[Evaluation of population's commitment to healthy nutrition and physical culture (by results of the questionnaire)].

One of the main tasks in implementing the foundations of state policy in the field of a healthy lifestyle of the population is the formation of optimal nutritional status and the preservation of public health. In this regard, issues of a comprehensive self-assessment of health by the population are becoming particularly relevant. of the research was to identify the degree of commitment of the population to a healthy lifestyle, including maintaining a balanced diet and the presence of physical activity, as well as the relationship between the respondents' lifestyle and the presence of non-communicable diseases.

The efficiency of Governmental and WFP UN Programs for improvement of nutritional status in Tajik schoolchildren as assessed by dietary intake and hair trace element content.

Background: The objective of the study was to assess hair trace element and mineral content in children undergoing WFP UN and the governmental programs of school nutrition in Tajikistan.

Methods: WFP program included provision or wheat flour fortified with micronutrients including Fe and Zn, and iodized salt, whereas within the governmental program hot meals were provided. A total of 202 children studying in schools that were not (Type 1, n = 100) or were involved in dietary intervention programs (Type 2, n = 102).

Evaluation of influence of the UPOINT-guided multimodal therapy in men with chronic prostatitis/chronic pelvic pain syndrome on dynamic values NIH-CPSI: a prospective, controlled, comparative study.

Background: The aim of this work was to evaluate the influence of UPOINT-guided (Urinary, Psychosocial, Organ-specific, Infection, Neurologic/systemic, Tenderness of skeletal muscles) multimodal therapy in patients with chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS) on the dynamic values of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score.

Patients And Methods: In our study we investigated 110 patients aged 26-68 years with CP/CPPS. We performed digital rectal examination (DRE), pre- and post-massage test (PPMT) urine culture, urine analysis, transrectal ultrasound investigation of prostate, antibiotic susceptibility testing.

Integrating mental health into primary care in Arkhangelsk County, Russia: the Pomor model in psychiatry.

Background: Primary health care is still peripheral in the identification and treatment of mental health and substance use disorders in the Russian Federation. However, the development of primary health services has been given priority. A long-standing collaboration between Arkhangelsk County and northern Norway on mental health service development in Arkhangelsk has promoted the integration of mental health into primary care.

Genetic determinants of dabigatran safety (CES1 gene rs2244613 polymorphism) in the Russian population: multi-ethnic analysis.

This study was aimed to investigate the prevalence of the CES1 gene (c.1168-33A > C, rs2244613) polymorphism among 12 different ethnic groups living in Russia to provide a basis for future clinical studies concerning genetic determinants of dabigatran safety. The study involved 1630 apparently healthy, unrelated, and chronic medication-free volunteers of both genders from 12 different ethnic groups in Russia: 136 Russians, 90 Avars, 50 Dargins, 46 Laks, 120 Kabardians, 112 Balkars, 244 Ossetians, 206 Mari, 204 Mordvinians, 238 Chuvashes, 114 Buryats and 70 Nanays.

[The Analysis of Causes of Dissatisfaction of Patients with Medical Care Based on Appeals of Citizen and Independent Evaluation of Quality of Medical Services by Medical Organizations].

The article presents the main approaches to analysis of the causes of the patients' dissatisfaction with medical care based on the appeals of citizen and independent assessment of medical care quality in medical institutions of various levels. The results of evaluation of web-sites testify good results of functioning of medical institutions. The number of sound complaints of citizen on inadequate medical care services in particular medical organizations continues to be high.

[The Analysis of Oncologic Morbidity as a Function of Perspective Planning of Infrastructure of Regional Radiotherapy Service].

The appropriate application of remote radiotherapy ensures significant increasing of survival rate of oncologic patients. The purpose of study is to determine need of the Moscow region in radiotherapy care of patients with the most frequently detected tumors on the basis of oncologic morbidity data. The calculation of minimal regional need in devices of remote radiotherapy was implemented according particular formula.

[Single nucleotide polymorphisms of the CYP11B2, GNB3 and NOS3 genes in various ethnic groups of arctic zone of yakutia suffering from arterial hypertension].

Objective: Introduction: This article presents the results of a study of the frequencies of single nucleotide polymorphisms of the CYP11B2 -344 T> C genes; GNB3 825 C> T; NOS3 -786 T> C and 894 G> T in different ethnic groups of residents of the Arctic zone of the republic "Sakha" (Yakutia), suffering from essential arterial hypertension. The aim: The aim of this study is to determine the presence of statistically significant differences in the frequencies of the above-mentioned polymorphisms in the studied ethnic groups of people living in the Arctic zone of Yakutia.

Patients And Methods: Materials and methods: The material for the study was whole blood obtained during venipuncture.

Three cases of late syphilitic hepatitis.

The article presents literature data for the last 10 years on specific liver damage. There are three own clinical cases of syphilitic hepatitis, one of them - with a lethal outcome. Attention is drawn to the importance of early diagnosis of syphilitic hepatitis.

[Melatonin and man aging in the European part of the Arctic zone of the Russian Federation.].

The analysis of 6-sulfatoxymelatonin (6-SMT) levels in working-age men (aged 19-69) who live in the European part of the Arctic zone of the Russian Federation is presented. Their urine 6-SMT levels were similar to those of comparison group (residents of Western Siberia). The level of 6-SMT decreased with age and was the lowest in 40-49-year group.

[The Evaluation of the System of Mandatory Medical Insurance by Medical Workers of the Moscow Oblast].

The article considers the results of sociological survey of medical personnel of the Moscow oblast. The purpose of study is to analyze attitude of medical personnel to the system of mandatory medical insurance in modern conditions. The sociological survey carried out according standard methodology using originally developed questionnaire.

[Rare abdominal diseases in emergency surgery].

Treatment of 3 children with rare abdominal diseases are presented in the article: acute gangrenous cholecystitis in newborn, gallbladder torsion, vermiform appendix torsion. The authors recall the existence of such rare diseases, especially in those cases when clinical symptoms of acute surgical abdominal pathology do not fit into the well-known canons. Diagnosis was established intraoperatively in all children that confirms difficult diagnosis of these diseases.

[The Traumatogenic Factors of Life-Style of Rural Population].

The article substantiates actuality of problem, presents study methodology and classification of leading traumatogenic factors of life-style of rural population. The results of medical social monitoring were used as a basis for ranking degree of evidence of traumatogenic factors impacting on population health in rural district. The study established a high level of prevalence of traumatogenic factors in population of rural district.

[Age-related dynamics of the contents of matrix metalloproteinases (MMP-1, -2, -3, -9) and tissue inhibitors of matrix metalloproteinases (TIMP-1, -2, -4) in blood plasma of residents of the European part of the Arctic zone of the Russian Federation.].

Here we present the study of enzymes involved in the regulation of extracellular matrix metabolism. It was the first study of this kind in the European part of the Arctic zone of the Russian Federation (AZRF). The contents of matrix metalloproteinases (MMP-1, -2, -3, -9) and tissue inhibitors of matrix metalloproteinases (TIMP-1, -2, -4) were measured in blood plasma of 91 men in AZRF (67o N) and 14 men in Western Siberia.

Epilepsy after ishemic stroke: is it worth administering anticonvulsants after the first attack?

Objective: Introduction: Epileptic attacks frequency in patients after stroke ranges widely from 3 % up to 60 %. Today many aspects of this problem in post-stroke epilepsy haven't been completely studied, regarding the problem of the time for administering antiepileptic drugs (AEDs). The aim of this study was to define the prognosis of symptomatic epilepsy development after stroke depending on the patients taking AEDs after the first epileptic attack.

[The first experience of TAPP and TEP allohernioplasty in patients with inguinal hernias at CRH].

Aim: To improve the outcomes in patients with inguinal hernias by application of advanced minimally invasive procedures.

Material And Methods: The article describes an experience of 59 laparoscopic allohernioplasties in 48 patients at the central regional hospital. There were bilateral hernias in 11 cases.

Primary microcephaly case from the Karachay-Cherkess Republic poses an additional support for microcephaly and Seckel syndrome spectrum disorders.

Background: Primary microcephaly represents an example of clinically and genetically heterogeneous condition. Here we describe a case of primary microcephaly from the Karachay-Cherkess Republic, which was initially diagnosed with Seckel syndrome.

Case Presentation: Clinical exome sequencing of the proband revealed a novel homozygous single nucleotide deletion in ASPM gene, c.

[Interrelation between the melatonin level and indicators of aging and fibrosis in men in the European part of the Arctic zone of Russian Federation.].

The results of the correlation analysis between the metabolite melatonin - 6-sulfatoxymelatonin (6-SMT) in the urine and the indicators of aging, interstitial fibrosis, the system of antioxidant protection in men in the Arctic are presented. Negative correlation of medium strength between 6-SMT with calendar age, biological age and molecular marker of aging p16INK4a in leukocytes was noted. A relationship of 6-SMT to fibrosis indices was found.

Genetic Polymorphisms of Cytochrome P450 Enzymes and Transport Proteins in a Russian Population and Three Ethnic Groups of Dagestan.

Aim: The objective of this study was to investigate the prevalence of polymorphic markers of the CYP2C19, CYP2C9, CYP2D6, SLCO1B1, and ABCB1 genes among the three ethnic groups in Dagestan and compare it with the carrier frequency of these markers among the Russian population living in Moscow.

Methods: The study involved 186 healthy, unrelated, and chronic medication-free volunteers (53 males and 133 females) of the three ethnic groups in the Dagestan Republic: 46 Laks, 90 Avars, and 50 Dargins. Genotyping was performed using real-time polymerase chain reaction-based methods.

[Age-related dynamics of the main extracellular matrix components in residents of the Russian Arctic].

The main extracellular matrix components in Arctic residents were studied. Northerners had increased levels of total glycosaminoglycans, hyaluronan, and collagen IV in plasma and both general and peptide-bound hydroxyproline in urine, which indicates an accelerated metabolism of the main extracellular matrix components compared with comparison group (residents of Siberia). Age-related remodeling of extracellular matrix in northerners manifested in changing ratio and quantity of its main components.

DEPENDENCE OF HEART RATE IN TERMS OF THE DAILY MONITORING INDICATORS ON THE ACTIVITY OF PATHOLOGICAL PROCESS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.

The article studies the dependence of indicators of daily monitoring of heart rate on the pathological process activity in patients with systemic lupus erythematosus. As a result of examination of 83 patients (71 women and 12 men aged 17 - 68) with the first, second and third levels of disease activity (first, second and third group respectively) it was found that: 1) the average, maximum and minimum heart rate in patients with systemic lupus erythematosus during the day is significantly higher than the comparable figures in healthy individuals and the dependence of the increase of heart rate on the progress of disease activity was demonstrated by the results of the evaluation of minimum heart rate and in patients with the third degree of disease activity; 2) the vast majority of indicators of heart rate in patients with systemic lupus erythematosus, evaluated separately in active and passive periods of the day, were above the comparable indicators in healthy individuals and higher in the active period compared to the passive, with statistical significance of differences in average and maximum heart rate; 3) the regularity of an increase of average, maximum and minimum heart rate with the increase of activity of systemic lupus erythematosus is characteristic of patients with high activity of the disease (third degree) and is more pronounced in passive (night) period.

Diffusion tensor imaging tractography and intraoperative neurophysiological monitoring in surgery of intracranial tumors located near the pyramidal tract.

Background: Practical application of methods for intravital examination of the brain pathways, such as preoperative diffusion tensor imaging (DTI) tractography and intraoperative neurophysiological monitoring, facilitates safer resection of intracranial tumors located near the pyramidal tracts (PTs).

Purpose: The study purpose was to investigate the relationships between intracerebral tumors of different histological nature and the pyramidal tract based on preoperative DTI tractography and various methods of intraoperative neurophysiological monitoring for intraoperative identification of the pyramidal tract, depending on different variants of the topographo-anatomic relationships between the pyramidal fascicle and the tumor.

Material And Methods: The study included 29 patients with supratentorial tumors of a different histological structure.

Possible sexual transmission of Crimean-Congo hemorrhagic fever.

Three cases of family transmission of laboratory-confirmed Crimean-Congo hemorrhagic fever (CCHF) among spouses are reported. These spouses had sexual contact at the end of the incubation period or during the early stage of the mild form of CCHF, without any hemorrhagic symptoms in the first infected spouse. This report demonstrates that sexual contact may represent a real risk of CCHF transmission, even if the patient only experiences mild symptoms.

High prevalence of W1282x mutation in cystic fibrosis patients from Karachay-Cherkessia.

Cystic fibrosis (CF; OMIM #219700) is a common autosomal recessive disease. The spectrum and frequency of CFTR mutations vary significantly in different populations and ethnic groups. A genetic epidemiological study was conducted in the indigenous ethnic group of people known as the Karachais.