Ultra-Sensitive Gaseous Styrene and Isoprene Detection with a Ratiometric Fluorescence Probe of Eu(III)-Incorporated UiO-67.

The development of probes for the efficient detection of volatile organic compounds is crucial for both human health protection and environmental monitoring. In this study, we successfully synthesized a ratiometric fluorescent sensing material [Eu-UiO-67 (1:1)], featuring dual-emission fluorescence peaks via a one-pot method. This material demonstrated exceptional ratiometric fluorescence recognition properties for liquid styrene and isoprene, achieving low limit of detections (LODs) of 6.

Shenghui decoction inhibits neuronal cell apoptosis to improve Alzheimer's disease through the PDE4B/cAMP/CREB signaling pathway.

Background: Shenghui Decoction (SHD) is a frequently utilized traditional Chinese medicine formula in clinical settings for addressing cognitive impairment in elderly individuals. Nevertheless, the precise mechanism by which SHD exerts its effects on the most prevalent form of dementia, Alzheimer's disease (AD), remains to be elucidated.

Methods: Temperature-induced transgenic C.

Epigenetic Mechanisms in Osteoporosis: Exploring the Power of mA RNA Modification.

Osteoporosis, recognised as a metabolic disorder, has emerged as a significant burden on global health. Although available treatments have made considerable advancements, they remain inadequately addressed. In recent years, the role of epigenetic mechanisms in skeletal disorders has garnered substantial attention, particularly concerning mA RNA modification.

The Effects of Okra Consumption on Glycemic Parameters and Lipid Profile in Adults: A Systematic Review and Meta-Analysis.

The clinical research findings on the effects of okra consumption on blood glucose and lipids are inconsistent. In this study, we aimed to explore the impact of okra consumption on glycemic parameters and lipid profile in adults, including homeostatic model assessment for insulin resistance (HOMA-IR), glycosylated hemoglobin A1c (HbA1c), fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). To find relevant randomized controlled trials (RCTs), we systemically searched EMBASE, Web of Science, PubMed, Cochrane Library, and Scopus until April 2024.

Research on the correlation between inflammatory bowel disease and depression: A bibliometric analysis.

Background: The aim of this study was to conduct a bibliometric analysis of published studies on the relationship between inflammatory bowel disease (IBD) and depression. The study also aims to identify the major researchers, institutions, and countries and regions in this field to identify current research hotspots.

Methods: The Web of Science Core Database in the Science Citation Index Expanded database was selected as the data source and was searched to obtain relevant literature on IBD and depression.

[Glycoside compounds from Chrysanthemum indicum and their antioxidant activity].

Thirteen glycoside compounds were isolated and purified from 95% ethanol extract of Chrysanthemum indicum by normal and reversed phase silica gels, glucan gel, and high performance liquid chromatography, and their chemical structures were identified by spectroscopic data and physicochemical properties. These compounds were(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-benzodioxole-5-benzofuranpropanol-10-O-β-D-glucopyranoside(1), 4,6,8-decatriynyl-β-D-glucopyranoside(2), 5-(β-D-glucopyranosyloxy)-2-hydroxy benzoic acid methyl ester(3), citrusin C(4), cuminyl β-D-glucopyranoside(5), benzyl-6-[(2E)-2-butenoate]-β-D-glucopyranoside(6), benzyl β-D-glucoside(7), viridoside(8), phenylethyl β-D-glucopyranoside(9), syringaresinol-4'-O-β-D-glucoside(10), pinoresinol-4'-O-β-D-glucoside(11), isoeucommin A(12), and eucommin A(13). Among them, compound 1 was a new compound.

[Genome-wide identification and expression pattern analysis of Eucommia ulmoides Trihelix gene family].

Trihelix transcription factors play important roles in plant light responses, growth and development, and stress responses. However, Trihelix has not yet been reported in Eucommia ulmoides. In this study, bioinformatics methods were used to comprehensively identify and analyze the expression patterns of the Trihelix gene family in E.

Introduced paeoniflorin reduces the main toxicity induced by diosbulbin B, the major toxic compound of L.: involved inhibiting inflammation and ferroptosis.

Rhizoma Dioscoreae Bulbiferae (HYZ) is a widely utilized herb in clinical practice, known for its significant biological activities. However, the associated hepatotoxicity poses limitations to its application. Our previous research indicated that the effective mitigation of HYZ-induced hepatotoxicity through the concoction with Radix Paeoniae Alba medicinal juice involves the incorporation of paeoniflorin (Pae) and a reduction in diosbulbin B (DB), the primary toxic compound in HYZ.

Hydroxytyrosol Alleviates Acute Liver Injury by Inhibiting the TNF-α/PI3K/AKT Signaling Pathway via Targeting TNF-α Signaling.

Acute liver injury (ALI) is an injury to liver tissue caused by viruses, drugs, alcohol, and oxygen deprivation, and is one of the most common and serious clinical disorders. Hydroxytyrosol (HT) is a naturally occurring polyphenolic compound isolated from forsythia and has excellent anti-inflammatory properties. However, the effect and mechanisms of HT in ALI remain unclear.

Enhanced electrochemical aptasensor integrating MoS/CuS-Au and SI-RAFT for dual signal amplification in cTnI detection.

Cardiac troponin I (cTnI) is known to be among the prominent diagnostic bio-marker for acute myocardial infarction (AMI). In this paper, we proposed an electrochemical aptasensor with nanomaterial MoS/CuS-Au as the substrate material and perillaldehyde (PA) as the surface-initiated reversible addition fragmentation chain transfer (SI-RAFT) polymerization monomer by mediating the in-situ deposition of silver metal on the electrode surface for ultrasensitive detection of cTnI. The substrate material MoS/CuS-Au not only accelerated the rate transfer between electron, but also provided more active sites for aptamers introduction.

Berberine-based hypercrosslinked polymer: Advanced solid-phase microextraction for high-throughput analysis of aristolochic acids in environmental water and herbal plants.

In this study, a novel berberine based anion-exchanged hypercrosslinked polymer (BBR-HCPs) was synthesized via Friedel-Crafts alkylation using dimethoxymethane as a cross-linking agent. The proposed BBR-HCPs polymer exhibited excellent adsorption capacities for aristolochic acids (AAs). Moreover, there are various interactions such as hydrophobic, π-π stacking, hydrogen bonding, and electrostatic interactions between BBR-HCPs and AAs.

Chronic hyperglycemia induces hepatocyte pyroptosis via Gα/Gα-associated endoplasmic reticulum stress: Effect of pharmacological intervention.

Aims: Hyperglycemia induces pathophysiological changes. Endoplasmic reticulum (ER) stress with Gα overexpression may promote hepatocyte death. This study investigated whether sustained hyperglycemia triggers ER stress-associated pyroptosis and fibrosis in the liver alongside an overexpression of Gα, and examined the potential link with VEGF-A levels.

Baicalin attenuates corticosterone-induced hippocampal neuronal injury by activating mitophagy in an AMPK-dependent manner.

Defective mitophagy is closely related to the neuronal dysfunction and major depressive disorder (MDD). Our previous study found that baicalin could enhance nip-like protein (NIX)-mediated mitophagy and exhibit antidepressant effects, and predicted that AMPK may be the pharmacological target of baicalin. However, validated experiments are lacking.

Triptolide suppresses melanoma cell growth and through the Src-ERK signaling pathway.

Melanoma is a highly aggressive form of skin cancer with a rapidly increasing incidence. New strategies are urgently needed for treating advanced melanoma which is closely linked to metastasis and often results in death. The Src-ERK signaling axis contributes significantly to both cell growth and metastasis.

Utilizing the superoxide dismutase activity of ceria nanoparticles to endow poly-l-lactic acid bone implants with antitumor function.

Currently, numerous bone tumor patients undergo tumor recurrence after surgical resection, which seriously affects their quality of life. In this study, the ceria (CeO) nanoparticle was added to Poly-L-Lactic Acid (PLLA) bone implants endowing the bone implant with antitumor function. The results showed that the reactive oxygen species increased in U2OS cells while it dropped in HEK293 cells as the CeO content increased.

Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling.

Background: The pathogenesis of depression is largely influenced by dyshomeostasis of neuroinflammation regulated by microglia M1/M2 polarization, and NLRP3 inflammasome acts critical roles in shifting microglia polarization. Kaempferol (Kae), a major flavonoid in edible plants, possesses anti-inflammation and anti-depression capacity, but its underlying cellular and molecular mechanisms of antidepressive effect have not yet fully explored.

Methods: In vivo studies with lipopolysaccharide (LPS)-induced depressive mice were carried out to evaluate antidepressant effect of Kae.

FeO@MXene@PEI aerogel immobilized acetylcholinesterase for inhibitor screening from herbal plants.

Screening of acetylcholinesterase (AChE) inhibitors is a common strategy in drug discovery for treating Alzheimer's disease. Herein, AChE was immobilized onto magnetic polyethyleneimine-based MXene aerogels through both electrostatic interactions and covalent bonds, enabling its application in AChE activity assays and inhibitor screening of herbal plants. The composite was analyzed using a range of techniques, including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), and Zeta potential analysis, to gain insight into its chemical and physical properties.

Proteomic analysis and experimental validation reveal the blood-brain barrier protective of Huanshaodan in the treatment of SAMP8 mouse model of Alzheimer's disease.

Background: Huanshaodan (HSD) is a Chinese Herbal Compound which has a definite clinical effect on Alzheimer's disease (AD), however, the underlying mechanism remains unclear. The aim of this study is to preliminarily reveal the mechanism of HSD in the treatment of AD model of SAMP8 mice.

Methods: Chemical composition of HSD and its drug-containing serum were identified by Q-Orbitrap high resolution liquid mass spectrometry.