Changsha[Affiliation]"

Since NaV(PO) (NVP) possesses modest volume deformation and three-dimensional ion diffusion channels, it is a potential sodium-ion battery cathode material that has been extensively researched. Nonetheless, NVP still endures the consequences of poor electronic conductivity and low voltage platforms, which need to be further improved. On this basis, a high voltage platform NaV(PO)F was introduced to form a composite with NVP to increase the energy density.

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Half-calcined dolomites (HCDs) have been widely used in environmental remediation, medicine, and construction. However, advanced calcination technologies are required to modify their microstructure and thus improve their working performance. Herein, we investigated the effects of a variety of inorganic salts on the decomposition of dolomite based on thermogravimetric, compositional, and morphological analysis.

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Autophagy, a highly regulated lysosome-dependent catabolic pathway, has garnered increasing attention because of its role in leukemia resistance. Among the S100 family of small calcium-binding proteins, S100P is differentially expressed in various tumor cell lines, thereby influencing tumor occurrence, invasion, metastasis, and drug resistance. However, the relationship between S100P and autophagy in determining chemosensitivity in leukemia cells remains unexplored.

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Background: Increasing evidence suggests a higher propensity for acute myocardial infarction (MI) in patients with psoriasis. However, the shared mechanisms underlying this comorbidity in these patients remain unclear. This study aimed to explore the shared genetic features of psoriasis and MI and to identify potential biomarkers indicating their coexistence.

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Unleashing the high energy potential of zinc-iodide batteries: high-loaded thick electrodes designed with zinc iodide as the cathode.

Chem Sci

March 2024

Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University Hefei Anhui 230601 China

The realization of high energy is of great importance to unlock the practical potential of zinc-iodine batteries. However, significant challenges, such as low iodine loading (mostly less than 50 wt%), restricted iodine reutilization, and severe structural pulverization during cycling, compromise its intrinsic features. This study introduces an optimized, fully zincified zinc iodide loaded onto a hierarchical carbon scaffold with high active component loading and content (82 wt%) to prepare a thick cathode for enabling high-energy Zn-I batteries.

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Cancer is a major cause of death globally, and traditional treatments often have limited efficacy and adverse effects. Immunotherapy has shown promise in various malignancies but is less effective in tumors with low immunogenicity or immunosuppressive microenvironment, especially sarcomas. Tertiary lymphoid structures (TLSs) have been associated with a favorable response to immunotherapy and improved survival in cancer patients.

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Since the successful separation of graphene, carbon materials with the excellent physical and chemical properties have attracted the interest of a large number of researchers. In this paper, density functional theory combined with non-equilibrium Green's function is used to systematically study the electronic structures of two-dimensional biphenylene, net-graphene, graphene+ and T-graphene, and to reveal the electron transport properties of net-graphene nanodevices under asymmetric regulation. The results show that biphenylene, net-graphene, graphene+, and T-graphene all show metallic properties, in which biphenylene and net-graphene show anisotropy, while graphene+ and T-graphene show isotropy.

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Objectives: Uterine adhesion is mainly caused by endometrial injury, leading to poor postoperative pregnancy outcome. Therefore, preoperative evaluation on uterine cavity, especially endometrial condition, is very necessary. This study aims to explore the correlation between preoperative three-dimensional transvaginal ultrasound (3D-TVS) imaging characteristics and postoperative pregnancy outcomes after hysteroscopic adhesiolysis (HA).

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The proton exchange membrane fuel cell (PEMFC) is an efficient and clean energy source with promising applications. However, drawbacks such as high cost and low durability limit its application. Bipolar plates are an important component of PEMFCs, which not only account for a large proportion of the price and quality, but also affect the performance and durability of PEMFCs.

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Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine.

Adv Sci (Weinh)

April 2024

Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China.

Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat diseases related to central nervous system (CNS) damage. However, the blood-brain barrier (BBB) constitutes a significant impediment to the effective delivery of TCM, thus substantially diminishing its efficacy. Advances in nanotechnology and its applications in TCM (also known as nano-TCM) can deliver active ingredients or components of TCM across the BBB to the targeted brain region.

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The global prevalence of obesity has reached epidemic levels, significantly elevating the susceptibility to various cardiometabolic conditions and certain types of cancer. In addition to causing metabolic abnormalities such as insulin resistance (IR), elevated blood glucose and lipids, and ectopic fat deposition, obesity can also damage pancreatic islet cells, endothelial cells, and cardiomyocytes through chronic inflammation, and even promote the development of a microenvironment conducive to cancer initiation. Improper dietary habits and lack of physical exercise are important behavioral factors that increase the risk of obesity, which can affect gene expression through epigenetic modifications.

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The electrochemical CO reduction reaction (CORR) triggered by renewable electricity provides a promising route to produce chemical feedstocks and fuels with low-carbon footprints. The intrinsic challenge for the current CORR electrolyzer is the carbonate issue arising from the reaction between hydroxide and CO. Acid CORR electrolyzers, in principle, can effectively solve the carbonate formation, but it remains inevitable practically.

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Both the epigenetic changes and gut microbiota (GM) have attracted a growing interest in establishing effective diagnostics and potential therapeutic strategies for a number of diseases. These disorders include metabolic, central nervous system-related diseases, autoimmune, and gastrointestinal infections (GI). Despite the number of studies, there is no extensive review that connects the epigenetics modifications and GM as biomarkers that could confer effective diagnostics and confer treatment options.

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Adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) are two consecutive pathological processes that occur before invasive lung adenocarcinoma (LUAD). However, our understanding of the immune editing patterns during the progression of LUAD remains limited. Furthermore, we know very little about whether alterations in driver genes are involved in forming the tumor microenvironment (TME).

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In the past few decades, great efforts have been made to develop advanced transition metal dichalcogenide (TMD) materials as metal-ion battery electrodes. However, due to existing conversion reactions, they still suffer from structural aggregation and restacking, unsatisfactory cycling reversibility, and limited ion storage dynamics during electrochemical cycling. To address these issues, extensive research has focused on molecular modulation strategies to optimize the physical and chemical properties of TMDs, including phase engineering, defect engineering, interlayer spacing expansion, heteroatom doping, alloy engineering, and bond modulation.

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Plant phenotypic characteristics, especially leaf morphology of leaves, are an important indicator for species identification. However, leaf shape can be extraordinarily complex in some species, such as oaks. The great variation in leaf morphology and difficulty of species identification in oaks have attracted the attention of scientists since Charles Darwin.

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In this study, thermodynamic analysis is implemented to the kerosene-fuelled high by-pass turbofan (HBP-TF) engine to assess entropy, exergy, environmental, and sustainability metrics for different design variables such as pressure ratio of high-pressure compressor (HPC-PR) ranging from 7.5 to 8.5 and turbine inlet temperature (TIT) varying from 1400 to 1525 K considering variable needs in the aviation industry.

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The discovery of the endothelium as a major regulator of vascular tone triggered intense research among basic and clinical investigators to unravel the physiologic and pathophysiologic significance of this phenomenon. Sphingosine-l-phosphate (S1P), derived from the vascular endothelium, is a significant regulator of blood pressure. However, the mechanisms underlying the regulation of S1P biosynthetic pathways in arteries remain to be further clarified.

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Erratum: HOXC10 promotes carboplatin resistance of ovarian cancer by regulating ABCC3.

Am J Cancer Res

January 2024

Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University Changsha, Hunan, China.

[This corrects the article on p. 4602 in vol. 12, PMID: 36381312.

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ZW10 interacting kinetochore protein (ZWINT), an essential part of the kinetochore complex, plays a crucial role in maintaining genome stability by correcting improper attachments between the kinetochore and microtubules. An initial analysis of The Cancer Genome Atlas and Gene Expression Omnibus databases revealed that ZWINT is significantly expressed across a diverse range of tumor types. We subsequently investigated the influence of ZWINT on clinical outcomes and potential signaling pathways.

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Background: The effectiveness of critical care ultrasound has been demonstrated and training for it is urgent. Critical Care Ultrasound Study Group (CCUSG) has been dedicated to ultrasound training. The aim of the study was to evaluate course structure and training effect and provide improvement suggestions for future training.

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Article Synopsis
  • Mushroom poisoning poses a significant public health threat, but currently, there is no specific antidote, prompting research into Ganoderma lucidum as a potential treatment option.
  • A retrospective study over 20 years involving 556 mushroom poisoning cases found that administering Ganoderma lucidum reduced mortality rates from 35% to 0% and improved liver function within 10 days.
  • The study identified Ganoderic acid A, a key component of Ganoderma lucidum, as effective in enhancing survival rates and liver function by inhibiting the JAK2-STAT3 pathway, suggesting it plays a crucial role in detoxification.
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Correction to: Increased RTN3 phenocopies nonalcoholic fatty liver disease by inhibiting the AMPK-IDH2 pathway.

MedComm (2020)

February 2024

Department of Nephrology National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University Changsha China.

[This corrects the article DOI: 10.1002/mco2.226.

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Article Synopsis
  • Marfan syndrome (MFS) is a genetic disorder linked to the FBN1 gene, impacting the skeletal, cardiopulmonary, and ocular systems, prompting research into how epigenetics influences the variability of symptoms in the disease.
  • Using the Illumina 850K DNA methylation array, researchers examined blood samples from patients with MFS and healthy individuals, identifying 1253 differentially methylated positions (DMPs) associated primarily with conditions like scoliosis and cardiomyopathy.
  • The findings suggest a crucial link between DNA methylation changes and clinical features in MFS, potentially leading to insights about why untreated patients experience severe symptoms and reduced lifespan.
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Lithium-ion batteries with lithium cobalt oxide (LiCoO) as a cathode and graphite as an anode are promising energy storage systems. However, the high-temperature storage mechanism under different states of charge (SOCs) conditions in batteries remains inadequately elucidated, and a clear storage policy has yet to be established. This study investigates and compares the capacity decay mechanism of a 63 mA h LiCoO/graphite battery at 45 °C under various SOCs (100%, 75%, 50%, 30%, 0%), while also analysing the underlying reasons for this decay.

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