129,721 results match your criteria: "Central South University; zhoushenghua@csu.edu.cn.[Affiliation]"

Efficient Capture of ReO4- from Water by Imidazolium-Based Cationic Polymeric Nanotraps.

Chem Asian J

January 2025

University of North Texas, Department of Chemistry, 1508 W Mulberry St, 76201, Denton, UNITED STATES OF AMERICA.

Rhenium represents an irreplaceable metal resource, which finds extensive applications in diverse fields, particularly in the aerospace and petrochemical industry. However, its remarkably low natural abundance and the lack of independent ore deposits pose significant challenges to its extraction and recovery processes. In this study, we present the highly efficient adsorption of perrhenate by a cationic polymeric nanotrap material, namely CPN-3VIm.

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Objective: Muslim patients are an underrepresented community in end-of-life care research, with little evidence around factors that influence the quality and experience of care. The aim of this study was to explore the quality of end-of-life care in the intensive care unit (ICU) from the perspective of next-of-kin family members of Muslim patients.

Design: A qualitative multiple case study design using semistructured interviews with family members of Muslim patients.

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Wild solitary bees face a host of challenges from the simplification of landscapes and biodiversity loss to invasive species and urbanization. Pollinator researchers and restoration workers thus far gave much attention to increase flower cover to reduce the impact of these anthropogenic pressures. Over 30% of bee species need nonfloral resources such as leaves and resin for their survival and reproduction.

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Objectives: Should a young person receive psychotherapy or medication for their depression and on what evidence do we base this decision? In this paper, we test the factors across modalities that may influence comparability between medication and psychotherapy trials.

Methods: We included 92 randomised controlled trials (RCTs) of psychotherapy and medication for child and adolescent depression (mean age 4-18 years). Using meta-analyses, we compared (a) participant characteristics and (b) trial characteristics in medication and psychotherapy trials.

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Potential associations between altered brain function, cognitive deficits and gene expressing profiles in bipolar disorder across three clinical stages.

J Affect Disord

January 2025

Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China. Electronic address:

Aims: We aimed to determine the relationship between altered brain imaging characteristics, cognitive function and profiles of gene expression of bipolar disorder (BD).

Methods: Functional magnetic resonance imaging (fMRI) was presented in three groups of BD participants (depressed, manic and euthymic) and healthy controls. Regional Homogeneity (ReHo) and region of interest based functional analysis combining with neuroimaging-transcription association analysis were utilized to investigate abnormalities and their correlation with clinical symptoms.

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Downregulation of collagen IV deposition and ITGB1-FAK signaling pathway to inhibit adipogenesis: A novel mechanism of swertiamarin in treating type 2 diabetes mellitus.

Int J Biol Macromol

January 2025

International Cooperation Base for Active Substances in Traditional Chinese Medicine in Hubei Province, School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China. Electronic address:

Extracellular matrix (ECM) and integrins are important biological macromolecules. ECM especially collagen IV (COLIV) deposition modulates the integrin-FAK signaling pathway involved in adipogenesis and is strongly associated with insulin resistance. Type 2 diabetes mellitus (T2DM) mice were given swertiamarin (STM) by intragastric administration.

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Study Purpose: Evidence on the effects of sarcopenic obesity (SO) on incident chronic kidney disease (CKD) and rapid kidney function decline (RKFD) in the Chinese population is limited. This study aimed to prospectively examine the associations of SO with incident CKD and RKFD among middle-aged and older Chinese adults.

Study Design And Methods: This prospective cohort study utilized data from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative longitudinal study of Chinese adults aged 45 and older.

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Efficacy and Safety of Sulforaphane Added to Antipsychotics for the Treatment of Negative Symptoms of Schizophrenia: A Randomized Controlled Trial.

J Clin Psychiatry

January 2025

Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, and Department of Psychiatry, New York University School of Medicine, New York, New York.

There are few established treatments for negative symptoms in schizophrenia, which persist in many patients after positive symptoms are reduced. Oxidative stress, inflammation, and epigenetic modifications involving histone deacetylase (HDAC) have been implicated in the pathophysiology of schizophrenia. Sulforaphane has antioxidant properties and is an HDAC inhibitor.

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Groundnut fodder was utilized as a bioresource for the production of cellulases through solid state fermentation (SSF). Aspergillus unguis was initially grown on modified groundnut fodder for cellulase production and the fodder was hydrolyzed by the crude cellulase extract into fermentable hydrolyzate. The highest titer of Filter paperase (FPase), Carboxymethyl cellulase (CMCase), β-glucosidase, and protein content were found to be 11.

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Redox imbalance, including excessive production of reactive oxygen species (ROS) caused by mitochondrial dysfunction and insufficient endogenous antioxidant capacity, is the primary cause of myocardial ischemia‒reperfusion (I/R) injury. In the exploration of reducing myocardial I/R injury, it is found that protecting myocardial mitochondrial function after reperfusion not only reduces ROS bursts but also inhibits cell apoptosis triggered by the release of cytochrome c. Additionally, nuclear factor erythroid 2-related factor 2 (Nrf2) is considered a potential therapeutic target for treating myocardial I/R injury by enhancing the cellular antioxidant capacity through the induction of endogenous antioxidant enzymes.

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Exploring the multifaceted roles of metal-organic frameworks in ecosystem regulation.

J Mater Chem B

January 2025

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Achieving microecological balance is a complex environmental challenge. This is because the equilibrium of microecological systems necessitates both the eradication of harmful microorganisms and preservation of the beneficial ones. Conventional materials predominantly target the elimination of pathogenic microorganisms and often neglect the protection of advantageous microbial species.

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Protective immunity induced by a novel P1 adhesin C-terminal anchored mRNA vaccine against infection in BALB/c mice.

Microbiol Spectr

January 2025

Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical College, Institute of Pathogenic Biology, University of South China, Hengyang, China.

(Mp), a unique pathogen devoid of a cell wall, is naturally impervious to penicillin antibiotics. This bacterium is the causative agent of pneumonia, an acute pulmonary affliction marked by interstitial lung damage. Non-macrolide medications may have potential adverse effects on the developmental trajectory of children, thereby establishing macrolides as the preferred treatment for in pediatric patients.

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Fetal Corpus Callosum Anomalies: A Review of Underlying Genetic Disorders and Prenatal Testing Options.

J Ultrasound Med

January 2025

BCNatal Fetal Medicine Research Center (Hospital Clınic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Catalonia, Spain.

Anomalies of the corpus callosum (CC) are amongst the most common fetal Central Nervous System (CNS) anomalies detectable on ultrasound. Underlying genetic disease plays an important part in defining prognosis. Associations with aneuploidy and submicroscopic chromosomal deletions or duplications have been well demonstrated using chromosomal microarray analysis.

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Nurse-Led/Involved Home-Based Interventions for Older Adults With Chronic Obstructive Pulmonary Disease (COPD): A Mixed-Methods Systematic Review.

J Clin Nurs

January 2025

School of Nursing and Midwifery College of Health, Medicine, and Wellbeing Hunter and Medical Research Institute Healthcare Transformation Research Program, The Centre for Transformative Nursing, Midwifery, and Health Research, Hunter New England Local Health District, University of Newcastle, Newcastle, New South Wales, Australia.

Aims: To determine the effectiveness of nurse-led/involved home-based interventions for older people with COPD and to explore the experiences of older people and nurses with the interventions.

Design: A mixed-methods systematic review following the JBI methodology for mixed-methods systematic reviews.

Data Sources: The search included relevant and peer-reviewed studies published from January 2010 to December 2023 in CINAHL, MEDLINE, Cochrane Central Register of Controlled Trials, PsycINFO, EMBASE, JBI, EMCARE and ProQuest.

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The two-dimensional lamellar materials disperse platinum sites and minimize noble-metal usage for fuel cells, while mass transport resistance at the stacked layers spurs device failure with a significant performance decline in membrane electrode assembly (MEA). Herein, we implant porous and rigid sulfonated covalent organic frameworks (COF) into the graphene-based catalytic layer for the construction of steric mass-charge channels, which highly facilitates the activity of oxygen reduction reactions in both the rotating disk electrode (RDE) measurements and MEA device tests. Specifically, the normalized mass activity is remarkably boosted by 3.

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Background: The relationship between loneliness and internalizing disorders has been well established in psychological research. This study aims to build on existing research by exploring how different components of loneliness-isolation, relational connectedness, and collective connectedness-interact with ego-resilience to influence anxiety, depression, and hopelessness.

Methods: The study participants were young adults ( = 337) who completed the University of California-Los Angeles Loneliness Scale, Ego Resilience Scale, Centre for Epidemiological Studies Depression Scale, State-Trait Anxiety Scale, and Beck Hopelessness Scale.

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Risk Prediction of Liver Injury in Pediatric Tuberculosis Treatment: Development of an Automated Machine Learning Model.

Drug Des Devel Ther

January 2025

Department of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, 410004, People's Republic of China.

Purpose: Drug-induced liver injury (DILI) is one of the most common and serious adverse drug reactions related to first-line anti-tuberculosis drugs in pediatric tuberculosis patients. This study aims to develop an automatic machine learning (AutoML) model for predicting the risk of anti-tuberculosis drug-induced liver injury (ATB-DILI) in children.

Methods: A retrospective study was performed on the clinical data and therapeutic drug monitoring (TDM) results of children initially treated for tuberculosis at the affiliated Changsha Central Hospital of University of South China.

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Efficacy, safety, and quality of life of dabrafenib plus trametinib treatment in Chinese patients with mutation-positive metastatic non-small cell lung cancer.

Transl Lung Cancer Res

December 2024

Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.

Background: Dabrafenib plus trametinib (Dab + Tram) is an approved targeted therapy in patients with mutated metastatic non-small cell lung cancer (NSCLC). Here, we report the efficacy, safety, and quality of life (QoL) results of Dab + Tram treatment in Chinese patients with mutation-positive metastatic NSCLC.

Methods: This is a single-arm, open-label, multicentre, phase II study (NCT04452877).

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Background: High mobility group box 1 (HMGB1) plays an essential role in various pathological conditions, including inflammation, fibrosis, autoimmune diseases, and carcinogenesis. The quantification of HMGB1 in body fluids holds promise for clinical applications.

Objectives: This study aimed to isolate high-affinity single-stranded DNA (ssDNA) aptamers that target HMGB1.

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Background: Anti-citrullinated peptide antibodies (ACPA)-negative (ACPA-) rheumatoid arthritis (RA) presents significant diagnostic and therapeutic challenges due to the absence of specific biomarkers, underscoring the need to elucidate its distinctive cellular and metabolic profiles for more targeted interventions.

Methods: Single-cell RNA sequencing data from peripheral blood mononuclear cells (PBMCs) and synovial tissues of patients with ACPA- and ACPA+ RA, as well as healthy controls, were analyzed. Immune cell populations were classified based on clustering and marker gene expression, with pseudotime trajectory analysis, weighted gene co-expression network analysis (WGCNA), and transcription factor network inference providing further insights.

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Cephalometric analysis of Indian races: A systematic review.

Natl J Maxillofac Surg

November 2024

Department Oral and Maxillofacial Surgery, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

This study is intended to review the cephalometric data pertaining to the diverse Indian populace through a systematic literature survey. To conduct a systematic review of literature, an electronic search was done on Medline, Embase, and Central databases. The available data were categorized based on the existing five geographic locations of the country (north, south, east, west, and central India) and analyzed.

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Basic helix-loop-helix ARNT like 1 regulates the function of immune cells and participates in the development of immune-related diseases.

Burns Trauma

January 2025

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Renmin South Road, Wuhou District, Chengdu 610041, China.

The circadian clock is an internal timekeeper system that regulates biological processes through a central circadian clock and peripheral clocks controlling various genes. Basic helix-loop-helix ARNT-like 1 (), also known as aryl hydrocarbon receptor nuclear translocator-like protein 1 (), is a key component of the circadian clock. The deletion of alone can abolish the circadian rhythms of the human body.

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Investigating the Shared Genetic Architecture Between Psychiatric Disorders and Executive Function.

Biol Psychiatry Glob Open Sci

November 2024

Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

Background: Evidence for widespread comorbidity of executive dysfunctions with psychiatric disorders suggests common mechanisms underlying their pathophysiology. However, the shared genetic architectures between psychiatric disorders and executive function (EF) remain poorly understood.

Methods: Leveraging large genome-wide association study datasets of European ancestry on bipolar disorder ( = 353,899), major depressive disorder ( = 674,452), and schizophrenia ( = 130,644) from the Psychiatric Genomics Consortium and iPSYCH and a common factor of EF ( = 427,037) from UK Biobank, we systematically investigated the shared genomic architectures between psychiatric disorders and EF with a set of statistical genetic, functional genomic, and gene-level analyses.

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Aim: To compare the macular and optic nerve perfusion and vascular architecture using optical coherence tomography angiography (OCTA) in normal eyes of Egyptian (Caucasians) and South Asian (Asians) volunteers.

Methods: Cross-sectional analytical OCTA study performed on 90 eyes of South Asian (=45) and Egyptians (=45) were analyzed. All participants underwent best-corrected visual acuity test, slit lamp, and fundus examination.

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