MDK induces temozolomide resistance in glioblastoma by promoting cancer stem-like properties.

Glioblastoma (GBM) is the most frequently observed and aggressive type of high-grade malignant glioma. Temozolomide (TMZ) is the primary agent for GBM treatment. However, TMZ resistance remains a major challenge.

HOXC10 promotes carboplatin resistance of ovarian cancer by regulating ABCC3.

HOXC10 has been reported to be upregulated in ovarian cancer (OC) tissues, attributing to the metastasis of OC. However, the specific functions of HOXC10 in OC, especially its role in chemoresistance, remain to be determined. Therefore, in this study, we explored the function and the underlying mechanisms of HOXC10 in carboplatin resistance of OC.

A smelting-rolling strategy for ZnIn bulk phase alloy anodes.

Reversibility and stability are considered as the key indicators for Zn metal anodes in aqueous Zn-ion batteries, yet they are severely hindered by uncontrolled Zn stripping/plating and side reactions. Herein, we fabricate a bulk phase ZnIn alloy anode containing trace indium by a typical smelting-rolling process. A uniformly dispersed bulk phase of the whole Zn anode is constructed rather than only a protective layer on the surface.

Dearomative -diprenylation of hydroxynaphthalenes by an engineered fungal prenyltransferase.

Prenylation usually improves structural diversity and bioactivity in natural products. Unlike the discovered enzymatic -diprenylation of mono- and tri-cyclic aromatic systems, the enzymatic approach for -diprenylation of bi-cyclic hydroxynaphthalenes is new to science. Here we report an enzymatic example for dearomative C4 -diprenylation of α-hydroxynaphthalenes, by the F253G mutant of a fungal prenyltransferase CdpC3PT.

Associations of Hypertriglyceridemia Onset Age With Cardiovascular Disease and All-Cause Mortality in Adults: A Cohort Study.

Background Limited studies have involved new-onset hypertriglyceridemia, and this study was to evaluate the associations of hypertriglyceridemia onset age with cardiovascular diseases (CVD) and all-cause mortality. Methods and Results This population-based prospective study enrolled 98 779 participants free of hypertriglyceridemia and CVD at baseline in the Kailuan study initiated in June 2006. All participants underwent health checkups biennially until December 2017, and a total of 13 832 participants developed new hypertriglyceridemia.

Knowledge base and emerging trends in YAP1 research.

Yes-associated protein 1 (YAP1) is a transcriptional coactivator that mediates the Hippo signaling pathway, which participates in the development and growth of the body; it plays key roles in tumorigenesis, metastasis, and therapy resistance. However, the pathophysiological mechanism of YAP1 has not been fully elucidated. Therefore, we explored the status and evolutionary trend in YAP1 research via bibliometric analysis.

Efficacy of non-surgical periodontal treatment on patients with coronary artery disease: a meta-analysis of randomized controlled trials.

Background: Coronary artery disease (CAD) is defined as one of the most common cardiovascular diseases (CVDs). Periodontitis is one of the risk factors for CAD.

Material And Methods: PubMed, Embase and Cochrane Library databases were carefully and thoroughly retrieved until October 2021.

FOXP1 and FOXO3a Are Prognostic Markers in Gallbladder Squamous Cell/Adenosquamous Carcinomas and Adenocarcinomas.

The pathologic characteristics of squamous cell/adenosquamous carcinomas (SC/ASC) have not been well clarified. As a rare subtype of gallbladder cancer (GBC), no biological markers for diagnosis and prognosis are available. This research evaluated the expression of FOXP1 and FOXO3a in 69 SC/ASC, and 146 adenocarcinoma (AC) samples were analyzed via immunohistochemistry.

High expression of SMARCC1 predicts poor prognosis in gastric cancer patients.

The switching/sucrose non-fermenting (SWI/SNF) chromatin remodeling complexes use the energy of ATP hydrolysis to remodel nucleosomes and modulate transcription, which plays an important role in tumors by regulating epigenetics. SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 1 (SMARCC1) has dual roles in tumors but its role in gastric cancer remains unclear. This study was aimed to find the role of SMARCC1 in gastric cancer.

Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease.

Background: Crohn's disease (CD) is a chronic inflammatory disorder characterized by intestinal immune dysfunction. Multiple factors, including gut dysbiosis, are involved in the pathogenesis of CD. However, the effect of commensal bacteria on controlling the inflammatory response in individuals with CD remains unclear.

Trimethylamine N-Oxide Generated by the Gut Microbiota: Potential Atherosclerosis Treatment Strategies.

Cardiovascular diseases (CVD) have become a disease burden that plagues the world, and a large proportion of the world's mortality currently stems from atherosclerotic CVD. In addition to traditional therapies, we need to find more therapeutic targets and strategies in scientific research to address this challenge. In recent years, as research on gut microbiota has continued, there has been a clearer understanding of the role that metabolites from gut microbes play during atherosclerosis (AS).

TXNIP inhibits the progression of osteosarcoma through DDIT4-mediated mTORC1 suppression.

Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents and children. The pathogenesis of this disease is complex and the mechanisms involved have not been fully elucidated. Thioredoxin-interacting protein (TXNIP), as a member of the α-rhodopsin inhibitory protein family, can combine with thioredoxin to inhibit its antioxidant function.

Climate warming restructures seasonal dynamics of grassland soil microbial communities.

Soil microbial community's responses to climate warming alter the global carbon cycle. In temperate ecosystems, soil microbial communities function along seasonal cycles. However, little is known about how the responses of soil microbial communities to warming vary when the season changes.

Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer.

Ivermectin is a widely used antiparasitic drug and shows promising anticancer activity in various cancer types. Although multiple signaling pathways modulated by ivermectin have been identified in tumor cells, few studies have focused on the exact target of ivermectin. Herein, we report the pharmacological effects and targets of ivermectin in prostate cancer.

Shift Work and the Risk of Cardiometabolic Multimorbidity Among Patients With Hypertension: A Prospective Cohort Study of UK Biobank.

Background Although the association between shift work and individual cardiometabolic diseases has been well studied, its role in the progression to cardiometabolic multimorbidity (CMM) remains unclear. In this study, we investigate the association between shift work and the incidence of CMM in patients with hypertension. Methods and Results This study is a population-based and prospective cohort study on 36 939 UK Biobank participants.

Cell-free fat extract protects septic lethality via restraining NLRP3 inflammasome activation.

Background: Sepsis is a dysregulated host response to infection with high mortality and current management cannot reach optimal remission. Previous studies have shown that cell-free fat extract (CEFFE) is a kind of bioactive extraction from adipose tissues and exhibits a potent anti-inflammatory effect on wound healing and inflammatory diseases. However, the potential role of CEFFE in sepsis remains unclear.

Serum sphingosine-1 phosphate level is increased in patients with hepatitis B and displays a positive association with liver fibrosis.

Objective: To investigate the difference in serum sphingosine-1 phosphate (S1P) concentration between the HBV hepatitis patients and healthy controls, and its relevant association with serum liver fibrosis indicators.

Methods: A total of 28 HBsAg (+) HBeAg (+) Anti-HBc (+) hepatitis B patients, 42 HBsAg (+) Anti-HBe (+) Anti-HBc (+) hepatitis B patients, and 21 healthy subjects with normal liver function were included. Liquid chromatography-tandem mass method was used to detect the level of serum S1P.

An inflammatory response-related gene signature associated with immune status and prognosis of acute myeloid leukemia.

Objective: To determine the prognostic significance of inflammatory response-associated genes in acute myeloid leukemia (AML).

Methods: Transcriptomic profiles and related clinical information of AML patients were acquired from a public database. To establish a multi-gene prognosis signature, we performed least absolute shrinkage and selection operator Cox analysis for the TCGA cohort and evaluated the ICGC cohort for verification.

MiR-222 regulates the progression of oral squamous cell carcinoma by targeting CDKN1B.

Objective: The purpose of this study was to establish a causal relationship between microRNA (miR-222) and oral squamous cell carcinoma (OSCC).

Methods: The cell viability of each treatment group was measured by MTT. The effects of miR-222 on cell metastasis and apoptosis were measured by transwell and flow cytometry.

Detection of COVID-19 from chest X-ray images: Boosting the performance with convolutional neural network and transfer learning.

Coronavirus disease (COVID-19) is a pandemic that has caused thousands of casualties and impacts all over the world. Most countries are facing a shortage of COVID-19 test kits in hospitals due to the daily increase in the number of cases. Early detection of COVID-19 can protect people from severe infection.

Early-like differentiation status of systemic PD-1CD8 T cells predicts PD-1 blockade outcome in non-small cell lung cancer.

Objectives: Despite remarkable advances in the treatment of non-small cell lung cancer (NSCLC) with anti-programmed death (PD)-1 therapy; only a fraction of patients derives durable clinical benefit. In this study, we investigated whether the differentiation status of systemic CD8 T cells predicts the outcome of PD-1 blockade in NSCLC.

Methods: We carried out a prospective study on a total of 77 NSCLC patients receiving anti-PD-1 blockers, among which 47 patients were assigned as a discovery cohort and 30 patients as a validation cohort.

[Tianma Gouteng Decoction regulates MFN2 expression to delay vascular aging in spontaneously hypertensive rats].

We studied the effect of Tianma Gouteng Decoction on vascular aging in spontaneously hypertensive rats(SHRs) to explore the molecular mechanism of the decoction in improving arterial vascular aging by regulating the expression of mitofusin 2(MFN2).Twenty 64-weeks-old SHRs were randomly assigned into the aging group and the treatment group(Tianma Gouteng Decoction 5.48 mg·kg~(-1)).

Immunological significance of prognostic markers for breast cancer based on alternative splicing.

Objectives: Breast cancer (BC) currently has the highest incidence rate. Epigenetic regulation could alter gene expression and is closely related to BC initiation. This study aimed to develop an alternative splicing (AS)-based prognostic signature and clarify its relevance to the tumor immune microenvironment (TIME) status and immunotherapy of BC.

A new species of medicinal leech in the genus Linnaeus, 1758 (Hirudiniformes, Hirudinidae) from Tianjin City, China.

Medicinal leeches in the genus have been utilized for therapeutic procedures for thousands of years. To date, six known species of are widely distributed in different regions of the Eurasian continent. In this study, a new medicinal leech species Liu, is described based upon specimens collected from Tianjin City, China.