Sleep duration and sleep complaints and risk of myocardial infarction in middle-aged men and women from the general population: the MONICA/KORA Augsburg cohort study.

Study Objectives: To examine gender-specific associations between sleep duration and sleep complaints and incident myocardial infarction (MI).

Design: Cohort study.

Setting: A representative population sample of middle-aged subjects in Germany.

Sex-specific determinants of left ventricular mass in pre-diabetic and type 2 diabetic subjects: the Augsburg Diabetes Family Study.

Objective: Obesity and hypertension are regarded as the most important determinants of left ventricular mass in the community. Little is known about sex-specific influences of obesity, hypertension, and other risk factors on left ventricular mass in pre-diabetic or diabetic subjects.

Research Design And Methods: We examined how body composition, blood pressure, and other factors are related to left ventricular structure in elderly subjects (mean age 62 years, 88% of women postmenopausal) with pre-diabetes (impaired fasting glucose or impaired glucose tolerance; n = 112) and diabetes with (n = 181) and without (n = 213) overt cardiovascular disease (CVD).

Beta-blocker use and risk of fractures in men and women from the general population: the MONICA/KORA Augsburg cohort study.

Unlabelled: Use of beta-blockers is associated with a reduced risk of fractures in middle-aged and older subjects from the general population.

Introduction: The present prospective population-based study investigated the association between use of beta-blockers and incidence of any fracture.

Methods: The study was based on 1,793 persons 55 to 74 years of age who participated in one of the three MONICA Augsburg surveys between 1984 and 1995.

Influence of antihypertensive therapy and blood pressure control on left ventricular geometry and function in subjects with type II diabetes: The Augsburg Diabetes Family Study.

Cross-sectional data often fail to show beneficial effects of antihypertensive therapy in patients with hypertension. We, therefore, examined the influence of hypertension control on left ventricular (LV) structure in diabetic persons separated into those having and not having any known cardiovascular disease (CVD) symptoms. The study population consisted of 394 subjects with type II diabetes.

Chronic kidney disease and risk of incident myocardial infarction and all-cause and cardiovascular disease mortality in middle-aged men and women from the general population.

Aims: Chronic kidney disease (CKD) was found to be an independent risk factor for all-cause mortality as well as adverse cardiovascular disease (CVD) events in high-risk populations. Findings from population-based studies are scarce and inconsistent. We investigated the gender-specific association of CKD with all-cause mortality, cardiovascular mortality, and incident myocardial infarction (MI) in a population-based cohort.

Regional disparities of hypertension prevalence and management within Germany.

Objective: To investigate regional variations in the prevalence and management of hypertension in two communities in the north-east and the south-west of Germany.

Study Setting: Two population-based surveys of men and women aged 25-74 years, using a common standardized protocol: the Study of Health in Pomerania (SHIP; 3744 participants) and the Kooperative Gesundheitsforschung in der Region Augsburg (KORA; 4224 participants).

Main Outcome Measures: Comparison of SHIP and KORA with regard to mean systolic (SBP) and diastolic blood pressure (DBP), prevalence of hypertension, percentage of awareness, treatment and control of hypertension in the community, by age and sex.

Serum gamma-glutamyltransferase is a predictor of incident coronary events in apparently healthy men from the general population.

Objective: To investigate whether serum gamma-glutamyltransferase (GGT) is an independent predictor for incident coronary events in initially healthy men from the general population.

Methods And Results: The study was based on 1878 men (aged 25-64 years) who participated in the first MONICA Augsburg survey 1984/1985, and who were free of coronary heart disease at baseline. Up to 2002 a total of 150 incident acute coronary events occurred.

Postload plasma glucose and 30-year mortality among nondiabetic middle-aged men from the general population: the ERFORT Study.

Purpose: The purpose of the study is to examine for the first time the association between 1-hour postload plasma glucose levels and known diabetes and 30-year total mortality.

Methods: The population-based Erfurt Male Cohort Study of 1160 men aged 40 to 59 years was carried out between September 1973 and August 1975. A 1-hour postload venous blood sample was obtained after an oral glucose tolerance test in all nondiabetic subjects.

Admission blood glucose and adverse outcomes in non-diabetic patients with myocardial infarction in the reperfusion era.

Aims: To investigate the association between admission blood glucose levels and adverse outcomes after an incident acute myocardial infarction across a broad range of glucose levels in non-diabetic patients treated with modern therapy.

Methods: The relationship between admission blood glucose and 28-day case fatality was studied in 1348 consecutively hospitalized patients with a first-ever myocardial infarction between January 1998 and December 2002 recruited from a population-based myocardial infarction registry.

Results: Patients were divided into quartiles on the basis of admission glucose level.

Serum gamma-glutamyltransferase and risk of type 2 diabetes mellitus in men and women from the general population.

Objectives: To examine gender-specific associations between gamma-glutamyltransferase (GGT) and incident type 2 diabetes mellitus in a representative population-based sample in Germany.

Design: Prospective population-based study.

Methods: The study was based on 1851 men and 1836 women (aged 25-64 years) who participated in the first Monitoring Trends and Determinants on Cardiovascular Diseases (MONICA) Augsburg Survey 1984/1985, and who were free of diabetes at baseline.

Prognostic value of apolipoprotein B and A-I in the prediction of myocardial infarction in middle-aged men and women: results from the MONICA/KORA Augsburg cohort study.

Aims: To investigate the association between apolipoprotein B (apoB), A-I (apoA-I), the apoB/apoA-I ratio, and the incidence of coronary events.

Methods And Results: Analysis included 1414 men and 1436 women aged 35-64 years without a prior coronary event who participated in the population-based MONICA Augsburg survey 1984-85 (median followed-up period 13 years). Incidence of fatal and non-fatal myocardial infarction, and sudden cardiac death was assessed using data of the MONICA/KORA Augsburg coronary event registry.

The relationship between body weight and health care among German women.

Objective: To investigate the relationship between body weight and the use of health care services among women from southern Germany.

Research Methods And Procedures: Data were drawn from the 1994 to 1995 Monitoring of Trends and Determinants in Cardiovascular Disease Augsburg survey, covering a population-representative sample of women 25 to 74 years old (n = 2301). Logistic regression models were used to calculate odds ratios (ORs) for the use of medical services by women with overweight (BMI 25.