257,100 results match your criteria: "Central Laboratory; Navy General Hospital; Beijing[Affiliation]"

Cell-cell crosstalk in the pathogenesis of acute lung injury and acute respiratory distress syndrome.

Tissue Barriers

January 2025

Sepsis Translational Medicine Key Laboratory of Hunan Province, Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, PR China.

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the result of an exaggerated inflammatory response triggered by a variety of pulmonary and systemic insults. The lung tissues are comprised of a variety of cell types, including alveolar epithelial cells, pulmonary vascular endothelial cells, macrophages, neutrophils, and others. There is mounting evidence that these diverse cell populations within the lung interact to regulate lung inflammation in response to both direct and indirect stimuli.

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Gymnostachyum febrifugum, a less-known ethnomedicinal plant from the Western Ghats of India, is used to treat various diseases and serves as an antioxidant and antibacterial herb. The present study aims to profile the cytotoxic phytochemicals in G. febrifugum roots using GC-MS/MS, in vitro confirmation of cytotoxic potential against breast cancer and an in silico study to understand the mechanism of action.

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Deciphering the colostral-immunity transfer: from mammary gland to neonates small intestine.

Vet Res Commun

January 2025

Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan, China.

Colostrum, the initial mammary secretion produced by various mammals following birth, is a conduit for maternal immunity transfer in diverse mammalian species. Concurrently, many cellular processes are occurring in the neonatal small intestine to prepare it to receive molecular signals from a superfood essential for the neonate's health and development. During the prepartum colostrum secretion, the newborn intestine undergoes transient alterations in the intestinal barrier, primarily regulating immunoglobulin absorption.

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Ferroptosis: A Targetable Vulnerability for Melanoma Treatment.

J Invest Dermatol

January 2025

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, China; Furong Laboratory, Changsha, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China. Electronic address:

Melanoma is a devastating form of skin cancer characterized by a high mutational burden, limited treatment success, and dismal prognosis. Although immunotherapy and targeted therapies have significantly revolutionized melanoma treatment, the majority of patients fail to achieve durable responses, highlighting the urgent need for novel therapeutic strategies. Ferroptosis, an iron-dependent form of regulated cell death driven by the overwhelming accumulation of lipid peroxides, has emerged as a promising therapeutic approach in preclinical melanoma models.

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Extensive homologous recombination safeguards oocyte genome integrity in mammals.

Nucleic Acids Res

January 2025

MOE Key Laboratory of Biosystems Homeostasis and Protection, College of Life Sciences, Zhejiang University, No.866 Yuhangtang Road, 310058, Hangzhou, China.

Meiosis in mammalian oocytes is interrupted by a prolonged arrest at the germinal vesicle stage, during which oocytes have to repair DNA lesions to ensure genome integrity or otherwise undergo apoptosis. The FIRRM/FLIP-FIGNL1 complex dissociates RAD51 from the joint DNA molecules in both homologous recombination (HR) and DNA replication. However, as a type of non-meiotic, non-replicative cells, whether this RAD51-dismantling mechanism regulates genome integrity in oocytes remains elusive.

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A cross-species inducible system for enhanced protein expression and multiplexed metabolic pathway fine-tuning in bacteria.

Nucleic Acids Res

January 2025

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, NO.1800, Lihu avenue, Wuxi 214122, China.

Inducible systems are crucial to metabolic engineering and synthetic biology, enabling organisms that function as biosensors and produce valuable compounds. However, almost all inducible systems are strain-specific, limiting comparative analyses and applications across strains rapidly. This study designed and presented a robust workflow for developing the cross-species inducible system.

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A mobile genetic element-derived primase-polymerase harbors multiple activities implicated in DNA replication and repair.

Nucleic Acids Res

January 2025

State Key Laboratory of Agricultural Microbiology and College of Life Science and Technology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Shizishan Road No.1, Hongshan District, 430070 Wuhan, China.

Primase-polymerases (PrimPols) play divergent functions from DNA replication to DNA repair in all three life domains. In archaea and bacteria, numerous and diverse PPs are encoded by mobile genetic elements (MGEs) and act as the replicases for their MGEs. However, their varying activities and functions are not fully understood.

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Liquid crystal monomers (LCMs), the integral components in the manufacture of digital displays, have engendered environmental concerns due to extensive utilization and intensive emission. Despite their prevalence and ecotoxicity, the LCM impacts on plant growth and agricultural yield remain inadequately understood. In this study, we investigated the specific response mechanisms of tobacco, a pivotal agricultural crop and model plant, to four representative LCMs (2OdF3B, 5CB, 4PiMeOP, 2BzoCP) through integrative molecular and physiological approaches.

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Background: The whitefly Bemisia tabaci is a notorious agricultural pest known for its ability to cause significant crop damage through direct feeding and virus transmission. Its remarkable adaptability and reproductive capacity are linked to its ability to acquire and integrate horizontally transferred genes (HTGs) into its genome. These HTGs increase the physiological and metabolic capacities of this pest, including cholesterol synthesis, which is critical for its survival and reproductive success.

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Attraction of Bactrocera cucurbitae (Coquillett) to selected gut microbiota supernatants: implications for pest control.

Pest Manag Sci

January 2025

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

Background: Bactrocera cucurbitae (Coquillett) is a distructive quarantine insect pest that causes significant economic losses on cucurbit crops. To explore a green control approach, we investigated the behavioral responses of B. cucurbitae larvae and adults to bacterial suspensions, sediments, and supernatants derived from eight gut microbial strains across four distinct genera.

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Glioblastoma (GBM), the most malignant brain tumor with high prevalence, remains highly resistant to the existing immunotherapies due to the significant immunosuppression within tumor microenvironment (TME), predominantly manipulated by M2-phenotypic tumor-associated macrophages (M2-TAMs). Here in this work, an M2-TAMs targeted nano-reprogrammers, MG5-S-IMDQ, is established by decorating the mannose molecule as the targeting moiety as well as the toll-like receptor (TLR) 7/8 agonist, imidazoquinoline (IMDQ) on the dendrimeric nanoscaffold. MG5-S-IMDQ demonstrated an excellent capacity of penetrating the blood-brain barrier (BBB) as well as selectively targeting M2-TAMs in the GBM microenvironment, leading to a phenotype transformation and function restoration of TAMs shown as heightened phagocytic activity toward tumor cells, enhanced cytotoxic effects, and improved tumor antigen cross-presentation capability.

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The chirality of magnons, exhibiting left- and right-handed polarizations analogous to the counterparts of spin-up and spin-down, has emerged as a promising paradigm for information processing. However, the potential of this paradigm is constrained by the controllable excitation and transmission of chiral magnons. Here, the magnon transmission is explored in the GdFeO/NiO/Pt structures.

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To achieve efficient size tuning of printed microstructures on insulating substrates, an integrated process parameter intelligent optimization design framework for alternating current pulse modulation electrohydrodynamic (AC-EHD) printing is proposed for the first time. The framework is comprised of two stages: the construction of a prediction model and the acquisition of process parameters. The first stage employs the elk herd optimizer(EHO)-artificial neural network(ANN) to establish a mapping relationship between printing process parameters and the size of deposited droplets.

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AIE-Active Antibacterial Photosensitizer Disrupting Bacterial Structure: Multicenter Validation against Drug-Resistant Pathogens.

Small Methods

January 2025

Department of Laboratory Medicine, Guangdong Provincial Key Laboratory of Precision Medical Diagnostics, Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors, Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China.

Antimicrobial resistance (AMR) has emerged as a global challenge in treating bacterial infections, creating an urgent need for broad-spectrum antimicrobial agents that can effectively combat multidrug-resistant (MDR) bacteria. Despite advancements in novel antimicrobial agents, many fail to comprehensively cover common resistant bacterial strains or undergo rigorous multi-center validation. Herein, a cationic AIE-active photosensitizers are developed, ITPM, derived from a triphenylamine-pyridine backbone to address the MDR challenge.

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A synergistic photoredox/cobalt/chromium triple catalysis system for regioselective, enantioselective, and diastereoselective 1,4-hydrocarbonation of readily available 1,3-enyne precursors was explored, providing a modular synthetic platform for various trisubstituted axially chiral allenes bearing an extra central chirality. The protocol features a broad substrate scope, good functional group tolerance, excellent selectivity, and mild reaction conditions. Furthermore, a possible reaction mechanism is proposed based on numerous control experiments and density functional theory calculations.

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SOX9 encodes an SRY-related transcription factor critical for chondrogenesis and sex determination among other processes. Loss-of-function variants cause campomelic dysplasia and Pierre Robin Sequence, while both gain- and loss-of-function variants cause disorders of sex development. SOX9 has also been linked to scoliosis and cancers, but variants are undetermined.

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Advancement of the Dragon Heart 7-Series for Pediatric Patients With Heart Failure.

Artif Organs

January 2025

BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA.

Background: Safe and effective pediatric blood pumps continue to lag far behind those developed for adults. To address this growing unmet clinical need, we are developing a hybrid, continuous-flow, magnetically levitated, pediatric total artificial heart (TAH). Our hybrid TAH design, the Dragon Heart (DH), integrates both an axial flow and centrifugal flow blood pump within a single, compact housing.

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Diabetic macular edema (DME) is a significant cause of vision loss. The development of peripheral non-perfusion (PNP) might be associated with the natural course, severity, and treatment of DME. The present study seeks to understand the predictive power of central macular changes and clinico-demographic features for PNP in patients with clinically significant DME.

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With the digital transformation of the manufacturing industry, data monitoring and collecting in the manufacturing process become essential. Pointer meter reading recognition (PMRR) is a key element in data monitoring throughout the manufacturing process. However, existing PMRR methods have low accuracy and insufficient robustness due to issues such as blur, uneven illumination, tilt, and complex backgrounds in meter images.

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Drones are extensively utilized in both military and social development processes. Eliminating the reliance of drone positioning systems on GNSS and enhancing the accuracy of the positioning systems is of significant research value. This paper presents a novel approach that employs a real-scene 3D model and image point cloud reconstruction technology for the autonomous positioning of drones and attains high positioning accuracy.

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Study on Long-Term Temperature Variation Characteristics of Concrete Bridge Tower Cracks Based on Deep Learning.

Sensors (Basel)

January 2025

Key Laboratory of Concrete and Pre-Stressed Concrete Structures of the Ministry of Education, Southeast University, Nanjing 210096, China.

Monitoring existing cracks is a critical component of structural health monitoring in bridges, as temperature fluctuations significantly influence crack development. The study of the Huai'an Bridge indicated that concrete cracks predominantly occur near the central tower, primarily due to temperature variations between the inner and outer surfaces. This research aims to develop a deep learning model utilizing Long Short-Term Memory (LSTM) neural networks to predict crack depth based on the thermal variations experienced by the main tower.

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Bridge expansion joints are critical components that accommodate the movement of a bridge caused by temperature fluctuations, concrete shrinkage, and vehicular loads. Analyzing the spatiotemporal deformation of these expansion joints is essential for monitoring bridge safety. This study investigates the deformation characteristics of Hongtang Bridge in Fuzhou, China, using synthetic aperture radar interferometry (InSAR).

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Article Synopsis
  • The study examines how deep learning can compare gait cycle time series from healthy children assessed in two different labs using similar protocols.
  • Researchers used a ResNet-based model that effectively identified the source of each dataset with high accuracy by analyzing various gait parameters.
  • The findings highlight the need for standardized protocols and effective data pre-processing to improve the consistency and applicability of machine learning models in clinical environments.
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To address the issue of safe, orderly, and efficient operation for unmanned vehicles within the apron area in the future, a hardware framework of aircraft-vehicle-airfield collaboration and a trajectory planning method for unmanned vehicles on the apron were proposed. As for the vehicle-airfield perspective, a collaboration mechanism between flight support tasks and unmanned vehicle departure movement was constructed. As for the latter, a control mechanism was established for the right-of-way control of the apron.

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Lens-Free On-Chip Quantitative Phase Microscopy for Large Phase Objects Based on a Biplane Phase Retrieval Method.

Sensors (Basel)

December 2024

Smart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

Lens-free on-chip microscopy (LFOCM) is a powerful computational imaging technology that combines high-throughput capabilities with cost efficiency. However, in LFOCM, the phase recovered by iterative phase retrieval techniques is generally wrapped into the range of -π to π, necessitating phase unwrapping to recover absolute phase distributions. Moreover, this unwrapping process is prone to errors, particularly in areas with large phase gradients or low spatial sampling, due to the absence of reliable initial guesses.

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