5 results match your criteria: "Central South University (The First People's Hospital of Changde City) Changde 415000[Affiliation]"
Visible-light-induced radical cascade sulfonylation/cyclization towards indole-fused pyridine derivatives.
RSC Adv
January 2025
College of Chemistry and Materials Engineering, Hunan University of Arts and Science, Engineering Technology Research Center of Key Preparation Technology of Biomedical Polymer Materials Changde 415000 China.
Indole-fused pyridines are an important motif in pharmaceuticals and functional molecules. A visible-light induced Ru(bpy)Cl·6HO catalyzed radical cascade sulfonylation/cyclization strategy for the synthesis of indole-fused pyridine derivatives was developed. Diverse indole-fused pyridines bearing different functional groups were obtained in moderate to good yields.
View Article and Find Full Text PDFAn anoikis-related gene signature predicts prognosis in patients with acute myeloid leukemia and immunotherapy.
Am J Cancer Res
November 2024
Department of General Surgery, Guizhou Provincial People's Hospital Guiyang 550002, Guizhou, China.
Acute myeloid leukemia (AML) is a malignant blood disorder and the most common type of acute leukemia in adults. Notwithstanding the plethora of therapeutic modalities, a significant cohort of patients fail to respond to treatment and experience relapse. Anoikis, a distinct modality of programmed cell death, has been linked to cancer progression.
View Article and Find Full Text PDFEfficacy of natural duct specimen extraction versus conventional laparoscopic surgery for rectal cancer: a single-centre retrospective analysis.
Am J Cancer Res
September 2024
Department of General Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City) Changde 415000, Hunan, China.
Article Synopsis
- The study investigates the effectiveness of Natural Orifice Specimen Extraction Surgery (NOSES) compared to traditional laparoscopic surgery for treating rectal cancer, as the condition is becoming more prevalent in younger patients.
- A retrospective analysis of 150 rectal cancer patients was conducted, where those undergoing NOSES were matched with a control group receiving standard laparoscopic surgery to evaluate various surgical and recovery indicators.
- Results showed that the NOSES group had better outcomes, including quicker recovery times and less pain, indicating that NOSES could be a more effective and less invasive option for rectal cancer treatment.
Systemic immunoinflammatory index and prognostic nutrition index for predicting pathologic responses of patients with advanced gastric cancer after neoadjuvant therapy for advanced gastric cancer.
Am J Cancer Res
August 2024
Department of Gastrointestinal Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City) Changde 415000, Hunan, China.
To investigate the value of prognostic nutrition index (PNI) and systemic immunoinflammatory index (SII) for predicting pathological responses of patients with advanced gastric cancer (GC) after neo-adjuvant chemotherapy (NACT). The clinicopathological data of 326 patients with advanced GC who received NACT in Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City) from January 2017 to December 2021 were retrospectively collected. The SII and PNI of patients were calculated.
View Article and Find Full Text PDFProgress of EGFR-TKI and ALK/ROS1 inhibitors in advanced non-small cell lung cancer.
Int J Clin Exp Med
September 2015
Department of Cardiovascular Medicine, Xiangya Hospital, Central South University Changsha 410008, Hunan, China.
To discuss the mechanism and clinical application of EGFR-TKI and ALK/ROS1 inhibitors in non-small cell lung cancer (NSCLC), we reviewed recent available data mainly from PubMed. We found that chemotherapy, progression-free survival (PFS), objective response rate (ORR), and quality of life of patients with advanced NSCLC can be greatly improved in these drugs medication compared with conventional chemotherapy. Though many questions like resistance to EGFR-TKI and ALK/ROS1 inhibitors exist, molecular targeted therapy is an important therapeutic method for the management of NSCLC.
View Article and Find Full Text PDF