Convenient rapid prototyping microphysiological niche for mimicking liver native basement membrane: Liver sinusoid on a chip.

Liver is responsible for the metabolization processes of up to 90 % of compounds and toxins in the body. Therefore liver-on-a-chip systems, as an in vitro promising cell culture platform, have great importance for fundamental science and drug development. In most of the liver-on-a-chip studies, seeding cells on both sides of a porous membrane, which represents the basement membrane, fail to resemble the native characteristics of biochemical, biophysical, and mechanical properties.

The application of qNMR for the determination of rosuvastatin in tablet form.

In this study, quantative nuclear magnetic resonance (qNMR) method was used to determine the content of rosuvastatin in tablet. Linearity, range, limit of detection (LOD), limit of quantification (LOQ), accuracy, and precision were determined in validation study of rosuvastatin. Furthermore, validation study of rosuvastatin was performed with high performance liquid chromatography (HPLC).

The Raman, SERS and computational studies of 3,5-dimethoxy-4-hydroxycinnamic acid and its silver complex.

Optimized chemical structure, Raman and SERS spectra of 3,5-dimethoxy-4-hydroxycinnamic acid (35D4HCA) molecule and its silver (Ag) complex were calculated using time-dependent density functional theory in conjunction with B3LYP functional and LANL2DZ/6-311 + G(d,p) basis sets. Moreover, excitation and HOMO-LUMO energies were computed by the same level of theory. Because of the fact that energy of excitation electronic transition depends on infinite lifetime approximation, Raman activities were calculated under this approximation.