55 results match your criteria: "Central Lisbon University Hospital[Affiliation]"

Histomorphometric parameters of iliac bone in healthy individuals: Systematic review and meta-analysis.

Bone

January 2025

Nephrology Department, Laboratorio de Fisiopatologia Renal 16 (LIM 16), Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Despite its invasive character, bone biopsy followed by histomorphometry remains the gold standard for diagnosing and classifying many metabolic bone diseases. However, the interpretation of histomorphometric parameters requires comparison with average values obtained from a proper control group, which are only available for some populations, and reference standards still need to be published. Therefore, our objective was to estimate average values for bone histomorphometric parameters overall, by age, gender, and race (White and Black) categories of healthy adult individuals, based on a systematic review and meta-analysis of clinical studies.

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OrthoMortPred: Predicting one-year mortality following orthopedic hospitalization.

Int J Med Inform

December 2024

Faculty of Medicine and Biomedical Sciences, University of Algarve, Faro, Portugal; Central Lisbon University Hospital Center, CRI-Orthopedic Traumatology, Lisboa, Portugal.

Objective: Predicting mortality risk following orthopedic surgery is crucial for informed decision-making and patient care. This study aims to develop and validate a machine learning model for predicting one-year mortality risk after orthopedic hospitalization and to create a personalized risk prediction tool for clinical use.

Methods: We analyzed data from 3,132 patients who underwent orthopedic procedures at the Central Lisbon University Hospital Center from 2021 to 2023.

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The Role of Deep Inferior Epigastric Perforator and Thoracodorsal Artery Perforator Flaps in Head and Neck Reconstruction.

Oral Maxillofac Surg Clin North Am

November 2024

Department of Plastic and Maxillofacial Surgery, Uppsala University Hospital, VO. Plastik och Käkkirurgi, ing 85, 9 v, Akademiska Sjukhuset, Uppsala 75185, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Article Synopsis
  • Head and neck reconstruction has significantly improved to better replace missing tissues while reducing donor site complications.
  • The deep inferior epigastric perforator flap is utilized for reconstructing large defects in areas like the tongue, orbitomaxillary region, and scalp.
  • The thoracodorsal artery perforator flap offers a versatile option for harvesting various chimeric flaps from the subscapular system.
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Cognitive Dysfunction Screening in Peritoneal Dialysis Patients: A Cross-Sectional Study.

Indian J Nephrol

May 2024

Department of Nephrology, Central Lisbon University Hospital Centre, Hospital Curry Cabral, Lisbon, Portugal.

Article Synopsis
  • - The study examined the prevalence of mild cognitive impairment (MCI) among patients undergoing peritoneal dialysis (PD) and found that over half of the patients (65% by one test and 33% by another) showed signs of MCI, which poses risks like peritonitis and increased mortality.
  • - Factors associated with MCI included older age, lower education levels, physical assistance requirements, a specific type of PD modality, and greater overall health issues (measured by the Charlson comorbidity index). Lower dialysis adequacy (Kt/V) and diet quality (nPCR) were also linked to MCI.
  • - The findings highlight the need for better cognitive health monitoring and management in PD patients, as those with
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Article Synopsis
  • Prolonged high blood sugar (hyperglycemia) in diabetes can lead to significant complications, and recent evidence suggests it affects these conditions through changes in DNA methylation.
  • Researchers analyzed DNA from type 1 diabetes patients with different average blood sugar levels over 5 years, focusing on groups with better control (HbA1c<7%) versus poorer control (HbA1c>8%).
  • The study found 8,385 methylated DNA sites linked to 1,802 genes, revealing patterns related to important pathways and specific gene regions that could help explain chronic complications in type 1 diabetes, even in patients without obvious symptoms.
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Strategies for nursing care of critically ill multicultural patients: A scoping review.

J Clin Nurs

August 2024

Faculty of Health Sciences and Nursing, Interdisciplinary Health Research Center, Portuguese Catholic University, Lisbon, Portugal.

Background: In society, people live in a social reality where multiculturalism is an increasingly relevant and prevalent topic in their contexts. Facing this, caring for multicultural patients in an emergency service or intensive care unit setting requires a high level of cultural competence due to the complexity, vulnerability of the patient, rapid changes in hemodynamic status, involvement of the family, their informational needs.

Objective: To map the strategies for nursing care of critically ill multicultural patients.

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Article Synopsis
  • The study evaluates the CUBN/MPO ratio as a possible biomarker for aggressive T1 bladder cancer, aiming to improve early intervention and patient survival.
  • Urine samples from 30 patients with high-grade T1 bladder cancer were analyzed, revealing that those with a low CUBN/MPO ratio had a higher risk of cancer recurrence and progression.
  • The findings suggest the CUBN/MPO ratio could be a valuable prognostic tool; however, additional research on larger samples is needed to confirm these results.
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Objectives: Referral for liver transplant (LT) following acute variceal bleeding (AVB) varies widely. We aimed to characterize and assess its impact on clinical outcomes.

Methods: Observational retrospective cohort including cirrhosis patients with AVB from 3 hospitals in Lisbon, Portugal, from 2018 to 2019.

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Acute-on-Chronic Liver Failure Remains a Minor Indication for Liver Transplant in Portugal.

GE Port J Gastroenterol

December 2023

Transplant Unit, Curry Cabral Hospital, Central Lisbon University Hospital Center, Nova Medical School, Nova University, Lisbon, Portugal.

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Alcohol Consumption Post-Liver Transplantation: A Cross-Sectional Study.

GE Port J Gastroenterol

October 2023

Transplant Unit, Curry Cabral Hospital, Central Lisbon University Hospital Center, Nova Medical School, Nova University, Lisbon, Portugal.

Background: Listing patients with alcohol-associated liver disease (ALD) for liver transplant (LT) remains challenging especially due to the risk of alcohol resumption post-LT. We aimed to evaluate post-LT alcohol consumption at a Portuguese transplant center.

Methods: We conducted a cross-sectional study including LT recipients from 2019 at Curry Cabral Hospital, Lisbon, Portugal.

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Background: The decision of initiating treatment for multiple sclerosis (MS) with a high-efficacy DMT (HE DMT) or non-high-efficacy DMT (non-HE DMT) is influenced by several factors, including risk perception of patients and physicians.

Objective: Investigate the influence of physicians' risk perception on decision-making when switching treatments for MS and the reasons for switching.

Methods: Data were drawn from the Adelphi Real-World MS Disease-Specific Program (a retrospective survey) and analysis included people with RMS identified between 2017- 2021.

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Postictal psychosis (PIP) is one of the most common types of psychosis in epileptic patients. By virtue of the paucity of research on PIP, its pathophysiology remains not completely understood. Our case report describes a clinical picture of PIP, characterized by pleomorphic features, with neither Schneider's firstrank symptoms nor negative symptoms of schizophrenia, in a longstanding epileptic female patient with a history of nonadherence to antiepileptic treatment and poorly controlled seizures.

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Article Synopsis
  • The study investigates whether combining intravenous thrombolysis (IVT) with endovascular thrombectomy (EVT) is more effective and safe for patients with mild acute ischemic stroke and large vessel occlusion compared to IVT alone.
  • A total of 1,037 patients were analyzed, with 312 undergoing matched comparisons. The results showed that IVT plus EVT was linked to worse functional outcomes despite no significant safety advantage when compared to IVT alone.
  • Patients receiving the combination treatment experienced higher rates of certain hemorrhagic events, indicating the need for careful evaluation when considering treatment methods for mild strokes.
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Introduction The reorganization of healthcare services during the COVID-19 pandemic was associated with compromised management of conditions not related to the pandemic. Methods A retrospective descriptive case series study was carried out that included patients followed up at the Spine Deformities (SD) consultation at Centro Hospitalar e Universitário Lisboa Central from January 2019 through December 2021 regarding diagnosis, treatment, referral, and the number of consultations performed. Results Referrals significantly dropped in 2020 (p<0.

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Background: In the early COVID-19 pandemic concerns about the correct choice of analgesics in patients with COVID-19 were raised. Little data was available on potential usefulness or harmfulness of prescription free analgesics, such as paracetamol. This international multicentre study addresses that lack of evidence regarding the usefulness or potential harm of paracetamol intake prior to ICU admission in a setting of COVID-19 disease within a large, prospectively enrolled cohort of critically ill and frail intensive care unit (ICU) patients.

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Ultrasound showing an anechoic collection with interspersed echogenic foci (blue arrows - gas bubbles) proximal to the hyperechoic bone flap (red asterisk; post-decompressive craniectomy). Serratia marcescens was isolated from the collected fluid. Bedside ultrasound can be a reliable and effective tool to aid in the diagnosis of bone flap infections.

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Article Synopsis
  • Direct oral anticoagulants (DOACs) are effective for preventing strokes in atrial fibrillation patients, but timing of initiation after an acute ischaemic stroke (AIS) is uncertain.
  • An international trial (ELAN) is comparing early initiation (within 48 hours or day 6-7 after stroke) versus late initiation (3-14 days post-stroke) for 2000 participants.
  • The study will assess safety and efficacy outcomes, particularly the risk of bleeding and recurrent strokes, at 30 and 90 days post-randomization.
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Contemporary prevalence of coronary artery disease in patients referred for heart valve surgery.

J Cardiovasc Surg (Torino)

October 2022

Department of Cardiology, Central Lisbon University Hospital Center, Hospital of Santa Marta, Lisbon, Portugal.

Background: Patients undergoing heart valve surgery are routinely evaluated for the presence of coronary artery disease (CAD). Currently, concomitant valve intervention and surgical revascularization is recommended when there is obstructive CAD. The aim of our study was to evaluate the prevalence of CAD, its treatment strategies, and their prognostic implications in a contemporary population of patients with valvular heart disease (VHD) referred for valve surgery (HVS).

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Endocarditis is an inflammation of the endocardium and is characterized by the presence of vegetation, which may occur in the context of infectious or non-infectious diseases. Despite the higher rate of infective endocarditis diagnosis, it may also surge in other non-infectious conditions such as cancer or chronic inflammatory syndromes. Cancer defines a hypercoagulable state, and cancer-associated thrombophilia can have a diverse clinical presentation, most commonly venous thromboembolism and rarely non-bacterial thrombotic endocarditis (NBTE).

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The Impact of Donor Risk Index, Recipients' and Operative Characteristics on Post Liver Transplant One-Year Graft Failure: A Cohort Analysis.

GE Port J Gastroenterol

August 2023

Transplant Unit, Curry Cabral Hospital, Central Lisbon University Hospital Center, Nova Medical School, Nova University, Lisbon, Portugal.

Background And Aims: The donor risk index (DRI) quantifies donor-related characteristics potentially associated with increased risk of early graft failure. We aimed to assess the impact of the DRI, recipient and perioperative factors on post liver transplant (LT) outcomes.

Methods: This was a single-center retrospective cohort study including all adult (≥18 years) patients who underwent LT from 01/2019 to 12/2019 at Curry Cabral Hospital, Lisbon, Portugal.

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A Multinational Study of The Impact of Covid-19 On Urologic Surgery Residency and Wellbeing.

Urology

August 2022

Department of Urology, MedStar Georgetown University Hospital, Washington, DC; MedStar Health, Office of Physician Wellbeing, University of Viena, Columbia, MD. Electronic address:

Objective: To assess changes to the experiences and wellbeing of urology trainees in the United States (US) and European Union (EU) during the COVID-19 pandemic.

Methods: A 72-item anonymous online survey was distributed September 2020 to urology residents of Italy, France, Portugal, and the US. The survey assessed burnout, professional fulfillment, loneliness, depression and anxiety as well as 38 COVID specific questions.

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