Exploiting acquired vulnerability to develop novel treatments for cholangiocarcinoma.

Cholangiocarcinoma (CCA) presents a formidable therapeutic challenge due to its extensive heterogeneity and plasticity, which inevitably lead to acquired resistance to current treatments. However, recent evidence suggests that acquired drug resistance is associated with a fitness cost resulting from the myriad of acquired alterations under the selective pressure of the primary treatment. Consequently, CCA patients with acquired resistance are more susceptible to alternative therapies that are ineffective as monotherapies.

Utilizing the superoxide dismutase activity of ceria nanoparticles to endow poly-l-lactic acid bone implants with antitumor function.

Currently, numerous bone tumor patients undergo tumor recurrence after surgical resection, which seriously affects their quality of life. In this study, the ceria (CeO) nanoparticle was added to Poly-L-Lactic Acid (PLLA) bone implants endowing the bone implant with antitumor function. The results showed that the reactive oxygen species increased in U2OS cells while it dropped in HEK293 cells as the CeO content increased.

Optimal adaptive heuristic algorithm based energy optimization with flexible loads using demand response in smart grid.

Demand response-based load scheduling in smart power grids is currently one of the most important topics in energy optimization. There are several benefits to utility companies and their customers from this strategy. The main goal of this work is to employ a load scheduling controller (LSC) to model and solve the scheduling issue for household appliances.

Tumor-immune hybrid cells evade the immune response and potentiate colorectal cancer metastasis through CTLA4.

Understanding the metastatic cascade is critical for the treatment and prevention of cancer-related death. Within a tumor, immune cells have the capacity to fuse with tumor cells to generate tumor-immune hybrid cells (THCs). THCs are hypothesized to be a subset of cancer cells with the capacity to enter circulation as circulating hybrid cells (CHC) and seed metastases.

Optimal planning and sizing of microgrid cluster for performance enhancement.

Access to electricity is a key indicator of a country's development. In developing nations like Ethiopia, this metric is particularly crucial for assessing progress. Currently, about 45.

Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling.

Background: The pathogenesis of depression is largely influenced by dyshomeostasis of neuroinflammation regulated by microglia M1/M2 polarization, and NLRP3 inflammasome acts critical roles in shifting microglia polarization. Kaempferol (Kae), a major flavonoid in edible plants, possesses anti-inflammation and anti-depression capacity, but its underlying cellular and molecular mechanisms of antidepressive effect have not yet fully explored.

Methods: In vivo studies with lipopolysaccharide (LPS)-induced depressive mice were carried out to evaluate antidepressant effect of Kae.

Stroke and Death Following Carotid Endarterectomy or Carotid Artery Stenting: A Ten Year Nationwide Study in France.

Objective: This retrospective, nationwide cohort study aimed to compare peri-procedural stroke or death within 30 days of the procedure (PPSD30) in patients who underwent carotid endarterectomy (CEA) or carotid stenting (CAS).

Methods: This retrospective cohort study used data from the French hospital database PMSI. All patients who underwent CEA or CAS between 2010 and 2019 in France were included.

FeO@MXene@PEI aerogel immobilized acetylcholinesterase for inhibitor screening from herbal plants.

Screening of acetylcholinesterase (AChE) inhibitors is a common strategy in drug discovery for treating Alzheimer's disease. Herein, AChE was immobilized onto magnetic polyethyleneimine-based MXene aerogels through both electrostatic interactions and covalent bonds, enabling its application in AChE activity assays and inhibitor screening of herbal plants. The composite was analyzed using a range of techniques, including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), and Zeta potential analysis, to gain insight into its chemical and physical properties.

The trends of per-and polyfluoroalkyl substances (pfas) in drinking water systems in Maryland, United States.

Per- and polyfluoroalkyl substances (PFAS) have become a major concern in water quality management because of their persistence in the environment and associated health risks. In Maryland, the diverse water resources and densely populated areas, faces unique challenges culminating from PFAS contamination. This research paper presents a comprehensive overview of PFAS contamination trends in Maryland's drinking water systems across four distinct phases, spanning from 2019 to 2022, it highlights the trends of PFAS contamination, environmental and public health risks, and strategies for effective management.

Does the FARNet neural network algorithm accurately identify Posteroanterior cephalometric landmarks?

Background: We explored whether the feature aggregation and refinement network (FARNet) algorithm accurately identified posteroanterior (PA) cephalometric landmarks.

Methods: We identified 47 landmarks on 1,431 PA cephalograms of which 1,177 were used for training, 117 for validation, and 137 for testing. A FARNet-based artificial intelligence (AI) algorithm automatically detected the landmarks.

Identification of two novel variants, c.-35A>T and c.[-35A>T, 725T>G], in the FUT1 gene in a patient exhibiting the para-Bombay phenotype.

Background: Reduced or absent H antigens on red cells with the (para-)Bombay phenotype can arise from FUT1 gene mutations, impacting the structure and function of 1,2-L-fucosyltransferase 1 (1,2-L-FucT1). Here, we identified the novel mutations in one patient displaying the para-Bombay phenotype and examined the potential molecular mechanisms underlying this phenotype.

Materials And Methods: ABH antigens and antibodies were detected in patient's blood and saliva using serological methods.

Genome sequences of dengue virus serotypes 2, 3, and 4 isolated from adult patients in Thailand.

Here, we present the genome sequences of dengue viruses (DENV) isolated from adult patients in Thailand during 2016-2017: DENV2 (412749), DENV3 (416384), and DENV4 (416709). These sequences provide valuable genetic and evolutionary information for dengue research and antiviral development.

Impact of HHIP gene polymorphisms on phenotypes, serum IL-17 and IL-18 in COPD patients of the Chinese Han population.

Background: Genetic factors, including the Hedgehog Interacting Protein (HHIP) gene, play a crucial role in Chronic Obstructive Pulmonary Disease (COPD) susceptibility. This study examines the association between HHIP gene polymorphisms and COPD susceptibility, phenotypes, and serum IL-17 and IL-18 levels in a Han Chinese population.

Methods: A case-control study was conducted with 300 COPD patients and 300 healthy controls in Chinese Han population.

The Buccal Fat Pad: A Unique Human Anatomical Structure and Rich and Easily Accessible Source of Mesenchymal Stem Cells for Tissue Repair.

Buccal fat pads are biconvex adipose tissue bags that are uniquely found on both sides of the human face along the anterior border of the masseter muscles. Buccal fat pads are important determinants of facial appearance, facilitating gliding movements of facial masticatory and mimetic muscles. Buccal fad pad flaps are used for the repair of oral defects and as a rich and easily accessible source of mesenchymal stem cells.