Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD.

Soluble molecules of the major histocompatibility complex play an important role in the development of various immune-mediated diseases. However, there is not much information on the participation of these proteins in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of our work was to determine the content of soluble molecules of the major histocompatibility complex of classes I and II (sHLA-I and sHLA-II) in the exhaled breath condensate (EBC) and in the blood serum in patients with moderate to severe COPD during the exacerbation and stable phase.

[Minimally invasive surgery for colorectal cancer in advanced age patients].

Aim: To evaluate the role of laparoscopic surgery for colorectal cancer in advanced age patients.

Material And Methods: 290 patients with colorectal cancer were enrolled including 121 patients with rectal cancer and 169 patients with colon cancer. Main group consisted of 171 patients over 60 years old, control group - 119 patients younger 60 years old.

[Efficacy of video-assisted procedures in advanced age patients with colorectal cancer].

Aim: To assess advisability of video-assisted surgery in advanced age patients with colorectal cancer.

Material And Methods: The study involved 44 patients with large intestine tumors. There were 30 patients with colon cancer aged 78.

[Endoscopic interventions in patients with colorectal cancer: the effect of comorbidities].

Aim: To evaluate endoscopic technologies in treatment of patients with colorectal cancer and severe comorbidities.

Material And Methods: Two groups of patients after endoscopic (group 1, n = 58) and open (group 2, n = 40) surgery were assessed.

Results: Comorbidities were observed in 90.

Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients.

The definition of new markers of local and systemic inflammation of chronic obstructive pulmonary disease (COPD) is one of the priority directions in the study of pathogenesis and diagnostic methods improvement for this disease. We investigated 91 patients with COPD and 21 healthy nonsmokers. The levels of soluble CD25, CD38, CD8, and HLA-I-CD8 molecules in the blood serum and exhaled breath condensate (EBC) in moderate-to-severe COPD patients during exacerbation and stable phase were studied.

[Laparoscopic surgery for colon cancer].

Aim: To assess laparoscopic surgery in treatment of colon cancer patients.

Material And Methods: The results of laparoscopic treatment of patients with colorectal cancer are presented in the article. It was estimated the influence of various clinical parameters including age, gender, comorbidities, tumor localization and stage and complications on laparoscopic management of these patients.

[Intraperitoneal and retromuscular abdominal wall repair using ultra-light and titanium-containing polypropylene mesh (experimental research)].

Aim: To study experimental possibility of light, ultra-light and titanium-containing endoprostheses implantation for postoperative hernias correction.

Material And Methods: Abdominal wall repair was simulated in 72 rabbits. In the first group polypropylene mesh with fibers diameter of 90 microns and surface density of 36 g/m2 was used.