204 results match your criteria: "Center of Excellence in Biotechnology[Affiliation]"

Article Synopsis
  • * Analysis involved 2,431 cases and 1,265 healthy controls, revealing that individuals with the MTHFR variant had a significantly higher risk for conditions like respiratory distress, recurrent pregnancy loss, and intellectual disabilities.
  • * The MTHFR TT-genotype specifically indicated a high risk of abnormal phenotypes, emphasizing the importance of this genetic variant in neurodevelopmental and other health-related outcomes.
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Article Synopsis
  • The study focuses on the relationship between root architecture and the Gibberellic acid-sensitive (GA-sensitive) Rht genes in wheat, particularly their role in improving drought tolerance and plant growth.
  • Out of 200 wheat genotypes analyzed under normal and osmotic stress conditions, significant differences were found in the number of seminal roots and overall root/shoot growth, indicating that genotypes with GA-sensitive Rht13 gene performed better than those with GA-insensitive Rht1 gene.
  • Specifically, certain genotypes showed enhanced root systems (up to 5 seminal roots) and improved growth metrics under stress, suggesting that the presence of GA-sensitive Rht genes is beneficial for nutrient uptake from deeper soil layers.
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Background: The bZIP transcription factor family, characterized by a bZIP domain, plays vital roles in plant stress responses and development. While this family has been extensively studied in various plant species, its specific functions in Camelina sativa (False Flax) remain underexplored.

Methods And Results: This study identified 71 bZIP transcription factors in C.

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Drought stress poses a critical threat to global crop yields and sustainable agriculture. The GASA genes are recognized for their pivotal role in stress tolerance and plant growth, but little is known about how they function in sunflowers. The investigation aimed to identify and elucidate the role of HaGASA genes in conferring sunflowers with drought tolerance.

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  • - The CRISPR/Cas9 system has been applied to edit specific genes in HD and K326 tobacco cultivars, optimizing the system to target lignin and pectin synthesis genes (Ntab06050 and Ntab0857410).
  • - Eight constructs for lignin-related genes and five for pectin-related genes were created; targeting was guided by identifying PAM sequences for effective editing.
  • - Successful mutations of the targeted genes resulted in mutation frequencies of 6.2% for pectin-related NtabGAUT4 and 9.4% for lignin-related NtabCCoAMT.
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  • - In mid-latitude rice systems, mineral nitrogen fertilizers are crucial but lead to significant nitrogen losses, prompting the need for better soil organic matter management and sustainable practices to improve nitrogen efficiency and crop yields.
  • - A study evaluated the effects of combining mineral urea with organic fertilizers (farmyard manure and poultry compost) on various rice genotypes (NUYT-1 to NUYT-6) at Pakistan's National Agricultural Research Centre.
  • - Results showed that using poultry compost along with mineral urea notably increased nitrogen content in soil and plants, boosted shoot and root growth, and enhanced overall crop productivity, with an optimal N application strategy involving a mix of organic and mineral sources.
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CPSF30, a key polyadenylation factor, also serves as an mA reader, playing a crucial role in determining RNA fate post-transcription. While its homologs mammals are known to be vital for viral replication and immune evasion, the full scope of CPSF30 in plant, particular in viral regulation, remains less explored. Our study demonstrates that CPSF30 significantly facilitates the infection of turnip mosaic virus (TuMV) in , as evidenced by infection experiments on the engineered mutant.

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Chitin is the second most prevalent polysaccharide found in nature, following cellulose. Amino-oligosaccharides, the byproducts of chitin degradation, exhibit favorable biological properties and potential for various uses. Chitinases play a crucial function in the breakdown of chitin, and their exceptionally effective production has garnered significant interest.

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Article Synopsis
  • - Bats are a major group of mammals with a unique immune system and play a role in spreading diseases (zoonoses) and fungi, affecting plants, animals, and humans.
  • - In Yunnan Province, China, researchers identified 75 fungal species from bats, with 36 being known pathogens and 39 non-pathogenic; the majority (77%) belonged to the Ascomycota group.
  • - Although there have been studies on fungi associated with bats, there's a significant gap in research regarding their role as carriers of fungi, emphasizing the need to understand their ecological impact.
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The nutritional quality improvement is among the most integral objective for any rice molecular breeding programs. The seed storage proteins (SSPs) have greater role to determine the nutritional quality of any cereal grains. Rice contains relatively balanced amino acid composition and the SSPs are fractioned into albumins (ALB), globulins (GLO), prolamins (PRO) and glutelins (GLU) according to differences in solubility.

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During a survey of the diversity of lignicolous fungi in Yunnan Province, China, we collected and identified five microfungi species from dead woody litters of trees in terrestrial habitats. Through both morphological comparisons and phylogenetic analyses of multi-gene sequences, we identified two taxa as new species and three collections as new host records within Pleosporales. is introduced as a sexual morph in Lophiostomataceae, is introduced as a hyphomycetous fungi in Phaeoseptaceae, and as a first report of sexual morph in .

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Revolutionizing Tomato Cultivation: CRISPR/Cas9 Mediated Biotic Stress Resistance.

Plants (Basel)

August 2024

Biotechnology School, Nile University, 26th of July Corridor, Sheikh Zayed City 12588, Giza, Egypt.

Tomato ( L.) is one of the most widely consumed and produced vegetable crops worldwide. It offers numerous health benefits due to its rich content of many therapeutic elements such as vitamins, carotenoids, and phenolic compounds.

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Breeding high yielding water-deficit tolerant rice is considered a primary goal for achieving the objectives of the sustainable development goals, 2030. However, evaluating the performance of the pre-breeding-promising parental-lines for water deficit tolerance prior to their incorporation in the breeding program is crucial for the success of the breeding programs. The aim of the current investigation is to assess the performance of a set of pre-breeding lines compared with their parents.

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Association between CYP1A2 gene variants -163 C/A (rs762551) and -3860 G/A (rs2069514) and bladder cancer susceptibility.

BMC Cancer

July 2024

Department of Urology, Minimally Invasive Surgery Center, Guangdong Key Laboratory of Urology, Guangzhou Urology Research Institute, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Bladder cancer (BLCA) poses a significant global health challenge due to its high incidence, poor prognosis, and limited treatment options.

Aims And Objectives: This study aims to investigate the association between two specific polymorphisms, CYP1A2-163 C/A and CYP1A2-3860G/A, within the Cytochrome P450 1A2 (CYP1A2) gene and susceptibility to BLCA.

Methods: The study employed a case-control design, genotyping 340 individuals using Polymerase Chain Reaction-High-Resolution Melting Curve (PCR-HRM).

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Three novel woody litter inhabiting fungi in Didymosphaeriaceae, Phaeoseptaceae and Synnemasporellaceae from Zhujiangyuan Nature Reserve, Yunnan Province, P.R. China.

MycoKeys

June 2024

Center for Yunnan Plateau Biological Resources Protection and Utilization, College of Biological Resource and Food Engineering, Qujing Normal University, Qujing, Yunnan Province 655011, China.

Zhujiangyuan Nature Reserve, located in Qujing City, Yunnan Province, China, is reported with high fauna and floral diversity, while the fungal diversity of the region is poorly documented. During the summer season in 2023, decaying wood-inhabiting microfungi were collected from different microhabitats. The novel species were identified based on morphological characteristics and phylogenetic analyses (based on combined datasets of ITS, LSU, SSU, 1-α, and 2 regions).

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In this work, pure and S-N/WO3 (1%-7%) nanoparticles (NPs) have been developed for the degradation of MB dye. Optical properties, vibrational analysis, morphology, structural analysis, and photocatalytic activity of the samples have been evaluated using a variety of characterization techniques, including UV-vis, PL, FTIR, SEM, and x-ray diffraction (XRD). The XRD patterns showed that the stability of the orthorhombic phase of WO3 was affected by the concentrations of S and N.

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The prevalence of consanguineous marriages (CMs) varies worldwide from one country to another. However, the Middle East stands out as a region with a notably high rate of CMs. CM is particularly widespread in Saudi Arabia, where the prevalence of autosomal recessive genetic diseases has increased.

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From port to planet: Assessing NO pollution and climate change effects with Sentinel-5p satellite imagery in maritime zones.

Environ Res

September 2024

Faculty of Sciences, Department of Botany, PMAS Arid Agriculture University, Rawalpindi, Punjab, 46300, Pakistan; Sustainable Process Integration Laboratory, SPIL, NETME Centre, Faculty of Mechanical Engineering, Brno University of Technology, VUT Brno, Technická 2896/2, Brno, 616 00, Czech Republic. Electronic address:

The growing effects of climate change on Malaysia's coastal ecology heighten worries about air pollution, specifically caused by urbanization and industrial activity in the maritime sector. Trucks and vessels are particularly noteworthy for their substantial contribution to gas emissions, including nitrogen dioxide (NO), which is the primary gas released in port areas. The application of advanced analysis techniques was spurred by the air pollution resulting from the combustion of fossil fuels such as fuel oil, natural gas and gasoline in vessels.

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Background: In November 2019, the world faced a pandemic called SARS-CoV-2, which became a major threat to humans and continues to be. To overcome this, many plants were explored to find a cure.

Methods: Therefore, this research was planned to screen out the active constituents from Artemisia annua that can work against the viral main protease Mpro as this non-structural protein is responsible for the cleavage of replicating enzymes of the virus.

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Multivariate pollution degree indices were utilized to evaluate the environmental condition of the Uppanar and Vellar estuaries. The Trophic Index (TRIX) indicates a state of "moderate eutrophication" with a value of 4.92, while the Trophic State Index (TSI) ranged from 40.

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Article Synopsis
  • * Major compounds identified in the EO included α-pinene and -cadinol, but the oil showed limited antioxidant activity, failing to neutralize certain free radicals effectively.
  • * The EO demonstrated strong leishmanicidal effects against promastigote and amastigote forms, with the components showing better binding to the enzyme CYP51 compared to the conventional drug fluconazole, suggesting it could be a promising alternative treatment for leishmaniasis.
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Physio-Biochemical, Anatomical, and Molecular Analysis of Resistant and Susceptible Wheat Cultivars Infected with TTKSK, TTKST, and TTTSK Novel Races.

Plants (Basel)

April 2024

EPCRS Excellence Center, Plant Pathology and Biotechnology Laboratory, Agricultural Botany Department, Faculty of Agriculture, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt.

Stem rust, caused by f.sp. , is one of the most dangerous rust diseases on wheat.

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Systemic Immune-Inflammation Index in Relation to Diabetes Markers in Saudi Adults: A Retrospective Study.

Medicina (Kaunas)

March 2024

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11362, Saudi Arabia.

: Low-grade inflammation is associated with metabolic disturbances like diabetes. The systemic immune-inflammation index (SII) has been proposed as a predictive tool to identify individuals at a greater risk of diabetes. This study aims to examine the association between SII and diabetes markers.

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Artificial intelligence in Immuno-genetics.

Bioinformation

January 2024

Department of Clinical Laboratory Sciences, College of Applied Medical Scienecs, King Saud University, Riyadh - 11433, Saudi Arabia.

Rapid advancements in the field of artificial intelligence (AI) have opened up unprecedented opportunities to revolutionize various scientific domains, including immunology and genetics. Therefore, it is of interest to explore the emerging applications of AI in immunology and genetics, with the objective of enhancing our understanding of the dynamic intricacies of the immune system, disease etiology, and genetic variations. Hence, the use of AI methodologies in immunological and genetic datasets, thereby facilitating the development of innovative approaches in the realms of diagnosis, treatment, and personalized medicine is reviewed.

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