Effects of hyperthermia and acidosis on mitochondrial oxidative phosphorylation.

The intracellular environment of skeletal muscle can develop pronounced hyperthermia and acidosis during strenuous exercise, and these alterations in the typical intracellular conditions have been shown to alter mitochondrial respiration. However, the impact of these conditions on ATP synthesis is poorly understood. We used Thoroughbred racehorses to test the hypothesis that both hyperthermia and acidosis decrease the rate of ATP synthesis, but that athletic conditioning mitigates this loss of phosphorylation capacity.

The impact of cavaletti height on dogs' walking speed and its implications for ground reaction forces.

Objective: The objective of this study was to investigate the effects of cavaletti pole height on temporospatial (TPS) and ground reaction force (GRF) variables as compared to a walking gait in healthy dogs.

Animals: A total of 25 client-owned dogs were included in this study.

Procedures: This study used client-owned dogs to explore the effects of cavaletti pole height on TPS and GRF variables.

The use of platelet rich plasma in the treatment of degenerative joint disease in cats: an exploratory case series.

Objective: To evaluate the effectiveness of intra-articular autologous Platelet Rich Plasma (PRP) in managing Degenerative Joint Disease (DJD) in cats.

Design: Prospective pilot clinical trial.

Methods: Six domestic cats with clinically and radiographically diagnosed DJD received intra-articular injections of autologous PRP.

Untargeted metabolomic profiles reveal widespread metabolic perturbations and identify candidate biomarkers in aminoaciduric canine hypoaminoacidemic hepatopathy syndrome.

Objective: To identify metabolites and metabolic pathways affected in dogs with aminoaciduric canine hypoaminoacidemic hepatopathy syndrome (ACHES) compared to healthy control (CON) dogs of similar ages and breeds. To improve our understanding of ACHES pathophysiology and identify novel candidate biomarkers associated with ACHES.

Animals: A prospective case-control study.

Retrospective study of aldosterone and progesterone secreting adrenal tumors in 10 cats.

Background: Primary hyperaldosteronism caused by adrenal neoplasia has been well described in cats. Multiple corticosteroid abnormalities occur in a subset of affected cats, but characterizations of this syndrome are limited to several case reports.

Objectives: To describe a series of cats with adrenal tumors secreting aldosterone and additional corticosteroids.

Effects of topical flurbiprofen sodium, diclofenac sodium, ketorolac tromethamine and benzalkonium chloride on corneal sensitivity in normal dogs.

To evaluate corneal sensitivity by using the Cochet-Bonnet® esthesiometer in normal canine eyes at different time points following instillation of three different topical non-steroidal anti-inflammatory drugs (flurbiprofen sodium 0.03%, diclofenac sodium 0.1% and ketorolac tromethamine 0.

Tolerability of toceranib phosphate (Palladia) when used in conjunction with other therapies in 35 cats with feline oral squamous cell carcinoma: 2009-2013.

Objectives Squamous cell carcinoma (SCC) is the most common oral tumor in cats and typically carries a poor prognosis with current treatment options. The objective of this study was to evaluate the toxicity of toceranib phosphate (Palladia; Pfizer) in cats with oral SCC in combination with other treatment modalities. Methods In this study, 35 cats were retrospectively evaluated to determine toxicity when treated with toceranib in combination with other treatment modalities.

Why Psychology Matters in Veterinary Medicine.

As companion animals become more central to individuals and families, there are countless ways that veterinary medical practice can benefit from understanding human psychology. This article highlights how insights from the fields of health psychology and behavioral medicine might hold the potential to improve veterinary practice. We focus on key areas of care for companion animals that are integrally linked to their human caregivers׳ psychological reactions and behavior, including health maintenance, managing illness, and end-of-life care.

Proteinuria in dogs and cats.

Proteinuria is defined as the presence of protein in the urine. Normally, circulating serum proteins are blocked by the glomerulus due to size and/or charge. Any small proteins that pass through a healthy glomerulus are reabsorbed by the renal tubules or broken down by renal tubular epithelial cells.