Lutein loaded double-layered polymer nanocarrier modulate HO and CoCl induced oxidative and hypoxia damage and angiogenic markers in ARPE-19 cells.

Lutein plays a crucial role in the protection of retina by diminishing oxidative stress in diabetic retinopathy (DR). However, its poor aqueous solubility, chemical instability and low bioavailability edge its application. Also, beneficial effects of lutein supplementation and lower lutein levels in the serum and retina of DR patients created an interest in nanopreparation.

T-2 toxin induces dermal inflammation and toxicity in mice: The healing potential of menthol.

According to the World Health Organization and the Food and Agricultural Organization of the United Nations, T-2 is one of the most harmful food-toxic chemicals, penetrates intact skin. The current study examined the protective benefits of menthol topical treatment on T-2 toxin-induced cutaneous toxicity in mice. Lesions were observed on the skin of the T-2 toxin-treated groups at 72 and 120 h.

Anti-Inflammatory, Antioxidant Activities, and Phytochemical Characterization of Edible Plants Exerting Synergistic Effects in Human Gastric Epithelial Cells.

Dietary bioactive compounds from natural sources (e.g., herbal medicines, foods) are known to potentially suppress acute or chronic inflammation and promote the effectiveness of treatment to reduce the harmful effects of gastritis alone or in combination.

Role of adipocyte-derived extracellular vesicles during the progression of liver inflammation to hepatocellular carcinoma.

Extracellular vesicles are membrane-bound cargos that vary in size and are stably transported through various bodily fluids. Extracellular vesicles communicate information between the cells and organs. Extracellular vesicles from the diseased cells alter cellular responses of the recipient cells contributing to disease progression.

Eugenol nanoemulsion as bio-fumigant: enhanced insecticidal activity against the rice weevil, adults.

Nanoemulsion is a promising delivery system for delivering the plant bioactive molecules against insect pests. In this study, we aimed to prepare eugenol based nanoemulsions (EL-NE) by ultrasonication method to investigate its fumigant toxicity against adults and to analyse the residual characteristics of eugenol bioactive on the treated grains and beetles. In EL-NE preparations, 1:1 ratio of eugenol: Tween 80 combination with 5 min of ultrasonication at frequency of 10 kHz and 12 W power output was determined as optimal.

Influence of milk fat on the physicochemical property of nanoencapsulated curcumin and enhancement of its biological properties thereof.

Unlabelled: Curcumin, bioactive from turmeric , has been known for its therapeutic properties. However, its lipophilic nature and poor bioavailability are the constraints to harnessing its properties. Encapsulation in nano-size helps to alleviate the constraints and enhance its biological properties due to its higher surface area.

Enhancing translation of science into non-English languages.

Translating scientific findings from English to other native languages is essential to make sure that they can be integrated into timely and informed dialogue with policymakers and a diverse range of audiences who are affected by the science. Here, we present innovative approaches how to enhance access to scientific knowledge in non-English languages.

Convalescent action of menthol against T-2 mycotoxin-induced toxicity: An in vitro study with HaCaT cells.

Only T-2 mycotoxin is emitted as an aerosol and is the most toxic fungal secondary metabolite among mycotoxins. In its clinical condition, the skin is severely irritated and painful due to lesions and alimentary toxic aleukia. Herein, we have assessed various bioactive molecules, viz.

Enabling honey quality and authenticity with NMR and LC-IRMS based platform.

Honey has been known for economically motivated adulteration around the world, because of its high demand and short supply. As consequence increasing honey production using the deliberate addition of sugar syrups while claiming a fictitious origin and diversifying it to increase its value. Generally, honey testing is supervised by a set of guidelines and quality parameters to ensure its quality and authenticity.

Lactobacillus fermentum MCC2760 abrogate high-fat induced perturbations in the enterohepatic circulation of bile acids in rats.

Aim: This study in hyperlipidemic rats elucidated the effect of Lactobacillus fermentum MCC2760 on intestinal bile acid (BA) uptake, hepatic BA synthesis, and enterohepatic BA transporters.

Main Methods: Diets rich in saturated fatty acids [coconut oil (CO)] and omega-6 fatty acids [sunflower oil (SFO)] at 25 g fat/100 g diet were fed to rats with or without MCC2760 (10 cells/kg body weight). After 60 days of feeding, intestinal BA uptake and expression of Asbt, Osta/b mRNA and protein, and hepatic expression of Ntcp, Bsep, Cyp7a1, Fxr, Shp, Lrh-1, and Hnf4a mRNA were measured.

Nanofabrication of cobalt-tellurium using Allium sativum extract and its protective efficacy against HO-induced oxidative damage in HaCaT cells.

Allium sativum (A. sativum)is well known for its therapeutic and culinary uses. Because of their high medicinal properties, the clove extract was selected to synthesize cobalt-tellurium nanoparticles.

NIR Absorbing Aromatic -Ethylene Bridged Hexaphyrins (2.1.1.2.1.1): Synthesis, Characterization, and Protonation Studies.

Judicious syntheses, spectroscopic analyses, and solid state structural evidence of two structural variants (with planar geometry) of strongly aromatic hybrid [30] -ethylene bridged hexaphyrins (2.1.1.

Design and Development of Novel Glitazones for Activation of PGC-1α Signaling Via PPAR-γ Agonism: A Promising Therapeutic Approach against Parkinson's Disease.

Herein, we rationally designed and developed two novel glitazones (G1 and G2) to target peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) signaling through peroxisome proliferator-activated receptors (PPAR)-γ agonism as a therapeutic for Parkinson's disease (PD). The synthesized molecules were analyzed by mass spectrometry and NMR spectroscopy. The neuroprotective functionality of the synthesized molecules was assessed by a cell viability assay in lipopolysaccharide-intoxicated SHSY5Y neuroblastoma cell lines.

Molecular insights on PS-PLA lipase activity of human ABHD16B.

The human alpha beta hydrolase domain (ABHD) proteins are ubiquitous and regulate the cellular lipids' anabolic and catabolic processes. The structural aspects for specific biochemical function of many ABHD proteins related to physiological disorders and its link to pathological conditions remain unknown. Here putative human ABHD16B protein was overexpressed in Saccharomyces cerevisiae for its biological activity.

COVID-19: Diabetes Perspective-Pathophysiology and Management.

Recent evidence relating to the impact of COVID-19 on people with diabetes is limited but continues to emerge. COVID-19 pneumonia is a newly identified illness spreading rapidly throughout the world and causes many disabilities and fatal deaths. Over the ensuing 2 years, the indirect effects of the pandemic on healthcare delivery have become prominent, along with the lingering effects of the virus on those directly infected.

Emerging role of non-coding RNAs in resistance to platinum-based anti-cancer agents in lung cancer.

Platinum-based drugs are the first line of therapeutics against many cancers, including lung cancer. Lung cancer is one of the leading causes of cancer-related death worldwide. Platinum-based agents target DNA and prevent replication, and transcription, leading to the inhibition of cell proliferation followed by cellular apoptosis.

Nanomaterials in agriculture for plant health and food safety: a comprehensive review on the current state of agro-nanoscience.

In the modern epoch, nanotechnology took forward the agriculture and food industry with new tools that promise to increase food production sustainably. It also anticipated that it would become a driving economic force shortly. Nanotechnology has the potential to reduce agricultural inputs, enrich the soil by absorbing nutrients, manage plant diseases, and detect diseases.

Evaluation of mechanical, antimicrobial, and antioxidant properties of vanillic acid induced chitosan/poly (vinyl alcohol) active films to prolong the shelf life of green chilli.

Vanillic acid incorporated chitosan/poly(vinyl alcohol) active films were prepared by employing a cost-effective solvent casting technique. FTIR investigation validated the intermolecular interaction and formation of Schiff's base (C=N) between functional groups of vanillic acid, chitosan, and poly(vinyl alcohol). The addition of vanillic acid resulted in homogenous and dense morphology, as confirmed by SEM micrographs.

Utilization of lactobacillus fermented proteins from meat processing wastewaters as a dietary protein source in poultry feed.

The present study aimed to evaluate the impact of fermented meat processing wastewater protein hydrolysate (FWMPH) prepared by fermentation as an alternative protein source on growth performance, serum biochemistry, and hematological parameters of broiler chicks. FWMPH exhibited antioxidant, anti-angiotensin converting enzyme (ACE), and antimicrobial properties. A total of 60 one-day-old Vencobb broiler chicks were divided into five dietary groups on day 8 and a feeding trial was performed for 48 days.

Yeasts originating from fermented foods, their potential as probiotics and therapeutic implication for human health and disease.

Yeasts derived from fermented foods have historically been known for their organoleptic properties, enriching nutritional values, and producing bioactive metabolites with therapeutic potential. In this review, we discuss the yeast flora in fermented foods, their functional aspects in fermentation, as well as their probiotic and biotherapeutic properties. These yeasts have numerous physical and biochemical characteristics, such as larger cells as compared to bacteria, a rigid cell wall composed primarily of glucans and mannans, natural resistance to antibiotics, and the secretion of secondary metabolites that are both pleasing to the consumer and beneficial to the host's health and well-being.

A concise review on oil extraction methods, nutritional and therapeutic role of coconut products.

The coconut palm belongs to the family, which is distinct from other fruits, known for its versatility. Fresh coconut products are valuable for many food preparations owing to their nutritional and flavour properties. For example, tender coconut yields coconut water, a refreshing nutritious drink that provides good nutrients including electrolytes and other interesting compounds.

Isolation, characterization, and utilization of wheat bran protein fraction for food application.

Wheat bran (WB), a low-cost industrial by-product, is a vital source of high-quality proteins, minerals, vitamins, and several bioactive compounds. The present study encompasses the identification of appropriate bran streams of a commercial roller flour mill (CRFM) essentially based on hector liter weight, (HLW), optimization of WB protein isolation process, amino acid characterization, rendering more emphasis on simple water-soluble albumins, having higher commercial viability, and its application in food formulation. Total WB protein was 16.

Prevalence of macrolide-lincosamide-streptogramin resistant lactic acid bacteria isolated from food samples.

Lactic acid bacteria (LAB) being a reservoir of antibiotic resistance genes, tend to disseminate antibiotic resistance that possibly pose a threat to human and animal health. Therefore, the study focuses on the prevalence of macrolide-lincosamide-streptogramin- (MLS) resistance among LAB isolated from various food samples. Diverse phenotypic and genotypic MLS resistance were determined among the LAB species (n = 146) isolated from fermented food products (n = 6) and intestine of food-producing animals (n = 4).

miR-7-5p Antagomir Protects Against Inflammation-Mediated Apoptosis and Lung Injury via Targeting Raf-1 In Vitro and In Vivo.

Exacerbated inflammation and apoptosis are considered upstream events associated with acute lung injury (ALI). microRNAs are critical regulators of genes responsible for inflammation and apoptosis and are considered potential therapeutic targets for ameliorating ALI. This study was undertaken to uncover the role of miR-7-5p in LPS-induced lung injury.