Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease.

Introduction: The purpose of the present study was to study the concept of aspirin resistance or non-responsiveness by investigating the response to long-term aspirin therapy in patients with a former acute myocardial infarction (AMI).

Materials And Methods: Patients with an AMI (n=202) randomly assigned to aspirin 160 mg/day (n=71), aspirin 75 mg/day and warfarin (INR 2.0-2.

The phenotype in Norwegian patients with Bardet-Biedl syndrome with mutations in the BBS4 gene.

Objective: To describe the phenotype of the Bardet-Biedl syndrome in patients with mutations in the BBS4 gene.

Methods: We examined 3 pairs of siblings with Bardet-Biedl syndrome in whom 3 different mutations in the BBS4 gene were detected, 2 of which were homozygous for the mutation.

Results: All patients had an increased body mass index.

Treatment of menorrhagia with the levonorgestrel intrauterine system versus endometrial resection.

Objective: Treatment of menorrhagia with levonorgestrel intrauterine system (LNG IUS) and transcervical resection.

Design: An open, therapeutic, randomized study.

Setting: Central county hospital specializing in hysteroscopy.

Rieger syndrome is associated with PAX6 deletion.

Purpose: Rieger syndrome is an autosomal dominant condition defined by anterior segment dysgenesis in combination with facial, dental, skeletal and umbilical abnormalities. To date Rieger syndrome has been associated with mutations in the PITX2 gene at chromosome 4q25 and a second locus has been found at chromosome 13q14.

Methods: We describe a Rieger syndrome case with all the typical dysmorphic features and the molecular genetic finding by use of FISH analysis of the PAX6 gene.

The medium and long-term efficacy of primary argon laser trabeculoplasty in avoiding topical medication in open angle glaucoma.

Purpose: To study the medium and long-term efficacy of primary argon laser trabeculoplasty in open angle glaucoma with especial emphasis on avoidance of additional medical therapy.

Methods: Records of 168 patients with chronic open angle glaucoma or pseudoexfoliation glaucoma who underwent primary argon laser trabeculoplasty between 1987 and 1995 were studied retrospectively (duration of follow-up 1-8 years, mean 4.1 years).

Fluid balance during hysteroscopic surgery.

Absorption of irrigating solution may involve serious complications during hysteroscopic surgery. This absorption occurs mainly into the vessels opened during the procedure. Careful perioperative monitoring of the deficit of collected irrigating medium during transcervical surgery is mandatory.

Intrafamilial variation of the phenotype in Bardet-Biedl syndrome.

Aims: To describe the variation of the phenotype within families with several individuals with Bardet-Biedl syndrome.

Methods: The phenotypes of affected siblings in 11 Scandinavian families with two or more members who had at least three of the features: retinal dystrophy, polydactyly, obesity, hypogenitalism, and mental retardation, were compared [corrected]. Individuals without retinal dystrophy were excluded.

Full-field electroretinograms in individuals with the Laurence-Mood-Bardet-Biedl syndrome.

Purpose: To evaluate rod and cone function in individuals with the Laurence-Moon-Bardet-Biedl syndrome.

Methods: We obtained a full-field electroretinograms in 36 patients. If responses less than 10 microV were recorded with single white flashes a special techniques with narrow band filter and computer averaging was used.

Ocular findings in the Laurence-Moon-Bardet-Biedl syndrome.

Purpose: To improve the description of the ocular part of the Laurence-Moon-Bardet-Biedl syndrome.

Methods: We examined 44 Scandinavian individuals who all had retinal dystrophy plus at least 2 more of the traditional cardinal signs of the syndrome: obesity, hypogenitalism, polydactyly and mental retardation.

Results: Full-field electroretinograms were obtained in 36 of the individuals and were abnormal in all.

The relationship between preoperative endometrial thickness, the anteroposterior diameter of the uterus and clinical outcome following transcervical resection of the endometrium.

The objective of this study was to identify whether the endometrial thickness, or the anteroposterior diameter of the uterus as assessed by transvaginal ultrasonography (TVS), could be used to predict the clinical outcome following transcervical resection of the endometrium (TCRE). An open observational trial was carried out, involving 195 consecutive patients undergoing TCRE, 188 of whom completed follow-up. The patients were examined by TVS preoperatively, and then 6 weeks, 6 months and 1 year following TCRE.

Hormone replacement therapy after transcervical resection of the endometrium.

Objective: To determine if women who have undergone transcervical resection of the endometrium can be treated safely with estrogens alone.

Methods: Sixty-two postmenopausal women who had undergone endometrial resection were recruited into a double-blind, randomized study. Twenty-one had menopausal symptoms at the primary operation and were recruited at the time of the surgery, and 38 were recruited an average of 20 months (range 8-42) after the primary endometrial resection and underwent a second resection to remove any residual endometrium before entering the study.

The cause of death in Laurence-Moon-Bardet-Biedl syndrome.

The certificates of death of 14 deceased patients with Laurence-Moon-Bardet-Biedl (LMBB) syndrome, in which retinal dystrophy is dominant feature, were review. Death occurred at a considerably younger age than in the general population. Renal disease was noted as primary or contributing cause of death in 7 cases with the diagnoses: cyst of the kidney, renal sclerosis, renal failure, proteinuria, renal disease unspecified and malignant hypertension with renal involvement.

The incidence of fallopian tube patency after transcervical resection of the endometrium including rollerball diathermy to the tubal ostia.

Objective: To evaluate the incidence of tubal patency as well as the shape of the endometrial cavity after transcervical resection of the endometrium.

Design: An open observational trial.

Setting: The obstetrics and gynecology unit at a district hospital in Norway.