Ultrasound and advanced imaging techniques in prostate cancer diagnosis: A comparative study of mpMRI, TRUS, and PET/CT.

Objective: This study aims to assess and compare the diagnostic performance of three advanced imaging modalities-multiparametric magnetic resonance imaging (mpMRI), transrectal ultrasound (TRUS), and positron emission tomography/computed tomography (PET/CT)-in detecting prostate cancer in patients with elevated PSA levels and abnormal DRE findings.

Methods: A retrospective analysis was conducted on 150 male patients aged 50-75 years with elevated PSA and abnormal DRE. The diagnostic accuracy of each modality was assessed through sensitivity, specificity, and the area under the curve (AUC) to compare performance in detecting clinically significant prostate cancer (Gleason score ≥ 7).