95,067 results match your criteria: "Central R&D Institute[Affiliation]"

A perspective on field-effect in energy and environmental catalysis.

Chem Sci

December 2024

Hunan Joint International Research Center for Carbon Dioxide Resource Utilization, State Key Laboratory of Powder Metallurgy, School of Physics, Central South University Changsha 410083 P. R. China

The development of catalytic technologies for sustainable energy conversion is a critical step toward addressing fossil fuel depletion and associated environmental challenges. High-efficiency catalysts are fundamental to advancing these technologies. Recently, field-effect facilitated catalytic processes have emerged as a promising approach in energy and environmental applications, including water splitting, CO reduction, nitrogen reduction, organic electrosynthesis, and biomass recycling.

View Article and Find Full Text PDF

Consensus on the lung cancer management after third-generation EGFR-TKI resistance.

Lancet Reg Health West Pac

December 2024

Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Article Synopsis
  • Lung cancer is the most common type of cancer in the Asia-Pacific region, with non-small cell lung cancer (NSCLC) making up about 85% of cases, and a significant mutation rate of 40-60% in Asian patients with lung adenocarcinoma.
  • Third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) have improved treatment for NSCLC with mutations, but managing resistance to these drugs is still a major issue with no standardized guidelines.
  • A set of recommendations has been developed, integrating international guidelines and regional clinical experiences, to help healthcare providers classify resistance, conduct clinical testing, and devise treatment strategies for patients struggling with resistance to third-generation EGFR-TKIs.
View Article and Find Full Text PDF

Objectives: Heart rate control using beta-blockers in sepsis has traditionally been avoided because of concerns with worsening cardiac index and organ perfusion. Recent studies has explored the possible beneficial effects of targeted heart rate control in patients with septic shock who have tachycardia despite initial resuscitation. We performed a systematic review and meta-analysis to explore the effects of heart rate control in septic shock patients.

View Article and Find Full Text PDF

Heat and drought events are increasing in frequency and intensity, posing significant risks to natural and agricultural ecosystems with uncertain effects on the net ecosystem CO exchange (NEE). The current Vegetation Photosynthesis and Respiration Model (VPRM) was adjusted to include soil moisture impacts on the gross ecosystem exchange (GEE) and respiration ( ) fluxes to assess the temporal variability of NEE over south-western Europe for 2001-2022. Warming temperatures lengthen growing seasons, causing an increase in GEE, which is mostly compensated by a similar increment in .

View Article and Find Full Text PDF

Unravelling the genetic architecture of soybean tofu quality traits.

Mol Breed

January 2025

Institute of Plant Breeding, Seed Science and Population Genetics, University of Hohenheim, 70599 Stuttgart, Germany.

Unlabelled: Tofu is a popular soybean ( (L.) Merr.) food with a long tradition in Asia and rising popularity worldwide, including Central Europe.

View Article and Find Full Text PDF

Traditional Uses, Phytochemistry, Pharmacology and Toxicology of : A Critical Review and Future Perspectives.

Drug Des Devel Ther

January 2025

Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.

Medicinal plants are fundamental sources of natural products with high chemical diversity and specificity as novel lead compounds with diverse pharmacological activities. . is an important traditional Chinese medicine used to treat fever caused by cold, wind-fire toothache, headache, bruises and sprains, irregular menstruation, and infantile eczema.

View Article and Find Full Text PDF

Purpose: Spectral-domain OCT angiography (SD-OCTA) scans were used in an algorithm developed for swept-source OCT angiography (SS-OCTA) scans to determine if SD-OCTA scans yielded similar results for the measurement of hyperreflective foci (HRF) in intermediate age-related macular degeneration (iAMD).

Design: Retrospective study.

Participants: Forty eyes from 35 patients with iAMD.

View Article and Find Full Text PDF

An error was found in the affiliations of the author in the article titled 'Investigation of the Expression and Regulation of SCG5 in the Context of the Chromogranin-Secretogranin Family in Malignant Tumors'', published in Protein and Peptide Letters, 2024, 31(9), 657-666 [1]. Details of the error and a correction are provided here. Original: *Address correspondence to these authors at the Department of Thoracic Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hospital, Yancheng 224000, P.

View Article and Find Full Text PDF

Real-world evidence of ocrelizumab in Chilean patients with multiple sclerosis.

Mult Scler

January 2025

Departamento de Neurología, Pontificia Universidad Católica de Chile, Santiago, Chile.

Article Synopsis
  • The study investigates the safety and effectiveness of ocrelizumab in Hispanic/Latino individuals with multiple sclerosis (MS), highlighting the need for real-world data from underrepresented populations in clinical trials.
  • Out of 305 participants, the majority had relapsing-remitting MS, and the results showed minimal relapses and a significant reduction in MRI activity, with only 12.4% experiencing confirmed disability worsening.
  • While the treatment was largely safe, with a low rate of serious infections and a consistent profile of outcomes, the study confirms ocrelizumab's effectiveness in this demographic at a specialized MS center.
View Article and Find Full Text PDF

Cholangiocarcinoma (CCA) is a highly malignant hepatobiliary tumor characterized by limited treatment options and poor prognosis. The recent rise of immunotherapy has significantly influenced research in this field. This study presents a bibliometric analysis of 416 articles retrieved from the WOSCC, Wan fang Data, CNKI and VIP databases, spanning contributions from 32 countries, 589 institutions and 3,200 authors.

View Article and Find Full Text PDF

Phenylketonuria (PKU) is characterized by an autosomal recessive mutation in the phenylalanine hydroxylase (PAH) gene. Impaired PAH enzyme activity leads to the accumulation of phenylalanine (Phe) and its metabolites in the bloodstream, which disrupts the central nervous system and causes psychomotor retardation. Early diagnosis of PKU is essential for timely intervention.

View Article and Find Full Text PDF

Background: Hypereosinophilic syndromes (HES) are a heterogenous group of eosinophilic disorders. To date, only retrospective studies of limited sample-size and/or follow-up duration are available.

Methods: The COHESion study is a national prospective multicenter multidisciplinary cohort recruiting both adults or children with the spectrum of eosinophilic disorders (including reactive HE/HES [HE/HES-R], idiopathic HES [HES-I], lymphocytic HES [HES-L], neoplastic HE/HES [HE/HES-N], HE of unknown significance [HE-US], as well as IgG4-related disease [IgG4RD] or ANCA-negative eosinophilic granulomatosis with polyangiitis [EGPA] overlaps).

View Article and Find Full Text PDF

Facilitated Self-Adjusting Mechanism with Mn Additive in Electrolyte for Ammonium-Ion Hybrid Supercapacitors.

Small

January 2025

State Key Laboratory of Silicon and Advanced Semiconductor Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310058, China.

Article Synopsis
  • Ammonium-ion hybrid supercapacitors (AIHSCs) are recognized for their safety and eco-friendliness, with manganese oxides being promising cathode materials despite challenges from side electrochemical reactions in aqueous electrolytes.
  • The study investigates the behavior of β-/γ-MnO electrodes and identifies side reactions, including MnO dissolution, re-deposition, and NH insertion, which result in irreversible structural changes and reduced performance over time.
  • To enhance performance and stability, a self-adjusting mechanism is proposed, incorporating trace manganese in the electrolyte, leading to an AIHSC with impressive energy and power densities of 60.2 Wh/kg and 5000 W/kg.
View Article and Find Full Text PDF
Article Synopsis
  • Colorectal adenocarcinoma (COAD) is a significant cancer type, and this study investigates the role of wound healing-related genes in its progression to help improve diagnosis and treatment.
  • Seventy wound healing-associated genes were identified, leading to the discovery of four key genes (MMP2, FN1, NF1, PTK7) that show overexpression in COAD, which may serve as potential diagnostic markers.
  • These hub genes are linked to poor patient outcomes and tumor-promoting activities, with further implications for drug resistance and immune response in the context of COAD progression.
View Article and Find Full Text PDF

Intracranial Structural Malformations in Children in Tibet: CT and MRI Findings in a Single Tertiary Center.

Curr Med Imaging

January 2025

Department of Radiology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, P.R.China.

Objectives: The objective of this study was to summarize the findings of children's intracranial congenital or developmental malformations found during imaging procedures in the Tibetan plateau.

Methods: We retrospectively reviewed the imaging data of the suspected patients who presented with the central nervous system (CNS) malformations and were enrolled either through the clinic or after ultrasound examinations between June 2019 and June 2023 in our institution. All imaging data were interpreted by two experienced radiologists through consensus reading.

View Article and Find Full Text PDF

Enhancing the Performance of Hole-Conductor-Free Printable Mesoscopic Perovskite Solar Cells through Polyaniline-Mediated Iodine Recycling and Defect Passivation.

Small

January 2025

Michael Grätzel Center for Mesoscopic Solar Cells, Wuhan National Laboratory for Optoelectronics, Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, P. R. China.

Printable mesoscopic perovskite solar cells (p-MPSCs) provide an opportunity for low-cost manufacturing of photovoltaics. However, the performance of p-MPSCs is severely compromised by iodine defects. This study presents a strategy by incorporating polyaniline (PANI) to achieve both iodine recycling and iodine defect passivation to significantly improve the performance of p-MPSCs.

View Article and Find Full Text PDF

N,O Co-Doped Carbon Spheres Enable Stable Anode-Less Sodium Metal Batteries.

Small Methods

January 2025

Hunan Provincial Key Laboratory of Chemical Power Sources, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P. R. China.

Anode-less sodium metal batteries (SMBs) suffer from the formation of Na dendrites and inactive Na on an anode substrate though showing advantages of high energy densities and low costs. Herein, N,O co-doped carbon spheres (NOCS), which are synthesized via a scalable polymerization and pyrolysis method, are employed as a thin and stable sodiophillic nucleation layer on the Cu foil. Combined with electrochemical measurements, Na deposition morphology observations and density functional theory calculations, it is revealed that the introduced N and O heteroatoms can greatly enhance the adsorption of Na on the carbon substrate and reduce the nucleation overpotential, thus forming sufficient seeding sites and guiding homogeneous Na deposition.

View Article and Find Full Text PDF

In recent years, porphyrins have been frequently reported as photocatalysts due to their fascinating photochemical properties. However, porphyrins have the same shortcomings as other homogeneous photocatalysts, such as poor stability and difficulty in recovering. To solve this problem, it is a good strategy to form a porphyrin-based metal-organic framework (PMOF) by modifying porphyrin functional groups and adding metals as nodes to connect and control the arrangement of porphyrins.

View Article and Find Full Text PDF

Fine-Tuning Intra/Inter-Molecular Interaction via Ternary Copolymerization Strategy to Obtain Efficient Polymer Donors.

Small

January 2025

Jiangxi Province Key Laboratory of Functional Crystalline Materials Chemistry, School of Chemistry and Chemical Engineering, Jiangxi University of Science and Technology, 156 Ke Jia Avenue, Ganzhou, 341000, P. R. China.

Incorporating a third component through ternary copolymerization strategy has proven to be a promising and effective approach for further improving the device performance of polymer donors. However, terpolymer donors typically exhibit negative effects on molecular stacking and weaken charge transport due to the irregular distribution of the polymer skeleton. Herein, two terpolymers PBBQ-5 (5% ff-Qx) and PBBQ-10 (10% ff-Qx) are developed by introducing the difluoro-2-(3-hexyldecyloxy) quinoxaline (ff-Qx) to the main chain of PM6.

View Article and Find Full Text PDF

Single-atom nanozymes (SAzymes), with their superior enzyme-like catalytic activity, have emerged as promising candidates for oncology therapeutics. The well-defined structures of SAzymes make them well predictable by experiences and theoretical calculation. However, the effects of metal center species and coordination environments on enzyme-like activity are variable, and screening catalytic activity by artificial experiments is challenging.

View Article and Find Full Text PDF

Research Progress and Perspectives on Anti-Poisoning Hydrogen Oxidation Reaction Electrocatalysts for Hydrogen Fuel Cells.

Small

January 2025

National Innovation Platform (Center) for Industry-Education Integration of Energy Storage Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.

As global demand for clean and sustainable energy continues to rise, fuel cell technology has seen rapid advancement. However, the presence of trace impurities like carbon monoxide (CO) and hydrogen sulfide (H₂S) in hydrogen fuel can significantly deactivate the anode by blocking its active sites, leading to reduced performance. Developing electrocatalysts that are resistant to CO and H₂S poisoning has therefore become a critical priority.

View Article and Find Full Text PDF

Establishing the reference intervals of plasma PLG, FXII activity, and FXIII antigen in healthy adults in Guangzhou.

BMC Cardiovasc Disord

January 2025

Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue Central, Guangzhou, 510280, P. R. China.

Objective: To establish the reference intervals of plasma Plasminogen, Factor XII activity, and Factor XIII Antigen in healthy adults in Guangzhou.

Methods: A total of 168 young people (75 males and 93 females, aged 18-65 years) who underwent physical examination in Zhujiang Hospital of Southern Medical University from 2020 to 2022 were recruited. Sysmex CS5100 automatic coagulation analyzer and matching reagents were used to detect Plasminogen.

View Article and Find Full Text PDF

G6PD protects against cerebral ischemia-reperfusion injury by inhibiting excessive mitophagy.

Life Sci

January 2025

Central Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China. Electronic address:

Article Synopsis
  • The study investigates the role of glucose-6-phosphate dehydrogenase (G6PD) in exacerbating brain damage caused by cerebral ischemia-reperfusion injury (CIRI) after a stroke.
  • Researchers used various methods, including gene analysis and protein studies, to show that G6PD levels increase after ischemic events and that reducing G6PD leads to worsened brain damage and cell survival in models of ischemia.
  • The findings suggest a significant link between G6PD and mitophagy, indicating that manipulating G6PD levels could help develop new treatments for brain damage resulting from strokes.
View Article and Find Full Text PDF

Vanzacaftor-tezacaftor-deutivacaftor for children aged 6-11 years with cystic fibrosis (RIDGELINE Trial VX21-121-105): an analysis from a single-arm, phase 3 trial.

Lancet Respir Med

December 2024

Population Policy and Practice Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. Electronic address:

Article Synopsis
  • Vanzacaftor-tezacaftor-deutivacaftor is a new CFTR modulator showing safety and effectiveness in phase 2 trials for adults with cystic fibrosis, leading to a study evaluating its use in children aged 6-11.
  • This phase 3 trial, called RIDGELINE, involved participants from 33 clinical sites across eight countries, focusing on children with specific CFTR variants and stable health conditions.
  • The study aimed to assess the drug's safety, tolerability, and efficacy over 24 weeks, with primary outcomes evaluated through various health metrics and participant feedback.
View Article and Find Full Text PDF

Unveiling Schizophrenia: a study with generalized functional linear mixed model via the investigation of functional random effects.

Biostatistics

December 2024

Center for Applied Statistics, School of Statistics, Renmin University of China, No. 59 Zhongguancun Street, Beijing, 100872, P.R. China.

Previous studies have identified attenuated pre-speech activity and speech sound suppression in individuals with Schizophrenia, with similar patterns observed in basic tasks entailing button-pressing to perceive a tone. However, it remains unclear whether these patterns are uniform across individuals or vary from person to person. Motivated by electroencephalographic (EEG) data from a Schizophrenia study, we develop a generalized functional linear mixed model (GFLMM) for repeated measurements by incorporating subject-specific functional random effects associated with multiple functional predictors.

View Article and Find Full Text PDF