Aromaticity-Photovoltaic Property Relationship of Triphenylamine-Based D-π-A Dyes: Leads from DFT Calculations.

D-π-A-based dyes find a wide range of applications in molecular electronics and photovoltaics in general and dye-sensitized solar cells (DSSC) in particular. We speculated whether there exists a relationship between the degree of aromaticity of the π-spacers used in the D-π-A type dyes and their structural, electronic, energetic, photophysical, and intramolecular charge transfer properties. Triphenylamine (TPA) and cyanoacrylic acid (CAA) have been chosen as the donor and acceptor, respectively.

Non-enzymatic reduction of Cr (VI) and it's effective biosorption using heat-inactivated biomass: A fermentation waste material.

The effectiveness of heat-inactivated fungal biomass a fermentation waste of newly isolated laccase enzyme producer Leiotrametes flavida was studied for Cr (VI) removal in water and applied for Cr (VI) removal from tannery effluent. Adsorption parameters pH, biomass concentration and contact time were optimized using Box-Behnken design of response surface methodology. The adsorption process fits the Langmuir isotherm.

Switch-on effect on conformation-specific arylamine-DNA adduct by cyclometalated Ir(III) complexes.

Arylamines are known to form covalent-DNA adducts upon metabolic activation. These covalent adducts adopt different conformational attributes, viz., major groove (B), stacked (S), and minor groove (W), and lead to different types of mutations.

Selective Recognition of Conformation-Specific Arylamine-DNA Adduct in Frameshift Model by [Ru(phen)(dppz)].

Arylamine modification of guanine base at the G position in the I sequence (-GGCGCC-) causes a frameshift mutation. Polymerase and F NMR studies have shown that the next flanking base at the 3' position to the G adduct modulates the mutational outcome because of its different conformations. Here, we have studied the interaction of the 16-mer I sequence (5'-CTCTCGGCCXATCAC-3') (G = -acetyl-2-aminofluorene (AAF)-dG and X is either C or T) with [Ru(phen)(dppz)] (phen = 1,10-phenanthroline and dppz = dipyrido[3,2-:2',3'-]phenazine).

Influence of galactosidases on glycosaminoglycan removal Vis-à-Vis opening up of skin matrix to enable complete rehydration.

Enzymatic interventions in animal skin processing are increasingly being considered as safe and benign technology options due to the reduction and replacement of potential harmful chemicals. In this study, galactosidases have been employed for rehydration of preserved skins and hides to improve the process efficiency and minimize hazardous sodium sulfide. The purpose of rehydration is to ensure the skin is hydrated uniformly to facilitate subsequent physico-chemical processes of leather making.

Unprecedented formation of palladium(II)-pyrazole based thiourea from chromone thiosemicarbazone and [PdCl(PPh)]: Interaction with biomolecules and apoptosis through mitochondrial signaling pathway.

Two novel pyrazole based thiourea palladium(II) complexes, [PdCl(PPh)(CHNOS-pz)] (1) and [PdCl(PPh)(CHNOS-pz)] (2) [pz = pyrazole (CHN)] have been obtained unexpectedly from chromone thiosemicarbazones (L1 and L2) and [PdCl(PPh)]. The compounds have been fully characterized by physicochemical studies. The single crystal X-ray diffraction and spectral studies revealed square planar geometry for the complexes.

Topical administration of pullulan gel accelerates skin tissue regeneration by enhancing collagen synthesis and wound contraction in rats.

Here, we have studied the efficacy of pullulan gel on wound healing by performing biochemical, biophysical and histological investigations. A 2 cm open excision wound was made on the dorsum of the rats and topically treated with 500 μL of pullulan gel. The control group was left untreated.

Fabrication and characterization of herbal drug enriched Guar galactomannan based nanofibrous mats seeded with GMSC's for wound healing applications.

Electrospun nanofibrous Guar gum/PVA based scaffold matrix incorporated with standardized extracts of four traditional medicinal plants of wound healing repute namely - Acalypha indica (A.i), Aristolochia bracteolata (A.b), Lawsonia inermis (L.

Silica microsphere-resorcinol composite embedded collagen scaffolds impart scar-less healing of chronic infected burns in type-I diabetic and non-diabetic rats.

The existence of diabetes and microbial infection in burn wounds makes the healing process more complex. Herein, we synthesize a collagen based hybrid scaffold incorporated with a silica-resorcinol composite and cross-linked with an oxidized fenugreek seed polysaccharide to stimulate scar-less healing in chronic wounds with type-I diabetes and microbial infection. The spectroscopic analyses of the hybrid scaffolds reveal the chemical and structural integrity of collagen.

Co-delivery of Diverse Therapeutic Compounds Using PEG-PLGA Nanoparticle Cargo against Drug-Resistant Bacteria: An Improved Anti-biofilm Strategy.

Controlling biofilms of bacteria is a challenging aspect because of their drug-resistance potentials against a range of antibiotics, demanding the development of active anti-biofilm agents. Rutin (R), a natural antioxidant, and benzamide (B), a synthetic antibacterial agent, have several pharmacological and antibacterial abilities. Herein, we developed PEG-PLGA NPs that synergistically carried rutin and benzamide as drug candidates, while displaying therapeutic and anti-biofilm  functions.

Design and fabrication of electrospun SBA-15-incorporated PVA with curcumin: a biomimetic nanoscaffold for skin tissue engineering.

Fabricating and designing a scaffold is a complex and highly challenging process in the current scenario. The present study deals with the design and fabrication of electrospun Santa Barbara Amorphous (SBA)-15-incorporated polyvinyl alcohol (PVA) with curcumin, which can be used as a biomimetic nanoscaffold for skin tissue engineering. Curcumin was selected due to its effective anti-microbial and anti-inflammatory properties.

Polymethyl methacrylate (PMMA) grafted collagen scaffold reinforced by PdO-TiO nanocomposites.

In the past few decades, the design and fabrication of bio-scaffolds exhibiting structural stability in long-term and biocompatibility has received much attention in the field of tissue engineering application. In this direction, we have synthesized different mole ratio of PdO-TiO nanocomposites (1:1, 2:1 and 3:1 of Pd:Ti, size 5-11nm, 7-16 nm and 9-22 nm) through a simple single step sol-gel method. The obtained nanocomposites of different sizes were assimilated into poly (methyl methacrylate) grafted collagen biopolymer (g-PMMA-Collagen), resulting in a PdO-TiO-g-PMMA-Collagen based scaffold.

Collagen stabilization using ionic liquid functionalised cerium oxide nanoparticle.

Nanoparticles owing to their size have a substantial influence on the biological behavior of collagen, thereby opening new channels to unfold the propensity of nanoparticles in terms of collagen stabilization. The present study aims to synthesize and characterize cerium oxide nanoparticles and to investigate their crosslinking efficiency on collagen. Cerium oxide nanoparticles, known biocatalysts, form an effective oxidation system due to their variable oxidation state.

Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells.

The present study is aimed to study and to evaluate the colon cancer targeting efficacy of chitosan-coated-trans-resveratrol (RSV) and ferulic acid (FER) loaded SLNs (solid lipid nanoparticles) that conjugated with folic acid (FA) (C-RSV-FER-FA-SLNs) in suitable models (in vitro). The FA conjugation is performed using co-encapsulation method of stearic acid. Similarly, the prepared SLNs are exhibited better stability even under acidic conditions to exhibit their potentials to use as drug delivery system.

Investigation on pyrolysis and incineration of chrome-tanned solid waste from tanneries for effective treatment and disposal: an experimental study.

Chrome-tanned leather solid wastes (leather finished trimmings (LFT) and chrome shavings (CS)) from tanneries were studied using pyrolysis and incineration. Detailed characterization of CS and LFT indicated higher calorific value of 15.77 MJ/kg and 19.

Efficacy of Recombinant Human Epidermal Growth Factor (Regen-D 150) in Healing Diabetic Foot Ulcers: A Hospital-Based Randomized Controlled Trial.

To validate the efficacy of recombinant human epidermal growth factor (hEGH) in healing diabetic foot ulcers (DFUs) at biochemical and molecular levels. A total of 50 noninfected DFU subjects were recruited for the study and divided into 2 groups based on the treatment application on the subjects. Group 1: DFU subjects treated with hEGH gel-based product called Regen-D 150 (n = 27) and group 2: DFU subjects treated with alternative placebo as the control group (n = 23).

Influence of micelles on protein's denaturation.

To evaluate the role of micelles for protein-surfactant interaction, we have studied the binding modes of serum albumin proteins (human (HSA) and rabbit (RSA)) with anionic-surfactant, sodium dodecyl sulfate (SDS) by using UV-visible, fluorescence, circular dichroism, fluorescence lifetime, atomic force microscopy (AFM) techniques. The study performed with three different pHs (below (4.0), at (4.

An efficient single pot DNA recombination method for protein library generation.

A simple single pot method was developed to generate a library of protein hybrids/chimeras from unrelated parents. This method allows unbiased facile DNA shuffling based recombination between the parents with the introduction of type IIB restriction enzyme, BsaXI, at multiple distinct crossover sites. To assess this methodology, B1 immunoglobulin domain of protein G and top7 were recombined at four sites, yielding 2 (32) possible hybrid proteins.

Bio-reserves inventory-improving substrate management for anaerobic waste treatment in a fast-growing Indian urban city, Chennai.

India is one among the Asia's newly industrialized countries, in which urban centres generate large amount of municipal solid wastes due to the rapid urbanization. To demonstrate urban waste potentials for biogas production by anaerobic digestion, a comprehensive analysis on the availability of organic waste hotspots and its biogas potential for the exemplary case of Chennai, India, was undertaken. The identified hotspots and their biogas potential were plotted with Geographical Information System as thematic maps.

Biokinetics of fed-batch production of poly (3-hydroxybutyrate) using microbial co-culture.

A novel fed-batch strategy based on carbon/nitrogen (C/N) ratio in a microbial co-culture production medium broth was carried out in a biocalorimeter for improved production of poly (3-hydroxybutyrate) (PHB). Shake flask study suggested that the C/N ratio of 10 increased the yield of PHB by 2.8 times.

Protective effect of Nelumbo nucifera (Gaertn.) against HO-induced oxidative stress on H9c2 cardiomyocytes.

Ischemic heart disease (IHD), a severe condition of myocardium facing impediment in the supply of basic needs for cellular metabolism is caused by atherosclerosis. Though statin drugs could control the use of surgery on IHD patients, the complete rehabilitation or prophylaxis can be achieved through herbal-based medicines viz. either in the form of crude extract or pure phytocompounds.

Towards sustainable system configuration for the treatment of fish processing wastewater using bioreactors.

The wastewater generated from fish processing industry contains a credible level of biodegradable proteins and low biodegradable fats, oils, and grease (FOG). The conventional biological treatment of fish processing wastewater (FPWW) containing high concentration of FOG faces the challenges of clogging, hindrance to sedimentation due to the formation of hydrophobic sludge along with lipids, flocculation of sludge with poor activity, dewatering of sludge due to the presence of lipids, and formation of aminated offensive odors. The present investigation employed baffled moving bed biofilm reactor (BMBBR), up-flow anaerobic sludge blanket (UASB) reactor, fluidized immobilized cell carbon oxidation (FICCO) reactor, and chemoautotrophic activated carbon oxidation (CAACO) reactors in series to treat FPWW.

Attenuation of oxidative stress in arthritic rats by ethanolic extract of Albizia procera benth bark through modulation of the expression of inflammatory cytokines.

Ethnopharmacological Relevance: Albizia procera L. (Leguminosae) commonly known as Konda vagai in Tamil, is used for the treatment of stomach and intestinal disorders. A decoction of the bark is prescribed for rheumatism and haemorrhage.

Alkaline protease for an efficacious rehydration of skin matrix by a novel Bacillus crolab MTCC 5468 in sustainable leather production: a green approach.

Objectives: The utilization of biotechnology in leather sector has more extensive in modern years; more particular to proteolytic enzymes and employed in several steps of the leather making such as soaking, dehairing, bating, solid waste management etc. The current study evaluates the performance of alkaline protease from Bacillus crolab MTCC 5468 in single soaking of goat skins matrix by comparing with the conventional multiple soaking processes.

Results: According to the obtained results, the optimum concentration for maximum rehydration of goat skins was accomplished at 1.

Electrospun gelatin-polyethylenimine blend nanofibrous scaffold for biomedical applications.

In this study, gelatin-polyethylenimine blend nanofibers (GEL/PEI) were fabricated via electrospinning with different ratios (9:1, 6:1, 3:1) to integrate the properties of both the polymers for evaluating its biomedical application. From scanning electron microscopy, the average diameter of blend nanofibers (265 ± 0.074 nm to 340 ± 0.