Prognostic Value of Epicardial Adipose Tissue in Heart Failure With Mid-Range and Preserved Ejection Fraction: A Multicenter Study.

Background: Epicardial adipose tissue (EAT) accumulation is thought to play a role in the pathophysiology of heart failure (HF) with mid-range ejection fraction and HF with preserved ejection fraction, but its effect on outcome is unknown.

Methods And Results: A total of 692 patients with HF with mid-range ejection fraction or HF with preserved ejection fraction who underwent cardiovascular magnetic resonance at 2 medical centers in China between October 2016 and October 2022 were included in this study. EAT volume and extracellular volume were calculated using cardiovascular magnetic resonance.

Predictive value of IL-10 and GFPA for postoperative prognosis in patients with brain glioma.

Objective: To investigate the prognostic value of interleukin (IL)-10 and glial fibrillary acidic protein (GFPA) in patients with brain glioma following surgery.

Methods: The clinical data of 75 patients with brain glioma (Observation group) who were treated at the Central Hospital Affiliated with Shandong First Medical University were retrospectively analyzed. Additionally, 40 healthy volunteers who underwent physical examination during the same period were selected as the control group.

Serum bisphenol S levels are associated with decreased ovarian reserve function: a single-center study.

Objectives: Bisphenol A (BPA) is a representative environmental estrogen that is known to impair the function of the female reproductive system by affecting steroid hormones. However, not much research has been done on bisphenol S (BPS), which is an analogue of BPA and has been found in humans.

Methods: We retrospectively studied 152 female volunteers at childbearing age who came to the Shandong Provincial Reproductive Medicine Center between January 2018 and January 2023.

Analysis of effectiveness in an artificial intelligent film reading system combined with liquid based cytology examination for cervical cancer screening.

Objective: To explore the effectiveness of combining an artificial intelligence (AI) film reading system with a cervical liquid-based ThinPrep cytology test (TCT) in cervical cancer screening.

Methods: A total of 1200 adult women who underwent cervical cancer screening in the Gynecology Department of The Fifth People's Hospital of Jinan from July 2022 to June 2023 were included in the study. All participants underwent TCT followed by both manual and AI examination.

Advances in the preparation and biological applications of core@shell nanocrystals based on quantum dots and noble metal.

Core/shell structured nanoparticles (NPs) are a novel category of functional materials that have garnered widespread attention due to their advantageous preparation methods, unique characteristics, and multifunctional application prospects, which have shown significant performance in materials chemistry and many other fields, such as electronics, biomedical, pharmaceutical, optics, and catalysis. Although some reviews about core/shell NPs have been published, there is still an intense requirement for an extensive review about the updated literature and new reported core/shell nanomaterials. Colloidal quantum dots (QDs) and noble metal NPs have a very small size, which results in the large surface-to-volume ratio and under-coordinated chemical bonds.

Serum deprivation protein response intervenes in the proliferation, motility, and extracellular matrix production in keloid fibroblasts by blocking the amplification of TGF-β1/SMAD signal cascade via ERK1/2.

Keloid formation has been linked to abnormal fibroblast function, such as excessive proliferation and extracellular matrix (ECM) production. Serum deprivation protein response (SDPR) is a crucial regulator of cellular function under diverse pathological conditions, yet its role in keloid formation remains unknown. The current work investigated the function of SDPR in regulating the proliferation, motility, and ECM production of keloid fibroblasts (KFs), as well as to decipher the mechanisms involved.

Intestinal flora and pregnancy complications: Current insights and future prospects.

Numerous studies have demonstrated the pivotal roles of intestinal microbiota in many physiopathological processes through complex interactions with the host. As a unique period in a woman's lifespan, pregnancy is characterized by changes in hormones, immunity, and metabolism. The gut microbiota also changes during this period and plays a crucial role in maintaining a healthy pregnancy.

[Effects of early debridement and conservative eschar removal followed by wound coverage with acellular dermal matrix in the treatment of children with deep burns].

To explore the effects of early debridement and conservative eschar removal followed by wound coverage with acellular dermal matrix (ADM), i.e., early surgery, in the treatment of children with deep burns.

DEC1 is involved in TGF-β1-induced epithelial-mesenchymal transition of gastric cancer.

DEC1 is a helix-loop-helix (bHLH) transcription factor, whose deregulation has been observed in several tumors. However, the effects of the dysregulation of this gene on epithelial-mesenchymal transition (EMT) are controversial, with its roles in gastric cancer (GC) remaining unclear. In the present study, we focused on the impact of DEC1 on EMT and cell mobility in gastric cancer.

[Application effects of nitrous oxide and oxygen mixed inhalation technology on analgesia and sedation during debridement and dressing change in children with moderate or severe burns].

To investigate the application effects of nitrous oxide and oxygen mixed inhalation technology on analgesia and sedation during debridement and dressing change in children with moderate or severe burns. A retrospective non-randomized contemporary controlled study was conducted. From December 2019 to November 2021, 140 burn children with moderate or severe burns, aged 1 to 3 years, who met the inclusion criteria were admitted to Central Hospital Affiliated to Shandong First Medical University.

Cyclophilin D as a potential therapeutic target of liver ischemia/reperfusion injury by mediating crosstalk between apoptosis and autophagy.

Background: Liver ischemia/reperfusion (I/R) injury is a complex and multifactorial pathophysiological process. It is well recognized that the membrane permeability transition pore (mPTP) opening of mitochondria plays a crucial role in cell death after I/R injury. Cyclophilin D (CypD) is a critical positive regulator of mPTP.

Tumor-derived Immunoglobulin-like transcript 4 facilitates angiogenesis of colorectal cancer.

Current anti-angiogenic therapies have changed the paradigm of treating colorectal cancer (CRC) patients with advanced diseases. However, the clinical response rate is still low at less than 10% due largely to complex angiogenic factors released by tumor cells. Exploring novel mechanisms of tumor angiogenesis and identifying alternative targets for combination therapies are therefore essential to effective inhibition of tumor vascularization and CRC development.

Roles of Krüppel-like factor 6 splice variant 1 in the development, diagnosis, and possible treatment strategies for non-small cell lung cancer.

Krüppel-like factor 6 (KLF6) is a nuclear transcriptional regulator found in mammalian tissue that has been identified as a tumor suppressor gene in several malignancies. As a result of loss of heterozygosity, DNA methylation, and alternative splicing, it is frequently inactivated in various malignancies. Krüppel-like factor 6 splice variant 1 (KLF6-SV1), Krüppel-like factor 6 splice variant 2, and Krüppel-like factor 6 splice variant 3 alternatively spliced isoforms that emerge from a single nucleotide polymorphism in the KLF6 gene.

Effect of changes in the menstrual cycle and age on the signal intensity of amide proton transfer imaging in the normal uterus: a preliminary study.

Purpose: To analyze the effect of changes in the menstrual cycle and age on the signal intensity of amide proton transfer (APT) imaging in normal uterine structures.

Methods: Thirty-one healthy females (age: 21-50 years old) underwent regular pelvic MRI and APT sequences during their menstrual cycle. The APT values of the endometrium, myometrium, and junctional zone were measured.

Dynamic Changes in Gut Microbiome of Ulcerative Colitis: Initial Study from Animal Model.

Background: An animal model of DSS-induced UC has been widely used in basic research, and the dysbiosis of gut microbiome is one of the important pathogenetic mechanisms of DSS-induced UC, but its dynamic changes and correlation with inflammatory factors are not clear yet.

Methods: Clinical signs and tissue damage degree of C57BL/6 ulcerative colitis mice model induced by different concentrations of DSS were compared with that of normal mice, and finally the optimal concentration of DSS was determined. Then we analyzed the sequencing results of gut microbiome and inflammatory factors to determine the dynamic patterns of gut microbiome and their correlation with the inflammatory factors.

The mRNA levels of PPARα, HIF-1α, and VEGF in the liver tissues of rats with alcoholic liver disease.

Objective: To investigate the mRNA levels of peroxisome proliferator-activated receptor α (PPARα), hypoxia-inducible factor-1α (HIF-1α), and vascular endothelial growth factor (VEGF) in the liver tissues of rats with alcoholic liver disease.

Methods: A total of 50 Wistar rats were randomly divided into a 4-week model group ( = 10), an 8-week model group ( = 10), a 12-week model group ( = 10), a 16-week model group ( = 10), and a control group ( = 10). The control group got the same volume of distilled water, and the rats in the model groups were given ethanol to establish alcoholic liver disease model.

The combined detection of autoantibody characteristics in systemic lupus erythematosus.

Objective: To investigate the combined detection of the autoantibody characteristics in systemic lupus erythematosus (SLE).

Methods: 105 SLE patients admitted to our hospital from May 2019 to September 2020 were placed in the SLE examination group (the SE group), 110 patients with rheumatic diseases admitted to our hospital during the same period were placed in the disease control group (the DC group), and 100 healthy people who came to our hospital for physical examinations during the same time period were placed in the healthy control group (the HC group). The SLE patients' clinical data were recorded.