5 results match your criteria: "Center of Atherosclerosis and Lipid Disorders[Affiliation]"
Why selective screening for asymptomatic carotid stenosis is currently appropriate: a special report.
Expert Rev Cardiovasc Ther
May 2024
Department of Surgery, Division of Vascular and Endovascular Surgery, Charleston Area Medical Center/West Virginia University Health Sciences Center, Charleston, WV, USA.
Introduction: Two of the main reasons recent guidelines do not recommend routine population-wide screening programs for asymptomatic carotid artery stenosis (AsxCS) is that screening could lead to an increase of carotid revascularization procedures and that such mass screening programs may not be cost-effective. Nevertheless, selective screening for AsxCS could have several benefits. This article presents the rationale for such a program.
View Article and Find Full Text PDFBenefits and drawbacks of statins and non-statin lipid lowering agents in carotid artery disease.
Prog Cardiovasc Dis
September 2022
Department of Clinical Biochemistry, Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London, UK.
Article Synopsis
- International guidelines recommend using statins, alone or with other medications, to lower LDL cholesterol in patients with asymptomatic or symptomatic carotid stenosis, as it significantly reduces risks of stroke and cardiovascular events.
- The overview evaluates the effectiveness of various lipid-lowering agents, emphasizing that statins and PCSK9 inhibitors offer substantial benefits like stabilizing carotid plaques and lowering stroke rates, while non-statin options like ezetimibe and fibrates also help but to a lesser extent.
- Despite potential side effects, the advantages of lowering LDL cholesterol for these patients outweigh the risks, leading to a recommendation for high-dose statin therapy for all individuals, regardless of their baseline LDL levels.
Autoimmune nature of influenza atherogenicity.
Ann N Y Acad Sci
June 2005
Center of Atherosclerosis and Lipid Disorders, Chair of Cardiology, Mechnicov's State Medical Academy, Saint Petersburg, Russia.
It has been observed during influenza epidemics and in a number of population and clinical trials that this prevalent viral infection was associated with increased death rates from cardiovascular diseases. The clinical and experimental data that may explain accelerated coronary atherosclerosis in influenza infection with implications involving autoimmune mechanisms are analyzed in this article. Both cellular and humoral autoimmune modes could be proposed to participate in the onset or progression of atheromatous lesions due to influenza infection.
View Article and Find Full Text PDFStatins and autoimmune diseases.
Autoimmun Rev
March 2005
Mechnicov's State Medical Academy, The Center of Atherosclerosis and Lipid Disorders, Tel-Hashomer, Israel.
Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.
View Article and Find Full Text PDFInfluenza, autoimmunity and atherogenesis.
Autoimmun Rev
February 2005
Mechnicov's State Medical Academy, The Center of Atherosclerosis and Lipid Disorders, Chair of Cardiology, 194291 pr. Kultury 4, CMSD-122, Saint Petersburg, Russia.
It has been observed during influenza epidemics and in a number of population and clinical trials that this prevalent viral infection was associated with increased death rates from cardiovascular diseases. The clinical and experimental data that may explain accelerated coronary atherosclerosis in influenza infection with implications involving autoimmune mechanisms are reviewed in this article. Both cellular and humoral autoimmune mode could be proposed to participate in the onset or progression of atheromatous lesions due to influenza infection.
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