Effects of metoprolol and amiodarone combination on heart rate, myocardial contractility and coronary flow: Study in isolated perfused rat hearts.

Background: Beta-blockers and amiodarone have been used concomitantly to treat arrhythmias associated with congestive heart failure. However, the combination of metoprolol and amiodarone has only been studied restrospectively, and its potential effects in congestive heart failure remain to be properly elucidated in prospective trials.

Objective: The present investigation focused on evaluating the pharmacological interaction between metoprolol and amiodarone in an isolated perfused rat heart preparation.