4,093 results match your criteria: "Center of Innovation[Affiliation]"

The Effect of Wettability on Confinement-Induced Phase Behavior and Storage of Alkane in Nanoporous Media.

Langmuir

November 2024

Center of Innovation for Flow through Porous Media, Department of Energy and Petroleum Engineering, University of Wyoming, Laramie, Wyoming 82071, United States.

The impact of wettability on the confined phase behavior of fluids is paramount for various applications, such as gas storage, carbon dioxide sequestration, and water purification. However, the understanding of the fluid-solid intermolecular interactions in confined systems is still limited and requires further investigation. This work investigates the effect of hydrophilic and hydrophobic nanoporous materials on the adsorption and desorption isotherms of -butane.

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Importance: Food insecurity is associated with numerous adverse health outcomes. Little is known about the prevalence of and risks for food insecurity among veterans identifying as lesbian, gay, bisexual, queer, and similar (LGBQ+), a population facing unique social barriers and medical comorbidities.

Objective: To examine food insecurity and potential risk factors among LGBQ+ veterans.

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Article Synopsis
  • A recent study within the US Veterans Affairs Healthcare System evaluates the effectiveness of the BNT162b2 XBB.1.5-adapted COVID-19 vaccine against JN.1-related healthcare outcomes.
  • The study found that vaccine effectiveness (VE) was significantly lower (24-35%) during JN.1 dominance compared to higher effectiveness (50-61%) during XBB dominance for hospitalization and emergency visits.
  • Results highlight the importance of matching vaccines to circulating strains to enhance public health outcomes from COVID-19 vaccination efforts.
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Trends in and Predictors of Patient Pharmacogenomic Test Uptake in a National Healthcare System.

Genet Med

October 2024

Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.

Purpose: Better understanding patient uptake of pharmacogenomic (PGx) testing may inform its implementation and maximize the benefits that such testing can confer. This study examined patient and provider factors associated with PGx test ordering in a national healthcare system where panel-based testing was implemented as part of routine care.

Methods: We used a retrospective matched cohort design and data from the Veterans Health Administration Corporate Data Warehouse.

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Background: Although a majority of patients in the U.S. receive post-acute care in skilled nursing facilities (SNFs) following hip fracture, large-sample observational studies of analgesic prescribing and use in SNFs have not been possible due to limitations in available data sources.

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Clinician and Practice Characteristics Associated With Support of Office-Based Methadone: Findings From a National Survey.

J Addict Med

October 2024

From the Pain Research, Informatics, Multimorbidities and Education Center of Innovation, VA Connecticut Healthcare System, West Haven, CT (MLS, ACB); Program in Addiction Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT (MLS, DAF, EJE); Section of General Internal Medicine, Yale School of Medicine, New Haven, CT (MLS, ACB, DAF, EJE); Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY (DB, FRL); Division on Substance Use Disorders, New York State Psychiatric Institute, New York, NY (DB, FRL); Consortium on Substance Use and Addiction, Social Science Research Institute, Pennsylvania State University, University Park, PA (BFH); College of Education, Pennsylvania State University, University Park, PA (BFH); American Academy of Addiction Psychiatry, East Providence, RI (KC-W); VA Boston Healthcare System, Boston, MA (MAD); Department of Psychiatry, Boston University Medical Center, Boston, MA (MAD); Addiction Technology Transfer Center Network Coordinating Office, University of Missouri, Kansas City, Kansas City, MO (HH); Division of General Internal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA (PJJ); Center for Health Enhancement Systems Studies, University of Wisconsin, Madison, WI (TM); Department of Emergency Medicine, Yale School of Medicine, New Haven, CT & Yale School of Public Health, New Haven, CT (DAF); Center for Interdisciplinary Research on AIDS, Yale School of Public Health, New Haven, CT (EJE).

Background: Alternative models for methadone delivery outside of federal and state-regulated opioid treatment programs may improve access. We determined factors associated with clinician support for continuing office-based methadone.

Methods: We used data from the electronic Opioid Use Disorder Provider COVID-19 Survey conducted among X-waivered clinicians who were providing outpatient, longitudinal treatment of opioid use disorder (OUD) from July 2020 to August 2020.

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Background And Objectives: Nursing home (NH) staff job dissatisfaction and turnover are associated with lower care quality. However, little is known about the impact of being single on workplace experiences. Guided by the Job Demands-Control-Support Model, we compared job satisfaction, turnover intention, and psychological distress for single and partnered parents working in NHs.

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Background: Since 2013, the Veterans Health Administration (VHA) has advanced a person-centered, Whole Health (WH) System of Care, a shift from a disease-oriented system to one that prioritizes "what matters most" to patients in their lives. Whole Health is predicated on patient-provider interactions marked by a multi-level understanding of health and trusted relationships that promote well-being. Presently, WH implementation has been focused largely in primary care settings, yet the goal is to effect a system-wide transformation of care so that Veterans receive WH across VHA clinical settings, including specialty care.

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Social Disadvantage and Disparities in Chronic Liver Disease: A Systematic Review.

Am J Gastroenterol

October 2024

Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Introduction: Social determinants of health (SDOH) may impact chronic liver disease (CLD) outcomes but are not clearly understood. We conducted a systematic review to describe the associations of SDOH with mortality, hospitalizations, and readmissions among patients with CLD.

Methods: This review was registered (PROSPERO ID: CRD42022346654) and identified articles through MEDLINE, Embase, Cochrane Library, and Scopus databases.

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Background: Advance Care Planning via Group Visits (ACP-GV) is a patient-centered intervention facilitated by a clinician using a group modality to promote healthcare decision-making among veterans. Participants in the group document a "Next Step" to use in planning for their future care needs. The next step may include documentation of preferences in an advance directive, discussing plans with family, or anything else to fulfill their ACP needs.

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Importance: The Medicare Competitive Bidding Program (CBP), a policy that reduced durable medical equipment prices, was implemented starting in 2011. Legislation introduced in 2024 aims to remove supplemental oxygen from the CBP because of concerns that recent decreases in oxygen prescribing are due to lower prices set by the CBP, which may have decreased supply and, in turn, limited oxygen access for patients with chronic lung diseases. However, low-value prescribing of oxygen is also prevalent in practice, and decreased oxygen prescription rates may not have necessarily caused harm.

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Substance use is associated with decreased antiretroviral therapy (ART) adherence among people with HIV (PWH). Adherence plays a significant role in mediating the negative effects of substance use on HIV suppression and is a principal modifiable patient-level factor in improving HIV suppression and reducing ART drug resistance. Understanding substance use and ART adherence, particularly with rapidly changing substance use epidemiology and ART regimens, is vital to improving HIV care.

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Purpose: Social support is a treatment target for individuals with post-traumatic stress disorder (PTSD) but is not systematically assessed in clinical care. This review evaluated the quality of patient-reported social support instruments used in PTSD research to identify candidates for measurement-based care (MBC) with this population.

Method: A systematic review identified all validated measures of social support used in research with traumatized populations after 1990.

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Article Synopsis
  • Esophageal anastomotic fistula (AF) is a common and serious complication after esophagectomy for cancer, typically managed with endoscopic stents.
  • A study analyzed data from 55 patients with AF to investigate healing times and factors affecting them, focusing on hospital stays and stent usage until the fistula closed.
  • Findings revealed that different anastomosis types affected healing durations, with eso-gastric anastomosis patients experiencing longer hospital stays and eso-gastric cervical anastomosis showing prolonged fistula closure, particularly influenced by fistula size and prior radiotherapy treatments.
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Associations Between Patient/Caregiver Trust in Clinicians and Experiences of Healthcare-Based Discrimination.

J Am Board Fam Med

October 2024

From the California University of Science and Medicine, Colton, CA (AK); Social Interventions Research and Evaluation Network, Center for Health and Community, University of California San Francisco, San Francisco, CA (LMG); Department of Family and Community Medicine, University of California San Francisco, San Francisco, CA (LMG, EHDM); Children's HealthWatch, Boston, MA (SEDC); School of Public Health & Chobanian and Avedisian School of Medicine, Boston University, Boston, MA (SEDC); Department of Medicine, University of Massachusetts Chan Medical School, North Worcester, MA (EB); Division of Emergency Medicine, Boston Children's Hospital, Boston, MA (EWF); Department of Pediatrics, Harvard Medical School, Boston, MA (EWF); Center of Innovation in Long Term Services and Supports, VA Providence Healthcare System, Providence, RI (AJC); Department of Family Medicine, Warren Alpert Medical School of Brown University (AJC); Department of Health Services, Policy, and Practice, Brown University School of Public Health (AJC); Section of General Internal Medicine, University of Chicago, Chicago, IL (NJG); Center for Community Health and Health Equity, Brigham and Women's Hospital, Boston, MA (MJO); Department of Medicine, Brigham and Women's Hospital, Boston, MA (CRC).

Background: Higher trust in healthcare providers has been linked to better health outcomes and satisfaction. Lower trust has been associated with healthcare-based discrimination.

Objective: Examine associations between experiences of healthcare discrimination and patients' and caregivers of pediatric patients' trust in providers, and identify factors associated with high trust, including prior experience of healthcare-based social screening.

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Article Synopsis
  • Connected sensor technologies are used to collect and analyze data through advanced methods like machine learning, primarily for improving behavioral and physiological outcomes.
  • This study aims to explore how these technologies can enhance rehabilitation services by providing data that informs care decisions.
  • The research will follow a specific framework to select relevant studies published since 2008, involving adults and connected sensor technologies in rehabilitation contexts, using a systematic review approach to analyze outcomes.
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Article Synopsis
  • Understanding the effects of stopping or reducing medication is essential for making informed deprescribing decisions, balancing intended benefits like reduced adverse drug effects (ADE) against unintended harms like withdrawal events (ADWE).
  • Real-world studies face challenges such as lack of randomization, measurement issues, and the complexities of patient factors, which can affect both outcomes and the decision to deprescribe.
  • Methodological improvements in study design, including larger sample sizes, timely data collection, and better statistical controls for biases, are necessary to enhance the validity of findings in deprescribing research.
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Recent research progresses of bioengineered biliary stents.

Mater Today Bio

December 2024

Department of General Surgery, Sir Run Run Shaw Hospital Affiliated to School of Medicine, Zhejiang University, Hangzhou, 310016, China.

Article Synopsis
  • Bile duct lesions can arise from both benign and malignant conditions, often requiring interventional or surgical treatment, with bioengineered biliary stents emerging as a promising solution.
  • These stents offer significant benefits like excellent biocompatibility and stability, and they can aid in the regeneration of damaged bile ducts by using cell sources and organoids.
  • The review examines the evolution of biliary stent types, their fabrication methods, applications in research and clinical settings, and discusses the challenges still faced in advancing bioengineered stent technology for better treatment outcomes.
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Non-Hispanic Black patients diagnosed with prostate cancer between 2014 and 2019 and treated at a comprehensive cancer center were less likely to use tumor-specific genomic testing compared with non-Hispanic White patients. Disparities in the use of precision oncology technologies should be monitored and addressed to ensure equitable cancer care.

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Prior infection protects against induced hepatic fibrosis.

Front Vet Sci

October 2024

Department of Molecular and Cellular Biology, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX, United States.

Background: Schistosomiasis affects approximately 250 million people worldwide, with 200,000 deaths annually. It has been documented that the granulomatous response to () oviposition is the root cause of progressive liver fibrosis in chronic infection, in 20% of the patients, and can lead to liver cirrhosis and/or liver cancer. The influence of helminths coinfection on schistosomiasis-induced liver pathological alterations remains poorly understood.

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Background: Social risks (individual social and economic conditions) have been implicated as playing a major role in the opioid epidemic and may be more prevalent in the most medically vulnerable patients. However, the extent to which specific social risks and other patient factors are associated with opioid use among high-risk patients has not been comprehensively assessed.

Objective: To identify patient-reported and electronic health record (EHR)-derived demographic, social, behavioral/psychological, and clinical characteristics associated with opioid use in Veterans Affairs (VA) patients at high risk for hospitalization or death.

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Initiation and Persistence of Antipsychotic Medications at Hospital Discharge Among Community-Dwelling Veterans With Dementia.

Am J Geriatr Psychiatry

September 2024

Department of Population Health Sciences (LZ, MSB, SNH), Duke University School of Medicine, Durham, NC; Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT) (SW, MSB, SNH), Durham VA Medical Center, Durham, NC; Division of Geriatrics (SNH), Duke University School of Medicine, Durham, NC.

Objectives: Adults with dementia are frequently prescribed antipsychotic medications despite concerns that risks outweigh benefits. Understanding conditions where antipsychotics are initially prescribed, such as hospitalization, may offer insights into reducing inappropriate use.

Design, Setting, Participants: Retrospective cohort study of community-dwelling veterans with dementia aged ≥68 with VA hospitalizations in 2014, using Veterans Health Administration (VA) and Medicare data.

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Background: Accurate and timely diagnosis of dementia is necessary to allow affected individuals to make informed decisions and access appropriate resources. When dementia goes undetected until a hospitalization or nursing home stay, this could reflect delayed diagnosis or misdiagnosis, and may reflect underlying disparities in healthcare access.

Methods: In this retrospective cohort study, we used 2012-2020 Medicare claims and other administrative data to examine variation in setting of dementia diagnosis among fee-for-service Medicare beneficiaries with an initial claims-based dementia diagnosis in 2016.

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