Association Between Sugar-Sweetened Beverage Consumption and Frailty Among Older Adults With Hypertension: Evidence From the National Health and Nutrition Examination Survey 1999-2020.

Frailty is a condition characterized by increased vulnerability to adverse health outcomes, particularly among older adults. With the significant prevalence of hypertension and the consumption of sugar-sweetened beverages (SSBs) in this demographic, it is essential to explore their potential combined effects on frailty. This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2020, involving 13,465 hypertensive adults aged 60 and above.

Identification of critical biomarkers and immune landscape patterns in glioma based on multi-database.

Purpose: Glioma is the most prevalent tumor of the central nervous system. The poor clinical outcomes and limited therapeutic efficacy underscore the urgent need for early diagnosis and an optimized prognostic approach for glioma. Therefore, the aim of this study was to identify sensitive biomarkers for glioma.

Exploring the role of OIP5-AS1 in the mechanisms of delayed fracture healing: functional insights and clinical implications.

Objective: Fracture is a common traumatic disease and there is a risk of delayed healing after fracture occurs. This study aimed to explore the regulatory roles and clinical implications of OIP5-AS1 in delayed fracture healing.

Methods: The study included 80 normal fracture healing patients and 80 delayed fracture healing patients.

Distribution of microbial taxa and genes degrading halogenated organic pollutants in the mangroves.

Anthropogenic activities have led to serious contamination of halogenated organic pollutants (HOPs), such as PCBs, PBDEs, and HBCDs, in the mangrove wetland. Biodegradation of HOPs is generally driven by environmental microorganisms harboring dehalogenase genes. However, little is known if HOPs can affect the distributions of HOPs-degrading bacteria and dehalogenase genes in the mangrove wetlands.

Analysis of the positive influence of hyperbaric oxygen therapy on the prognosis and hearing control of patients with noise-induced hearing loss.

Objective: In this study, the research team aimed to explore the therapeutic effectiveness of hyperbaric oxygen therapy (HBOT) for noise-induced hearing loss (NIHL), its influence on patient prognosis, and its impact on hearing to provide valuable clinical evidence.

Methods: Ninety-four patients with NIHL admitted to The First People's Hospital of Changde City, Hunan, China, from May 2021 to January 2023 were selected for this retrospective analysis. Among them, 43 were given conventional treatment (control group) and 51 were given HBOT (observation group).

Visible-light-induced radical cascade sulfonylation/cyclization towards indole-fused pyridine derivatives.

Indole-fused pyridines are an important motif in pharmaceuticals and functional molecules. A visible-light induced Ru(bpy)Cl·6HO catalyzed radical cascade sulfonylation/cyclization strategy for the synthesis of indole-fused pyridine derivatives was developed. Diverse indole-fused pyridines bearing different functional groups were obtained in moderate to good yields.

Machine learning-assisted construction of COPD self-evaluation questionnaire (COPD-EQ): a national multicentre study in China.

Background: Approximately 70% of chronic obstructive pulmonary disease (COPD) is underdiagnosed worldwide. We aimed to develop and validate a COPD self-evaluation questionnaire (COPD-EQ) that is better suited for COPD screening in China.

Methods: We developed a primary version of COPD-EQ based on the Delphi method.

Association between phosphate and 30-day in-hospital mortality in paediatric ICU: a retrospective cohort study.

Background: Death rates in the intensive care unit (ICU) and paediatric ICU (PICU) are approximately 10.8% and 9.13%, respectively.

Reconfigurable Amphiphilic DNA Nanotweezer for Targeted Delivery of Therapeutic Oligonucleotides.

Amphiphilic lipid oligonucleotide conjugates are powerful molecular-engineering materials that have been used for delivery of therapeutic oligonucleotides. However, conventional lipid oligonucleotide conjugates suffer from poor selectivity to target cells due to the nonspecific interaction between lipid tails and cell membranes. Herein, a reconfigurable DNA nanotweezer consisting of a c-Met aptamer and bischolesterol-modified antisense oligonucleotide was designed for c-Met-targeted delivery of therapeutic antisense oligonucleotides.

The association between nutrition risk status assessment and hospital mortality in Chinese older inpatients: a retrospective study.

Purpose: The association between nutritional risk status assessment and hospital mortality in older patients remains controversial. The aim of this study was to assess the relationship between nutritional risk on admission and in-hospital mortality, and explore the best Nutritional Risk Status Screening 2002 (NRS2002) threshold for predicting in-hospital mortality of older inpatients in China.

Method: The elderly inpatients were recruited from a hospital in Hunan Province, China.

Depression and anxiety, peripheral blood inflammatory factors, and stress levels on therapeutic outcomes in patients with chronic wounds.

Background: The incidence of chronic wounds is rising due to an aging population and lifestyle changes in our country. In addition, as the disease spectrum evolves, chronic wounds have become common clinical issues that seriously threaten health and impose significant social and economic burdens.

Aim: To investigate how depression, anxiety, peripheral blood inflammatory factors, and stress levels affect therapeutic outcomes in patients with chronic wounds.

Advances in chimeric antigen receptor T cell therapy for autoimmune and autoinflammatory diseases and their complications.

Chimeric antigen receptor T (CAR-T) cells are genetically engineered T cells expressing transmembrane chimeric antigen receptors with specific targeting abilities. As an emerging immunotherapy, the use of CAR-T cells has made significant breakthroughs in cancer treatment, particularly for hematological malignancies. The success of CAR-T cell therapy in blood cancers highlights its potential for other conditions in which the clearance of pathological cells is therapeutic, such as liver diseases, infectious diseases, heart failure, and diabetes.

Relationship Between the Hemoglobin-to-Red Cell Distribution Width Ratio and in-Hospital Mortality in Patients with Chronic Heart Failure.

Purpose: Hemoglobin (Hb) levels and red cell distribution width (RDW) are standard and widely used parameters that predict clinical outcomes in patients with chronic heart failure (CHF). The Hb to RDW ratio (HRR) provides an incremental clinical prediction, as it reflects the various clinical characteristics of patients. No published data exists in the Medical Information Mart for Intensive Care (MIMIC-IV) and eICU Collaborative Research Database (eICU-CRD) databases on HRR and its association with in-hospital mortality among patients with CHF.

Practical Study on the Participation of Clinical Pharmacists in Multi-Disciplinary Teams Dealing With Nutrition Intervention Management in Ovarian Cancer.

Objective: This study aimed to explore the role of clinical pharmacists in guiding nutritional treatment in a multi-disciplinary team for patients with ovarian cancer (OC) and the significance of pharmaceutical nutritional intervention in overall management and drug administration.

Methods: Fifty-nine patients with OC in our gynaecological oncology ward were retrospectively investigated. The patients were divided into a conventional therapy (CT) group (n = 30) and a pharmaceutical management (PM) group (n = 29) according to different nutritional therapies received.

An anoikis-related gene signature predicts prognosis in patients with acute myeloid leukemia and immunotherapy.

Acute myeloid leukemia (AML) is a malignant blood disorder and the most common type of acute leukemia in adults. Notwithstanding the plethora of therapeutic modalities, a significant cohort of patients fail to respond to treatment and experience relapse. Anoikis, a distinct modality of programmed cell death, has been linked to cancer progression.

A new perspective on targeting pulmonary arterial hypertension: Programmed cell death pathways (Autophagy, Pyroptosis, Ferroptosis).

Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease characterized by elevated pulmonary vascular resistance, progressive increases in pulmonary artery pressures, ultimately leading to right-sided heart failure, and potentially mortality. Pulmonary vascular remodeling is pivotal in PAH onset and progression. While targeted drug therapies have notably ameliorated PAH prognosis, current medications primarily focus on vascular vasodilation, with limited ability to reverse pulmonary vascular remodeling fundamentally, resulting in suboptimal patient prognoses.

Clinical study on the safety and efficacy of remimazolam in hysteroscopic surgery under general anesthesia in elderly patients.

Objective: To evaluate the safety and efficacy of remimazolam in hysteroscopic surgery in elderly patients.

Methods: Following hysteroscopic surgery under selected general anesthesia, 60 elderly patients ASA (American Society of Anesthesiologists) class II-III, >65 years old were randomly assigned to one of two groups: the R group (remimazolam) or the C group (propofol), each with 30 patients. Sufentanil 0.

Differential correlations of refractive error, axial length, and axial length-to-corneal curvature ratio with anterior segment biometrics in myopic refractive surgery candidates.

Purpose: To investigate the correlations of spherical equivalent (SE), axial length (AL), and AL to corneal curvature radius ratio (AL/CR) with anterior segment biometrics in candidates for myopic refractive surgery.

Methods: Anterior segment biometrics of 2,478 myopic refractive surgery candidates measured by Pentacam were collected retrospectively. The anterior segment biometrics included anterior corneal curvature (ACC), posterior corneal curvature (PCC), white-to-white corneal diameter (WTW), central corneal thickness (CCT), corneal volume at 3 mm (CV), anterior corneal astigmatism (ACA), posterior corneal astigmatism (PCA), anterior corneal eccentricity (ACE), posterior corneal eccentricity (PCE), anterior corneal asphericity (ACAP), posterior corneal asphericity (PCAP), anterior chamber depth (ACD), and anterior chamber volume (ACV).