8 results match your criteria: "Center of Bio-Medical Research[Affiliation]"
Chem Soc Rev
June 2022
Center of Bio-Medical Research, Division of Molecular Synthesis & Drug Discovery, SGPGIMS Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India.
J Am Chem Soc
April 2021
Center of Bio-Medical Research, Division of Molecular Synthesis & Drug Discovery, SGPGIMS Campus, Raebareli Road, Lucknow, 226014 Uttar Pradesh, India.
J Am Chem Soc
September 2020
Center of Bio-Medical Research, Division of Molecular Synthesis & Drug Discovery, SGPGIMS Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India.
A concept for intramolecular denitrogenative C(sp)-H amination of 1,2,3,4-tetrazoles bearing unactivated primary, secondary, and tertiary C-H bonds is discovered. This catalytic amination follows an unprecedented metalloradical activation mechanism. The utility of the method is showcased with the short synthesis of a bioactive molecule.
View Article and Find Full Text PDFOrg Lett
August 2019
Center of Bio-Medical Research, Division of Molecular Synthesis & Drug Discovery , SGPGIMS Campus, Raebareli Road , Lucknow 226014 , Uttar Pradesh , India.
A double-fold ortho and remote C-H borylation of BINOL is described. The proposed mechanisms involved electrostatically and sterically directed ortho and remote C-H activation processes, respectively. While Beg (eg = ethylene glycolate) directs the C-H activation at ortho positions, a combination of HBpin and Bpin activates remote C-H bonds.
View Article and Find Full Text PDFJ Am Chem Soc
July 2018
Center of Bio-Medical Research, Division of Molecular Synthesis & Drug Discovery , SGPGIMS Campus , Raebareli Road , Lucknow 226014 , Uttar Pradesh , India.
An efficient strategy for the intramolecular denitrogenative transannulation/C(sp)-H amination of 1,2,3,4-tetrazoles bearing C8-substituted arenes, heteroarenes, and alkenes is described. The process involves the generation of the metal-nitrene intermediate from tetrazole by the combination of [Cp*IrCl] and AgSbF. It has been shown that the reaction proceeds via an unprecedented electrocyclization process.
View Article and Find Full Text PDFJ Am Chem Soc
June 2017
Center of Bio-Medical Research, Division of Molecular Synthesis & Drug Discovery, SGPGIMS Campus , Raebareli Road, Lucknow 226014, Uttar Pradesh, India.
An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.
View Article and Find Full Text PDFJ Am Chem Soc
June 2017
Department of Chemistry, Michigan State University, 578 South Shaw Lane, East Lansing, Michigan 48824-1322 United States.
A strategy for affecting ortho versus meta/para selectivity in Ir-catalyzed C-H borylations (CHBs) of phenols is described. From selectivity observations with ArylOBpin (pin = pinacolate), it is hypothesized that an electrostatic interaction between the partial negatively charged OBpin group and the partial positively charged bipyridine ligand of the catalyst favors ortho selectivity. Experimental and computational studies designed to test this hypothesis support it.
View Article and Find Full Text PDFJ Am Chem Soc
January 2016
Center of Bio-Medical Research, Division of Molecular Synthesis & Drug Discovery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh 226014, India.
The ligand-enabled development of ortho and meta C-H borylation of aromatic aldehydes is reported. It was envisaged that while ortho borylation could be achieved using tert-butylamine as the traceless protecting/directing group, meta borylation proceeds via an electrostatic interaction and a secondary interaction between the ligand of the catalyst and the substrate. These ligand-substrate electrostatic interactions and secondary B-N interactions provide an unprecedented controlling factor for meta-selective C-H activation/borylation.
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